Reactome | SNRPD2 [nucleoplasm]

SNRPD2 [nucleoplasm]

Stable Identifier

R-HSA-71901

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Sm protein D2, SMD2_HUMAN, Small nuclear ribonucleoprotein Sm D2, snRNP core protein D2, Sm-D2

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P62316 SNRPD2

Gene Names

SNRPD2, SNRPD1

Chain

initiator methionine:, chain:2-118

Reference Genes

BioGPS Gene:6633 SNRPD2

COSMIC (genes):SNRPD1 SNRPD2

COSMIC (genes):SNRPD2 SNRPD2

CTD Gene:6633 SNRPD2

dbSNP Gene:6633 SNRPD2

ENSEMBL:ENSG00000125743 SNRPD1

HGNC:11159 SNRPD2

KEGG:hsa:6633 SNRPD2

Monarch:6633 SNRPD2

NCBI Gene:6633 SNRPD2

OMIM:601061 SNRPD2

UCSC:P62316 SNRPD2

Reference Transcript

Other Identifiers

11757666_x_at

16873391

200826_PM_at

200826_at

35270_at

3865569

3865570

3865571

3865572

3865573

3865575

3865576

3865577

3865578

3865579

3865580

3865581

3865582

3865583

6633

8037642

A_24_P74160

GE58956

GO:0000245

GO:0000387

GO:0000398

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005681

GO:0005682

GO:0005684

GO:0005685

GO:0005686

GO:0005687

GO:0005689

GO:0005737

GO:0005829

GO:0006397

GO:0008380

GO:0016071

GO:0030532

GO:0034709

GO:0034715

GO:0034719

GO:0036261

GO:0043226

GO:0046540

GO:0065003

GO:0070062

GO:0071005

GO:0071007

GO:0071011

GO:0071013

GO:1903241

GO:1990904

HMNXSV003005449

ILMN_1771060

ILMN_2369785

PH_hs_0019804

PH_hs_0033284

TC19001628.hg

U15008_at

g7242206_3p_at

Participates

as a component of

Other forms of this molecule

SNRPD2 [cytosol]

Inferred To

SmD2 [nucleoplasm] (Drosophila melanogaster)

snrpd2 [nucleoplasm] (Danio rerio)

snrpd2 [nucleoplasm] (Dictyostelium discoideum)

snrpd2 [nucleoplasm] (Xenopus tropicalis)

SMD2 [nucleoplasm] (Saccharomyces cerevisiae)

snr-4 [nucleoplasm] (Caenorhabditis elegans)

SNRPD2 [nucleoplasm] (Bos taurus)

SNRPD2 [nucleoplasm] (Canis familiaris)

SNRPD2 [nucleoplasm] (Gallus gallus)

SNRPD2 [nucleoplasm] (Plasmodium falciparum)

SNRPD2 [nucleoplasm] (Sus scrofa)

Snrpd2 [nucleoplasm] (Mus musculus)

Snrpd2 [nucleoplasm] (Rattus norvegicus)

smd2 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_004588.1, NP_808210.2

OpenTargets

ENSG00000125743

ENSEMBL

ENSP00000375798, ENST00000588301, ENST00000342669, ENSP00000342374, ENSP00000465216, ENSP00000465952, ENSP00000466152, ENST00000587367, ENST00000588599, ENST00000391932

HPA

ENSG00000125743-SNRPD2

PRO

P62316

Pharos - Targets

P62316

GlyGen

P62316

PDB

5Z56, 8CH6, 5Z57, 7ABI, 7EVO, 3PGW, 6ID1, 7W5A, 6ID0, 1B34, 5XJQ, 8Q7Q, 8Q7X, 6Y53, 8QO9, 5O9Z, 8Y7E, 7B0Y, 6QW6, 3CW1, 5XJT, 5XJL, 8C6J, 6AH0, 7DVQ, 8RC0, 6AHD, 4WZJ, 7ABG, 8Y6O, 6Y5Q, 3JCR, 6QDV, 7A5P, 5XJC, 6FF7, 7W59, 7W5B, 8Q7V, 5XJR, 7VPX, 4V98, 6QX9, 8Q7W, 8HK1, 5XJU, 5Z58, 5XJS, 5MQF, 8Q91, 7QTT, 5YZG, 6ICZ, 4PJO, 4F7U

