dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate

Stable Identifier
R-HSA-71495
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

In this freely reversible cytosolic reaction, dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate react to form D-fructose 1,6-bisphosphate. The active form of aldolase, the enzyme that catalyzes the reaction, is a homotetramer. Three aldolase isozymes have been identified which differ in their patterns of expression in various adult tissues and during development but are otherwise functionally indistinguishable (Ali and Cox 1995; Dunbar and Fothergill-Gilmore 1988).

Literature References
PubMed ID Title Journal Year
3355497 The complete amino acid sequence of human skeletal-muscle fructose-bisphosphate aldolase

Dunbar, B, Fothergill-Gilmore, LA

Biochem J 1988
7717389 Diverse mutations in the aldolase B gene that underlie the prevalence of hereditary fructose intolerance

Ali, M, Cox, TM

Am J Hum Genet 1995
Participants
Participant Of
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Event Information
Catalyst Activity
Catalyst Activity
Title
fructose-bisphosphate aldolase activity of aldolase tetramer [cytosol]
Physical Entity
Activity
Orthologous Events
Reviewed