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PTBP1 [nucleoplasm]
Stable Identifier
R-HSA-71923
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
hnRNP I, PTB_HUMAN, Polypyrimidine tract-binding protein 1, PTB, Heterogeneous nuclear ribonucleoprotein I, 57 kDa RNA-binding protein PPTB-1
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
Formation of pre-mRNPs (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
mRNA Splicing (Homo sapiens)
mRNA Splicing - Major Pathway (Homo sapiens)
Cleavage at the 3'-Splice Site and Exon Ligation (Homo sapiens)
intron-containing complex [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
pre-EJC:Spliceosomal C:pre-mRNP:CBC [nucleoplasm] (Homo sapiens)
hnRNP proteins [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
Formation of Exon Junction Complex (Homo sapiens)
Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
hnRNP proteins [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
pre-EJC:Spliceosomal C:pre-mRNP:CBC [nucleoplasm] (Homo sapiens)
hnRNP proteins [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
Formation of an intermediate Spliceosomal C (Bact) complex (Homo sapiens)
Spliceosomal B Complex [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
Spliceosomal Intermediate C (Bact) Complex [nucleoplasm] (Homo sapiens)
hnRNP proteins [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal A Complex (Homo sapiens)
Spliceosomal A Complex [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
Spliceosomal E Complex [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal B Complex (Homo sapiens)
Spliceosomal A Complex [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
Spliceosomal B Complex [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal E complex (Homo sapiens)
Spliceosomal E Complex [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
Formation of the active Spliceosomal C (B*) complex (Homo sapiens)
Spliceosomal Active C (B*) Complex [nucleoplasm] (Homo sapiens)
hnRNP proteins [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
Spliceosomal Intermediate C (Bact) Complex [nucleoplasm] (Homo sapiens)
hnRNP proteins [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
Lariat Formation and 5'-Splice Site Cleavage (Homo sapiens)
Spliceosomal Active C (B*) Complex [nucleoplasm] (Homo sapiens)
hnRNP proteins [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
hnRNP proteins [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by FGFR (Homo sapiens)
Signaling by FGFR2 (Homo sapiens)
FGFR2 alternative splicing (Homo sapiens)
FGFR2b-specific alternative splicing produces FGFR2b transcript (Homo sapiens)
FGFR2 IIIc-specific splicing complex [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
FGFR2c-specific alternative splicing produces FGFR2c transcript (Homo sapiens)
FGFR2 IIIc-specific splicing complex [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Homo sapiens)
FGFR2 IIIc-specific splicing complex [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P26599 PTBP1
Gene Names
PTBP1, PTB
Chain
chain:1-531
Reference Genes
BioGPS Gene:5725 PTBP1
COSMIC (genes):PTBP1 PTBP1
CTD Gene:5725 PTBP1
dbSNP Gene:5725 PTBP1
ENSEMBL:ENSG00000011304 PTBP1
HGNC:9583 PTBP1
KEGG Gene (Homo sapiens):5725 PTBP1
Monarch:5725 PTBP1
NCBI Gene:5725 PTBP1
OMIM:600693 PTBP1
UCSC:P26599 PTBP1
Reference Transcript
