3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate

Stable Identifier
R-HSA-71654
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cytosolic phosphoglycerate mutase catalyzes the reversible isomerisation of 3- and 2-phosphoglycerate. The active form of the enzyme is a dimer. There are two isoforms of this enzyme, PGAM1 (isoform B, widely expressed in non-muscle tissue) and PGAM2 (isoform M, expressed in muscle) (Blouquit et al. 1988; Omenn and Cheung 1974; Repiso et al. 2005; Tsujino et al. 1993).

Literature References
PubMed ID Title Journal Year
15710582 Phosphoglycerate mutase BB isoenzyme deficiency in a patient with non-spherocytic anemia: familial and metabolic studies

Repiso, A, Baso, MJR, Corrons, J-LV, Carreras, J, Climent, F

Haematologica 2005
4827367 Phosphoglycerate mutase isozyme marker for tissue differentiation in man

Omenn, GS, Cheung, SC

Am J Hum Genet 1974
2846554 Sequence of the human erythrocyte phosphoglycerate mutase by microsequencer and mass spectrometry

Blouquit, Y, Calvin, MC, Rosa, R, Prome, D, Prome, JC, Pratbernou, F, Cohen-Solal, M, Rosa, J

J Biol Chem 1988
8447317 The molecular genetic basis of muscle phosphoglycerate mutase (PGAM) deficiency

Tsujino, S, Shanske, S, Sakoda, S, Fenichel, G, DiMauro, S

Am J Hum Genet 1993
Participants
Participant Of
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Event Information
Catalyst Activity
Catalyst Activity
Title
phosphoglycerate mutase activity of PGAM dimers [cytosol]
Physical Entity
Activity
Orthologous Events