Reactome | PTBP1 [nucleoplasm]

PTBP1 [nucleoplasm]

Stable Identifier

R-HSA-71923

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

hnRNP I, PTB_HUMAN, Polypyrimidine tract-binding protein 1, PTB, Heterogeneous nuclear ribonucleoprotein I, 57 kDa RNA-binding protein PPTB-1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P26599 PTBP1

Gene Names

PTBP1, PTB

Chain

chain:1-531

Reference Genes

BioGPS Gene:5725 PTBP1

COSMIC (genes):PTBP1 PTBP1

CTD Gene:5725 PTBP1

dbSNP Gene:5725 PTBP1

ENSEMBL:ENSG00000011304 PTBP1

HGNC:9583 PTBP1

KEGG Gene (Homo sapiens):5725 PTBP1

Monarch:5725 PTBP1

NCBI Gene:5725 PTBP1

OMIM:600693 PTBP1

UCSC:P26599 PTBP1

Reference Transcript

Other Identifiers

0004780156

11742456_a_at

11742457_s_at

11742677_x_at

11742678_s_at

16856257

16856273

202189_x_at

211270_x_at

211271_x_at

212015_x_at

212016_3p_s_at

212016_s_at

216306_x_at

3815167

3815169

3815170

3815171

3815172

3815174

3815176

3815178

3815179

3815181

3815183

3815188

3815192

3815193

3815194

3815195

3815196

3815197

3815198

3815199

3815200

3815201

3815202

3815203

40593_at

5725

8024019

A_14_P138892

A_24_P14367

GE59935

GE87923

GO:0000381

GO:0000398

GO:0003674

GO:0003676

GO:0003723

GO:0003729

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005730

GO:0006397

GO:0006412

GO:0006417

GO:0006464

GO:0007165

GO:0008150

GO:0008187

GO:0008380

GO:0008543

GO:0009058

GO:0016020

GO:0016070

GO:0030154

GO:0033119

GO:0034641

GO:0035307

GO:0036002

GO:0043226

GO:0043484

GO:0044403

GO:0045595

GO:0048025

GO:0048856

GO:0051148

GO:0070062

GO:0070886

GO:0075522

Hs.172550.3.S1_3p_a_at

Hs.172550.3.S1_3p_x_at

Hs.172550.6.A1_3p_a_at

ILMN_1655154

ILMN_2333319

PH_hs_0010319

TC19000015.hg

TC19000016.hg

g13325139_3p_a_at

g4506242_3p_x_at

Participant Of

input

hasComponent

Inferred To

PTBP1 [nucleoplasm] (Canis familiaris)

PTBP1 [nucleoplasm] (Dictyostelium discoideum)

PTBP1 [nucleoplasm] (Gallus gallus)

PTBP1 [nucleoplasm] (Plasmodium falciparum)

PTBP1 [nucleoplasm] (Sus scrofa)

ptb-1 [nucleoplasm] (Caenorhabditis elegans)

grm7 [nucleoplasm] (Xenopus tropicalis)

Ptbp1 [nucleoplasm] (Mus musculus)

Ptbp1 [nucleoplasm] (Rattus norvegicus)

ptbp1a [nucleoplasm] (Danio rerio)

Ghost homologue of PTBP1 [nucleoplasm] (Bos taurus)

Ghost homologue of PTBP1 [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_114367.1, NP_002810.1, NP_114368.1

OpenTargets

ENSG00000011304

GeneCards

P26599

HPA

ENSG00000011304-PTBP1

Ensembl

ENSG00000011304, ENST00000394601, ENSP00000014112, ENST00000349038, ENST00000356948, ENSP00000408096, ENSP00000349428

PRO

P26599

PDB

1QM9, 2AD9, 2ADB, 1SJR, 1SJQ, 2EVZ, 2ADC, 3ZZZ, 3ZZY, 2N3O

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P09012 SNRPA	1	SNRPA [nucleoplasm] (R-HSA-71915)	0.8	7
UniProt:P23246 SFPQ	3	p-Y-SFPQ [nucleoplasm] (R-HSA-8849461) SFPQ [nucleoplasm] (R-HSA-3900138) SFPQ [cytosol] (R-HSA-9635505)	0.702	4
UniProt:P98175 RBM10			0.666	4
UniProt:Q7ZYE9 Q7ZYE9			0.639	4
UniProt:Q96PU8 QKI	2	QKI-RAF1 fusion [cytosol] (R-HSA-6802466) p-QKI-BRAF fusion [cytosol] (R-HSA-6802546)	0.635	3
UniProt:P26599 PTBP1	1	PTBP1 [nucleoplasm] (R-HSA-71923)	0.553	2
UniProt:Q9UBW7 ZMYM2	6	ZMYM2(1-1059)-FLT3(594-993) fusion [cytosol] (R-HSA-9703310) ZMYM2(1-1057)-FLT3(586-993) fusion [cytosol] (R-HSA-9703311) ZMYM2(1-1057)-p-5Y FLT3(586-993) fusion [cytosol] (R-HSA-9703319) ZMYM2(1-1059)-p-4Y FLT3(594-993) fusion [cytosol] (R-HSA-9703309) ZMYM2-FGFR1 fusion [cytosol] (R-HSA-1604544) ZMYM2-p-2Y-FGFR1 fusion [cytosol] (R-HSA-1839016)	0.524	2
UniProt:Q15365 PCBP1	1	PCBP1 [nucleoplasm] (R-HSA-71919)	0.508	2