RefSeq:NM_031991.3 PTBP1
RefSeq:NM_002819.4 PTBP1
RefSeq:NM_031990.3 PTBP1
Other Identifiers
0004780156
11742456_a_at
11742457_s_at
11742677_x_at
11742678_s_at
16856257
16856273
202189_x_at
211270_x_at
211271_x_at
212015_x_at
212016_3p_s_at
212016_s_at
216306_x_at
3815167
3815169
3815170
3815171
3815172
3815174
3815176
3815178
3815179
3815181
3815183
3815188
3815192
3815193
3815194
3815195
3815196
3815197
3815198
3815199
3815200
3815201
3815202
3815203
40593_at
5725
8024019
A_14_P138892
A_24_P14367
GE59935
GE87923
GO:0000381
GO:0000398
GO:0003674
GO:0003676
GO:0003723
GO:0003729
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005730
GO:0006397
GO:0006412
GO:0006417
GO:0006464
GO:0007165
GO:0008150
GO:0008187
GO:0008380
GO:0008543
GO:0009058
GO:0016020
GO:0016070
GO:0030154
GO:0033119
GO:0034641
GO:0035307
GO:0036002
GO:0043226
GO:0043484
GO:0044403
GO:0045595
GO:0048025
GO:0048856
GO:0051148
GO:0070062
GO:0070886
GO:0075522
Hs.172550.3.S1_3p_a_at
Hs.172550.3.S1_3p_x_at
Hs.172550.6.A1_3p_a_at
ILMN_1655154
ILMN_2333319
PH_hs_0010319
TC19000015.hg
TC19000016.hg
g13325139_3p_a_at
g4506242_3p_x_at
Participant Of
input
Formation of pre-mRNPs
PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA
hasComponent
capped, methylated pre-mRNP:CBC complex [nucleoplasm]
FGFR2 IIIc-specific splicing complex [nucleoplasm]
hnRNP proteins [nucleoplasm]
intron-containing complex [nucleoplasm]
Spliceosomal A Complex [nucleoplasm]
Spliceosomal B Complex [nucleoplasm]
Spliceosomal E Complex [nucleoplasm]
Inferred To
PTBP1 [nucleoplasm] (Canis familiaris)
PTBP1 [nucleoplasm] (Dictyostelium discoideum)
PTBP1 [nucleoplasm] (Gallus gallus)
PTBP1 [nucleoplasm] (Plasmodium falciparum)
PTBP1 [nucleoplasm] (Sus scrofa)
ptb-1 [nucleoplasm] (Caenorhabditis elegans)
grm7 [nucleoplasm] (Xenopus tropicalis)
Ptbp1 [nucleoplasm] (Mus musculus)
Ptbp1 [nucleoplasm] (Rattus norvegicus)
ptbp1a [nucleoplasm] (Danio rerio)
Ghost homologue of PTBP1 [nucleoplasm] (Bos taurus)
Ghost homologue of PTBP1 [nucleoplasm] (Drosophila melanogaster)
Cross References
RefSeq
NP_114367.1
,
NP_002810.1
,
NP_114368.1
OpenTargets
ENSG00000011304
GeneCards
P26599
HPA
ENSG00000011304-PTBP1
Ensembl
ENSG00000011304
,
ENST00000394601
,
ENSP00000014112
,
ENST00000349038
,
ENST00000356948
,
ENSP00000408096
,
ENSP00000349428
PRO
P26599
PDB
1QM9
,
2AD9
,
2ADB
,
1SJR
,
1SJQ
,
2EVZ
,
2ADC
,
3ZZZ
,
3ZZY
,
2N3O
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P09012 SNRPA
1
SNRPA [nucleoplasm]
(R-HSA-71915)
0.8
7
UniProt:P23246 SFPQ
3
p-Y-SFPQ [nucleoplasm]
(R-HSA-8849461)
SFPQ [nucleoplasm]
(R-HSA-3900138)
SFPQ [cytosol]
(R-HSA-9635505)
0.702
4
UniProt:P98175 RBM10
0.666
4
UniProt:Q7ZYE9 Q7ZYE9
0.639
4
UniProt:Q96PU8 QKI
2
QKI-RAF1 fusion [cytosol]
(R-HSA-6802466)
p-QKI-BRAF fusion [cytosol]
(R-HSA-6802546)
0.635
3
UniProt:P26599 PTBP1
1
PTBP1 [nucleoplasm]
(R-HSA-71923)
0.553
2
UniProt:Q9UBW7 ZMYM2
6
ZMYM2(1-1059)-FLT3(594-993) fusion [cytosol]
(R-HSA-9703310)
ZMYM2(1-1057)-FLT3(586-993) fusion [cytosol]
(R-HSA-9703311)
ZMYM2(1-1057)-p-5Y FLT3(586-993) fusion [cytosol]
(R-HSA-9703319)
ZMYM2(1-1059)-p-4Y FLT3(594-993) fusion [cytosol]
(R-HSA-9703309)
ZMYM2-FGFR1 fusion [cytosol]
(R-HSA-1604544)
ZMYM2-p-2Y-FGFR1 fusion [cytosol]
(R-HSA-1839016)
0.524
2
UniProt:Q15365 PCBP1
1
PCBP1 [nucleoplasm]
(R-HSA-71919)
0.508
2
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