Reactome | PRPF6 [nucleoplasm]

PRPF6 [nucleoplasm]

Stable Identifier

R-HSA-71881

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

U5-102 kDa protein, PRPU_HUMAN, U5 snRNP-associated 102 kDa protein

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O94906 PRPF6

Gene Names

PRPF6, C20orf14

Chain

chain:1-941

Reference Genes

BioGPS Gene:24148 PRPF6

COSMIC (genes):PRPF6 PRPF6

CTD Gene:24148 PRPF6

dbSNP Gene:24148 PRPF6

ENSEMBL:ENSG00000101161 PRPF6

HGNC:15860 PRPF6

KEGG:hsa:24148 PRPF6

Monarch:24148 PRPF6

NCBI Gene:24148 PRPF6

OMIM:613979 PRPF6

UCSC:O94906 PRPF6

Reference Transcript

RefSeq:NM_012469.3 PRPF6

Other Identifiers

11744203_a_at

16916166

208879_PM_x_at

208879_x_at

208880_PM_s_at

208880_s_at

24148

34345_at

3893850

3893851

3893855

3893856

3893858

3893859

3893862

3893863

3893864

3893865

3893866

3893868

3893870

3893871

3893872

3893874

3893875

3893876

3893877

3893879

3893881

3893886

3893887

3893888

3893889

3893890

8064218

A_14_P126083

A_23_P154539

GE54203

GO:0000244

GO:0000245

GO:0000375

GO:0000398

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005681

GO:0005682

GO:0006355

GO:0006396

GO:0006397

GO:0006403

GO:0008380

GO:0016020

GO:0016071

GO:0016607

GO:0030674

GO:0042802

GO:0043021

GO:0043226

GO:0045944

GO:0046540

GO:0060090

GO:0065003

GO:0071005

GO:0071013

HMNXSV003030602

Hs.31334.0.S1_3p_a_at

ILMN_1659259

PH_hs_0002666

TC20000531.hg

g4164165_3p_a_at

Participates

as an output of

Formation of the Spliceosomal Bact complex (Homo sapiens)

as a component of

Inferred To

Prp6 [nucleoplasm] (Drosophila melanogaster)

Prpf6 [nucleoplasm] (Mus musculus)

Prpf6 [nucleoplasm] (Rattus norvegicus)

prp1 [nucleoplasm] (Schizosaccharomyces pombe)

PRPF6 [nucleoplasm] (Bos taurus)

PRPF6 [nucleoplasm] (Canis familiaris)

PRPF6 [nucleoplasm] (Gallus gallus)

PRPF6 [nucleoplasm] (Plasmodium falciparum)

PRPF6 [nucleoplasm] (Sus scrofa)

prp-6 [nucleoplasm] (Caenorhabditis elegans)

prpf6 [nucleoplasm] (Dictyostelium discoideum)

prpf6 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_036601.2

OpenTargets

ENSG00000101161

ENSEMBL

ENST00000266079, ENSP00000266079

HPA

ENSG00000101161-PRPF6

PRO

O94906

Pharos - Targets

O94906

GlyGen

O94906

Orphanet

PRPF6

PDB

8H6E, 6QW6, 8Q7W, 8QPK, 8Q7V, 8QPE, 8Q7Q, 8Q7X, 8QZS, 8Q7N, 8QXD, 8QPB, 8QOZ, 8QPA, 6AHD, 6QX9, 8QP8, 8QP9, 8Y6O, 5O9Z, 6AH0, 8H6K, 3JCR, 8Q91, 8R0B, 8H6J, 8RC0, 8R0A, 8H6L, 8QO9, 8R09, 8RM5, 8R08

Interactors (30)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95400 CD2BP2	1	CD2BP2 [nucleoplasm] (R-HSA-72054)	0.931	11
UniProt:Q15029 EFTUD2	1	EFTUD2 [nucleoplasm] (R-HSA-71883)	0.838	7
UniProt:Q6P2Q9 PRPF8	1	PRPF8 [nucleoplasm] (R-HSA-83810)	0.774	6
UniProt:Q8WWY3 PRPF31	1	PRPF31 [nucleoplasm] (R-HSA-6806772)	0.755	6
UniProt:Q96DI7 SNRNP40	1	SNRNP40 [nucleoplasm] (R-HSA-71877)	0.744	5
UniProt:P83876 TXNL4A	1	TXNL4A [nucleoplasm] (R-HSA-71875)	0.728	6
UniProt:O75643 SNRNP200	1	SNRNP200 [nucleoplasm] (R-HSA-71885)	0.706	6
UniProt:O43290 SART1	1	SART1 [nucleoplasm] (R-HSA-4615999)	0.681	6
UniProt:P14678 SNRPB	4	2xMe-SNRPB [cytosol] (R-HSA-192218) SNRPB [cytosol] (R-HSA-191798) Me2-R108,R112-SNRPB [nucleoplasm] (R-HSA-192213) SNRPB [nucleoplasm] (R-HSA-71896)	0.669	4
UniProt:O43395 PRPF3	1	PRPF3 [nucleoplasm] (R-HSA-6806806)	0.669	5
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.669	3
UniProt:P62306 SNRPF	2	SNRPF [cytosol] (R-HSA-191852) SNRPF [nucleoplasm] (R-HSA-71907)	0.643	4
UniProt:O43172 PRPF4	1	PRPF4 [nucleoplasm] (R-HSA-71890)	0.643	3
UniProt:Q15428 SF3A2	1	SF3A2 [nucleoplasm] (R-HSA-71964)	0.564	2
UniProt:Q15287 RNPS1	2	RNPS1 [cytosol] (R-HSA-159256) RNPS1 [nucleoplasm] (R-HSA-156778)	0.564	2
UniProt:Q96AT1 K1143			0.527	2
UniProt:Q13523 PRPF4B	1	PRPF4B [nucleoplasm] (R-HSA-9769525)	0.527	2
UniProt:P16383 GCFC2	1	GCFC2 [nucleoplasm] (R-HSA-8869311)	0.527	2
UniProt:Q9BUQ8 DDX23	1	DDX23 [nucleoplasm] (R-HSA-71879)	0.527	3
UniProt:P63162 SNRPN	1	Me2-R108,R112-SNRPN [nucleoplasm] (R-HSA-8865931)	0.527	3
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:Q8NFN8 GP156			0.527	2
UniProt:P62304 SNRPE	2	SNRPE [cytosol] (R-HSA-191782) SNRPE [nucleoplasm] (R-HSA-71905)	0.527	4
UniProt:Q9BRS2 RIOK1	2	RIOK1 [nucleoplasm] (R-HSA-5226890) RIOK1 [cytosol] (R-HSA-6791525)	0.508	2
UniProt:O94906 PRPF6	1	PRPF6 [nucleoplasm] (R-HSA-71881)	0.508	2
UniProt:Q13123 IK	1	IK [nucleoplasm] (R-HSA-9770239)	0.508	2
UniProt:Q2TAY7 SMU1	1	SMU1 [nucleoplasm] (R-HSA-9770259)	0.508	2
UniProt:Q69YN4 VIR			0.499	2
UniProt:P35226 BMI1	3	BMI1 [nucleoplasm] (R-HSA-389121) p-S-BMI1 [nucleoplasm] (R-HSA-3229116) monoSUMO1-K88-BMI1 [nucleoplasm] (R-HSA-4551729)	0.499	8
UniProt:Q96T37 RBM15			0.483	2

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