glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+

Stable Identifier
R-HSA-71682
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cytosolic glutathione reductase catalyzes the reaction of glutathione (oxidized) and NADPH + H+ to form two molecules of glutathione (reduced) and NADP+ (Scott et al. 1963, Loos et al. 1976). Deficiency of glutathione reductase can cause hemolytic anemia.

Literature References
PubMed ID Title Journal Year
14086726 PURIFICATION AND PROPERTIES OF GLUTATHIONE REDUCTASE OF HUMAN ERYTHROCYTES

SCOTT, EM, DUNCAN, IW, EKSTRAND, V

J. Biol. Chem. 1963
947404 Familial deficiency of glutathione reductase in human blood cells

Loos, H, Roos, D, Weening, R, Houwerzijl, J

Blood 1976
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
glutathione-disulfide reductase activity of GSR-2:FAD dimer [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed