Reactome | GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O

GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O

Stable Identifier

R-HSA-71676

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O

ReviewStatus

5/5

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GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O

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Cytosolic glutathione peroxidase (GPX1) tetramer catalyzes the reaction of reduced glutathione and hydrogen peroxide to form reduced glutathione and water (Chu et al. 1993).

Literature References

PubMed ID	Title	Journal	Year
20070187	Irreversible inactivation of glutathione peroxidase 1 and reversible inactivation of peroxiredoxin II by H2O2 in red blood cells Cho, CS, Lee, S, Lee, GT, Woo, HA, Choi, EJ, Rhee, SG	Antioxid. Redox Signal.	2010
3457020	Glutathione peroxidase protein. Absence in selenium deficiency states and correlation with enzymatic activity Takahashi, K, Newburger, PE, Cohen, HJ	J. Clin. Invest.	1986
807573	Purification and properties of human erythrocyte glutathione peroxidase Awasthi, YC, Beutler, E, Srivastava, SK	J. Biol. Chem.	1975
8428933	Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI Chu, FF, Doroshow, JH, Esworthy, RS	J Biol Chem	1993