Reactome | 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O

2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O

Stable Identifier

R-HSA-71676

Type

Reaction

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic glutathione peroxidase (GPX1) tetramer catalyzes the reaction of reduced glutathione and hydrogen peroxide to form reduced glutathione and water (Chu et al. 1993).

Literature References

PubMed ID	Title	Journal	Year
3457020	Glutathione peroxidase protein. Absence in selenium deficiency states and correlation with enzymatic activity Takahashi, K, Newburger, PE, Cohen, HJ	J. Clin. Invest.	1986
20070187	Irreversible inactivation of glutathione peroxidase 1 and reversible inactivation of peroxiredoxin II by H2O2 in red blood cells Cho, CS, Lee, S, Lee, GT, Woo, HA, Choi, EJ, Rhee, SG	Antioxid. Redox Signal.	2010
807573	Purification and properties of human erythrocyte glutathione peroxidase Awasthi, YC, Beutler, E, Srivastava, SK	J. Biol. Chem.	1975
8428933	Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI Chu, FF, Doroshow, JH, Esworthy, RS	J Biol Chem	1993