Interactors (38)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62306 SNRPF	2	SNRPF [cytosol] (R-HSA-191852) SNRPF [nucleoplasm] (R-HSA-71907)	0.885	15
UniProt:P54105 CLNS1A	1	CLNS1A [cytosol] (R-HSA-191796)	0.882	13
UniProt:P62312 LSM6	2	LSM6 [nucleoplasm] (R-HSA-6806794) LSM6 [cytosol] (R-HSA-429936)	0.804	6
UniProt:P14678 SNRPB	4	2xMe-SNRPB [cytosol] (R-HSA-192218) SNRPB [cytosol] (R-HSA-191798) Me2-R108,R112-SNRPB [nucleoplasm] (R-HSA-192213) SNRPB [nucleoplasm] (R-HSA-71896)	0.793	7
UniProt:Q9Y333 LSM2	2	LSM2 [nucleoplasm] (R-HSA-71894) LSM2 [cytosol] (R-HSA-429849)	0.748	4
UniProt:P62304 SNRPE	2	SNRPE [cytosol] (R-HSA-191782) SNRPE [nucleoplasm] (R-HSA-71905)	0.744	6
UniProt:Q16637 SMN1	2	SMN1 [nucleoplasm] (R-HSA-191892) SMN1 [cytosol] (R-HSA-191839)	0.725	5
UniProt:P08621 SNRNP70	1	SNRNP70 [nucleoplasm] (R-HSA-71913)	0.725	7
UniProt:O14893 GEMIN2	2	GEMIN2 [nucleoplasm] (R-HSA-191795) GEMIN2 [cytosol] (R-HSA-191835)	0.708	5
UniProt:P62314 SNRPD1	3	2xMe-SNRPD1 [cytosol] (R-HSA-192217) SNRPD1 [cytosol] (R-HSA-191890) 2xMe-SNRPD1 [nucleoplasm] (R-HSA-192215)	0.678	4
UniProt:Q9BUQ8 DDX23	1	DDX23 [nucleoplasm] (R-HSA-71879)	0.643	3
UniProt:P09661 SNRPA1	1	SNRPA1 [nucleoplasm] (R-HSA-71958)	0.643	5
UniProt:O43395 PRPF3	1	PRPF3 [nucleoplasm] (R-HSA-6806806)	0.643	4
UniProt:O95400 CD2BP2	1	CD2BP2 [nucleoplasm] (R-HSA-72054)	0.643	5
UniProt:Q8WWY3 PRPF31	1	PRPF31 [nucleoplasm] (R-HSA-6806772)	0.638	3
UniProt:Q9Y3F4 STRAP	1	STRAP [cytosol] (R-HSA-2127556)	0.59	2
UniProt:Q8WXD5 GEMIN6	2	GEMIN6 [nucleoplasm] (R-HSA-191799) GEMIN6 [cytosol] (R-HSA-191771)	0.59	2
UniProt:Q15428 SF3A2	1	SF3A2 [nucleoplasm] (R-HSA-71964)	0.564	2
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q9BW66 CINP			0.556	3
UniProt:Q5MJ10 SPXN2			0.556	3
UniProt:P54253 ATX1			0.556	3
UniProt:Q8NHQ1 CEP70	1	CEP70 [cytosol] (R-HSA-380257)	0.556	3
UniProt:P62318 SNRPD3	3	2xMe-SNRPD3 [cytosol] (R-HSA-191781) 2xMe-SNRPD3 [nucleoplasm] (R-HSA-192219) SNRPD3 [nucleoplasm] (R-HSA-71903)	0.527	2
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	4
UniProt:Q9UK45 LSM7	2	LSM7 [cytosol] (R-HSA-2028610) LSM7 [nucleoplasm] (R-HSA-6806802)	0.527	2
UniProt:P63162 SNRPN	1	Me2-R108,R112-SNRPN [nucleoplasm] (R-HSA-8865931)	0.527	3
UniProt:Q96DI7 SNRNP40	1	SNRNP40 [nucleoplasm] (R-HSA-71877)	0.527	3
UniProt:O43172 PRPF4	1	PRPF4 [nucleoplasm] (R-HSA-71890)	0.527	3
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.527	5
UniProt:P08579 SNRPB2	1	SNRPB2 [nucleoplasm] (R-HSA-71960)	0.527	5
UniProt:Q8TEQ6 GEMIN5	2	GEMIN5 [cytosol] (R-HSA-191833) GEMIN5 [nucleoplasm] (R-HSA-191765)	0.527	2
UniProt:P09234 SNRPC	1	SNRPC [nucleoplasm] (R-HSA-8865876)	0.527	4
UniProt:Q15020 SART3			0.527	2
UniProt:Q9Y4Z0 LSM4	2	LSM4 [cytosol] (R-HSA-429956) LSM4 [nucleoplasm] (R-HSA-6806804)	0.527	2
UniProt:P14678-2 SNRPB			0.499	2
UniProt:P09651 HNRNPA1	2	HNRNPA1 [nucleoplasm] (R-HSA-71927) HNRNPA1 [cytosol] (R-HSA-9727902)	0.483	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	7

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