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PPA1 [cytosol]
Stable Identifier
R-HSA-71725
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
pyrophosphatase (inorganic) 1, Inorganic pyrophosphatase , Pyrophosphate phospho-hydrolase
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Pyrophosphate hydrolysis (Homo sapiens)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Homo sapiens)
PPA1 dimer [cytosol] (Homo sapiens)
PPA1 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
tRNA Aminoacylation (Homo sapiens)
Cytosolic tRNA aminoacylation (Homo sapiens)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Homo sapiens)
PPA1 dimer [cytosol] (Homo sapiens)
PPA1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15181 PPA1
Gene Names
PPA1, IOPPP, PP
Chain
initiator methionine:, chain:2-289
Reference Genes
BioGPS Gene:5464 PPA1
COSMIC (genes):PPA1 PPA1
CTD Gene:5464 PPA1
dbSNP Gene:5464 PPA1
ENSEMBL:ENSG00000180817 PPA1
HGNC:9226 PPA1
KEGG:hsa:5464 PPA1
Monarch:5464 PPA1
NCBI Gene:5464 PPA1
OMIM:179030 PPA1
UCSC:Q15181 PPA1
Reference Transcript
RefSeq:NM_021129.3 PPA1
Other Identifiers
11715684_a_at
16715133
217848_PM_s_at
217848_s_at
2841282
3293281
3293282
3293283
3293284
3293285
3293286
3293287
3293288
3293289
3293290
3293291
3293292
3293293
3293294
3293295
3293296
3293297
3293298
3293304
3293305
3293306
3293307
5464
59718_at
64333_s_at
7934133
A_23_P161338
A_33_P3271241
GE80789
GO:0000287
GO:0003824
GO:0004427
GO:0005737
GO:0005829
GO:0006796
GO:0016462
GO:0016787
GO:0043226
GO:0046872
GO:0070062
HMNXSV003033189
ILMN_1805827
PH_hs_0029963
TC10001362.hg
TC10002694.hg
g11056043_3p_a_at
Participates
as a component of
PPA1 dimer [cytosol] (Homo sapiens)
Inferred To
Homologues of PPA1 [cytosol]
(Plasmodium falciparum)
PPA1 [cytosol]
(Bos taurus)
PPA1 [cytosol]
(Caenorhabditis elegans)
PPA1 [cytosol]
(Canis familiaris)
PPA1 [cytosol]
(Dictyostelium discoideum)
PPA1 [cytosol]
(Drosophila melanogaster)
PPA1 [cytosol]
(Gallus gallus)
PPA1 [cytosol]
(Mus musculus)
PPA1 [cytosol]
(Plasmodium falciparum)
PPA1 [cytosol]
(Saccharomyces cerevisiae)
PPA1 [cytosol]
(Schizosaccharomyces pombe)
PPA1 [cytosol]
(Sus scrofa)
Ppa1 [cytosol]
(Rattus norvegicus)
ppa2 [cytosol]
(Xenopus tropicalis)
ppa1b [cytosol]
(Danio rerio)
Cross References
ENSEMBL
ENST00000373232
,
ENSP00000362329
OpenTargets
ENSG00000180817
HPA
ENSG00000180817-PPA1
PRO
Q15181
Pharos - Targets
Q15181
GlyGen
Q15181
HMDB Protein
HMDBP01071
PDB
7CMO
,
6C45
,
8J7Q
,
7BTN
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.615
11
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