Reactome: A Curated Pathway Database

dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate

Stable Identifier
R-HSA-71495
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

In this freely reversible cytosolic reaction, dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate react to form D-fructose 1,6-bisphosphate. The active form of aldolase, the enzyme that catalyzes the reaction, is a homotetramer. Three aldolase isozymes have been identified which differ in their patterns of expression in various adult tissues and during development but are otherwise functionally indistinguishable (Ali and Cox 1995; Dunbar and Fothergill-Gilmore 1988).

Literature References
Participants
Participant Of
hasEvent
This entity is regulated by:
Title Physical Entity Activity
fructose-bisphosphate aldolase activity of aldolase tetramer [cytosol] aldolase tetramer [cytosol] fructose-bisphosphate aldolase activity (0004332)
Orthologous Events