Aldolase tetramers convert GA3P and DHAP to F1,6PP

Stable Identifier
R-HSA-71495
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate => beta-D-fructose 1,6-bisphosphate
ReviewStatus
5/5
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In this freely reversible cytosolic reaction, DHAP (dihydroxyacetone phosphate) and GA3P (D-glyceraldehyde 3-phosphate) react to form F1,6PP (D-fructose 1,6-bisphosphate). The active form of aldolase, the enzyme that catalyzes the reaction, is a homotetramer. Three aldolase isozymes have been identified which differ in their patterns of expression in various adult tissues and during development but are otherwise functionally indistinguishable (Ali and Cox 1995; Dunbar and Fothergill-Gilmore 1988).
Literature References
PubMed ID Title Journal Year
7717389 Diverse mutations in the aldolase B gene that underlie the prevalence of hereditary fructose intolerance

Cox, TM, Ali, M

Am J Hum Genet 1995
3355497 The complete amino acid sequence of human skeletal-muscle fructose-bisphosphate aldolase

Dunbar, B, Fothergill-Gilmore, LA

Biochem J 1988
Participants
Participates
Catalyst Activity

fructose-bisphosphate aldolase activity of aldolase tetramer [cytosol]

Orthologous Events
Cross References
Rhea
Reviewed
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