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PFKFB2 [cytosol]
Stable Identifier
R-HSA-71790
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2, 6PF-2-K/Fru- 2,6-P2ASE heart-type isozyme, PFK-2/FBPase-2, 6- phosphofructo-2-kinase , Fructose-2,6-bisphosphatase
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glucose metabolism (Homo sapiens)
Glycolysis (Homo sapiens)
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Homo sapiens)
D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Homo sapiens)
PFKFB dimers [cytosol] (Homo sapiens)
PFKFB2 dimer [cytosol] (Homo sapiens)
PFKFB2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O60825 PFKFB2
Gene Names
PFKFB2
Chain
initiator methionine:, chain:2-505
Reference Genes
BioGPS Gene:5208 PFKFB2
COSMIC (genes):PFKFB2 PFKFB2
CTD Gene:5208 PFKFB2
dbSNP Gene:5208 PFKFB2
ENSEMBL:ENSG00000123836 PFKFB2
HGNC:8873 PFKFB2
KEGG:hsa:5208 PFKFB2
Monarch:5208 PFKFB2
NCBI Gene:5208 PFKFB2
OMIM:171835 PFKFB2
UCSC:O60825 PFKFB2
Reference Transcript
RefSeq:NM_006212.2 PFKFB2
RefSeq:NM_001018053.1 PFKFB2
Other Identifiers
11729378_a_at
11739947_a_at
11739948_at
11739949_at
11753069_a_at
11756171_a_at
16676693
207931_PM_s_at
207931_s_at
209992_PM_at
209992_at
226733_PM_at
226733_at
2377095
2377098
2377100
2377101
2377102
2377104
2377105
2377106
2377107
2377108
2377109
2377110
2377111
2377112
2377113
2377114
2377115
2377116
2377118
2377119
2377120
2377121
2377122
2377123
2377124
2377125
2377126
2377127
2377128
2377129
2377130
2377131
2377132
2377133
2377134
2377135
2377136
2377138
238450_PM_at
34107_at
34108_g_at
42964_at
5208
59051_at
70520_at
7909285
85152_at
A_14_P105616
A_14_P127529
A_23_P201508
A_24_P413669
A_33_P3300635
GE81612
GE88341
GO:0000166
GO:0003824
GO:0003873
GO:0004331
GO:0005515
GO:0005524
GO:0005654
GO:0005829
GO:0005975
GO:0006000
GO:0006003
GO:0006007
GO:0006089
GO:0006090
GO:0006091
GO:0006096
GO:0009749
GO:0016301
GO:0016740
GO:0016787
GO:0019900
GO:0019901
GO:0032024
GO:0046835
GO:0055086
GO:1901135
HMNXSV003040406
HMNXSV003057034
Hs.183235.0.A1_3p_at
Hs.184389.0.A1_3p_at
ILMN_1723436
ILMN_1796560
ILMN_2385298
PH_hs_0023455
TC01001731.hg
g11933148_3p_at
g5453877_3p_a_at
Participates
as a component of
PFKFB2 dimer [cytosol] (Homo sapiens)
Inferred To
Homologues of PFKFB2 [cytosol]
(Caenorhabditis elegans)
Homologues of PFKFB2 [cytosol]
(Dictyostelium discoideum)
Homologues of PFKFB2 [cytosol]
(Saccharomyces cerevisiae)
Homologues of PFKFB2 [cytosol]
(Schizosaccharomyces pombe)
PFKFB2 [cytosol]
(Bos taurus)
PFKFB2 [cytosol]
(Caenorhabditis elegans)
PFKFB2 [cytosol]
(Canis familiaris)
PFKFB2 [cytosol]
(Danio rerio)
PFKFB2 [cytosol]
(Dictyostelium discoideum)
PFKFB2 [cytosol]
(Drosophila melanogaster)
PFKFB2 [cytosol]
(Gallus gallus)
PFKFB2 [cytosol]
(Mus musculus)
PFKFB2 [cytosol]
(Rattus norvegicus)
PFKFB2 [cytosol]
(Saccharomyces cerevisiae)
PFKFB2 [cytosol]
(Schizosaccharomyces pombe)
PFKFB2 [cytosol]
(Sus scrofa)
PFKFB2 [cytosol]
(Xenopus tropicalis)
Cross References
ENSEMBL
ENST00000367079
,
ENST00000367080
,
ENSP00000356046
,
ENSP00000356047
OpenTargets
ENSG00000123836
IntEnz
3.1.3.46
HPA
ENSG00000123836-PFKFB2
ZINC target
O60825
PRO
O60825
Pharos - Targets
O60825
GlyGen
O60825
HMDB Protein
HMDBP00804
PDB
5HTK
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.802
6
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.725
5
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.527
3
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