1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ADP

Stable Identifier
R-HSA-71850
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
1,3-Bisphosphoglycerate and ADP react to form 3-phosphoglycerate and ATP
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic phosphoglycerate kinase (PGK) catalyzes the reaction of ADP and 1,3-bisphosphoglycerate (1,3BPG) to form D glyceraldehyde 3-phosphate (3PG) and ATP. The active form of the enzyme is a monomer and requires Mg++ (Yoshida and Watanabe 1972; Huang et al. 1980a,b). This is the first substrate level phosphorylation reaction in glycolysis. Two PGK isoforms are known: PGK1 is widely expressed in the body while PGK2 (Chen et al. 1976; McCarrey & Thomas 1987) appears to be confined to sperm cells.

Participants
Participant Of
hasEvent
Event Information
Catalyst Activity
Catalyst Activity
Title
phosphoglycerate kinase activity of PGK complexes [cytosol]
Physical Entity
Activity
Orthologous Events
Reviewed