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p-S-GYS1 [cytosol]
Stable Identifier
R-HSA-71570
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
phospho-GYS1, phosphorylated glycogen synthase 1
Icon
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycogen metabolism (Homo sapiens)
Glycogen synthesis (Homo sapiens)
Autoglucosylation of GYG1 complexed with GYS1-b (Homo sapiens)
GYG1:GYS1-b tetramer [cytosol] (Homo sapiens)
p-S-GYS1 [cytosol] (Homo sapiens)
oligoGlc-GYG1:GYS1-b tetramer [cytosol] (Homo sapiens)
p-S-GYS1 [cytosol] (Homo sapiens)
GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Homo sapiens)
glycogen-GYG1:GYS1-b tetramer [cytosol] (Homo sapiens)
p-S-GYS1 [cytosol] (Homo sapiens)
polyGlc-GYG1:GYS1-b tetramer [cytosol] (Homo sapiens)
p-S-GYS1 [cytosol] (Homo sapiens)
Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Homo sapiens)
oligoGlc-GYG1:GYS1-b tetramer [cytosol] (Homo sapiens)
p-S-GYS1 [cytosol] (Homo sapiens)
p-S-GYS1 [cytosol] (Homo sapiens)
polyGlc-GYG1:GYS1-b tetramer [cytosol] (Homo sapiens)
p-S-GYS1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P13807 GYS1
Gene Names
GYS1, GYS
Chain
chain:1-737
Reference Genes
BioGPS Gene:2997 GYS1
COSMIC (genes):GYS1 GYS1
CTD Gene:2997 GYS1
dbSNP Gene:2997 GYS1
ENSEMBL:ENSG00000104812 GYS1
ENSEMBL_homo_sapiens_GENE:ENSG00000104812.15 GYS1
HGNC:4706 GYS1
KEGG Gene (Homo sapiens):2997 GYS1
Monarch:2997 GYS1
NCBI Gene:2997 GYS1
OMIM:138570 GYS1
UCSC:P13807 GYS1
Reference Transcript
RefSeq:NM_001161587.1 GYS1
RefSeq:NM_002103.4 GYS1
Other Identifiers
11719371_a_at
11751201_a_at
11753041_a_at
16874156
201673_PM_s_at
201673_s_at
2997
37299_at
3867539
3867540
3867541
3867542
3867543
3867545
3867547
3867549
3867550
3867551
3867552
3867556
3867557
3867558
3867559
3867560
3867562
3867565
3867567
3867568
3867569
8038261
A_23_P208698
GE57509
GO:0003824
GO:0004373
GO:0005515
GO:0005536
GO:0005737
GO:0005829
GO:0005975
GO:0005977
GO:0005978
GO:0006091
GO:0007507
GO:0008152
GO:0016020
GO:0016234
GO:0016740
GO:0016757
GO:0048856
GO:0061547
HMNXSV003035361
ILMN_1711289
J04501_at
PH_hs_0024385
TC19001703.hg
TC19002540.hg
g4504232_3p_a_at
Participates
as a component of
glycogen-GYG1:GYS1-b tetramer [cytosol] (Homo sapiens)
polyGlc-GYG1:GYS1-b tetramer [cytosol] (Homo sapiens)
oligoGlc-GYG1:GYS1-b tetramer [cytosol] (Homo sapiens)
GYG1:GYS1-b tetramer [cytosol] (Homo sapiens)
Other forms of this molecule
GYS1 [cytosol]
GYS1 R462* [cytosol]
Inferred To
phospho-gys1 [cytosol]
(Danio rerio)
phospho-p-S-GYS1 [cytosol]
(Bos taurus)
phospho-p-S-GYS1 [cytosol]
(Caenorhabditis elegans)
phospho-p-S-GYS1 [cytosol]
(Dictyostelium discoideum)
phospho-p-S-GYS1 [cytosol]
(Drosophila melanogaster)
phospho-p-S-GYS1 [cytosol]
(Gallus gallus)
phospho-p-S-GYS1 [cytosol]
(Mus musculus)
phospho-p-S-GYS1 [cytosol]
(Rattus norvegicus)
phospho-p-S-GYS1 [cytosol]
(Saccharomyces cerevisiae)
phospho-GYS1 [cytosol]
(Canis familiaris)
phospho-GYS1 [cytosol]
(Sus scrofa)
Modified Residues
Name
O-phospho-L-serine at unknown position
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_002094.2
,
NP_001155059.1
OpenTargets
ENSG00000104812
ZINC - Substances
GYS1_HUMAN
ZINC target
P13807
PRO
P13807
PDB
8CVY
,
7Q13
,
8CVX
,
7Q0B
,
7Q0S
,
8CVZ
,
7Q12
,
7ZBN
IntEnz
2.4.1.11
HPA
ENSG00000104812-GYS1
GeneCards
P13807
Ensembl
ENST00000323798
,
ENSP00000263276
,
ENSP00000317904
,
ENST00000263276
,
ENSG00000104812
Pharos - Targets
P13807
ZINC - Predictions - Purchasable
GYS1_HUMAN
Orphanet
17469
HMDB Protein
HMDBP01094
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62136 PPP1CA
1
PPP1CA [cytosol]
(R-HSA-163525)
0.807
6
UniProt:P49841 GSK3B
4
GSK3B del304-316 [cytosol]
(R-HSA-5339682)
GSK3B [nucleoplasm]
(R-HSA-2022823)
p-S9-GSK3B [cytosol]
(R-HSA-3149577)
GSK3B [cytosol]
(R-HSA-2997551)
0.73
4
UniProt:Q9UQK1 PPP1R3C
2
K48polyUb-PPP1R3C [cytosol]
(R-HSA-3781005)
PPP1R3C [cytosol]
(R-HSA-3777102)
0.669
3
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
5
UniProt:P31273 HOXC8
1
HOXC8 [nucleoplasm]
(R-HSA-3222311)
0.556
3
UniProt:O43474 KLF4
1
KLF4 [nucleoplasm]
(R-HSA-434463)
0.556
5
UniProt:Q04446 GBE1
3
GBE1 R515C [cytosol]
(R-HSA-3878775)
GBE1 F257L [cytosol]
(R-HSA-3878767)
GBE1 [cytosol]
(R-HSA-71576)
0.527
2
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