Reactome | HNRNPA1 [nucleoplasm]

HNRNPA1 [nucleoplasm]

Stable Identifier

R-HSA-71927

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

hnRNP A1, ROA1_HUMAN, Heterogeneous nuclear ribonucleoprotein A1, Helix-destabilizing protein, Single-strand binding protein, hnRNP core protein A1

Locations in the PathwayBrowser for interactor UniProt:O95758 PTBP3

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External Reference Information

External Reference

UniProt:P09651 HNRNPA1

Gene Names

HNRNPA1, HNRPA1

Chain

chain:1-372, initiator methionine:, chain:2-372

Reference Genes

BioGPS Gene:3178 HNRNPA1

COSMIC (genes):HNRNPA1 HNRNPA1

CTD Gene:3178 HNRNPA1

dbSNP Gene:3178 HNRNPA1

ENSEMBL:ENSG00000135486 HNRNPA1

HGNC:5031 HNRNPA1

KEGG:hsa:3178 HNRNPA1

Monarch:3178 HNRNPA1

NCBI Gene:3178 HNRNPA1

OMIM:164017 HNRNPA1

UCSC:P09651 HNRNPA1

Reference Transcript

Participates

as a component of

as an input of

PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Homo sapiens)

as a member of

shuttling HNRNPs [nucleoplasm] (Homo sapiens)

Other forms of this molecule

HNRNPA1 [cytosol]

Inferred To

hnrnpa1b [nucleoplasm] (Danio rerio)

hrp-1 [nucleoplasm] (Caenorhabditis elegans)

hnrnpa1 [nucleoplasm] (Xenopus tropicalis)

Hnrnpa1 [nucleoplasm] (Mus musculus)

Hnrnpa1 [nucleoplasm] (Rattus norvegicus)

Homologues of HNRNPA1 [nucleoplasm] (Caenorhabditis elegans)

HNRNPA1 [nucleoplasm] (Bos taurus)

HNRNPA1 [nucleoplasm] (Caenorhabditis elegans)

HNRNPA1 [nucleoplasm] (Canis familiaris)

HNRNPA1 [nucleoplasm] (Gallus gallus)

HNRNPA1 [nucleoplasm] (Sus scrofa)

sqd-1 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_002127.1, XP_005268883.1, NP_112420.1

OpenTargets

ENSG00000135486

ENSEMBL

ENST00000546500, ENSG00000135486, ENSP00000341826, ENSP00000503610, ENSP00000448617, ENST00000547566, ENST00000677210, ENST00000547276, ENST00000340913, ENSP00000446486, ENSP00000449913, ENSP00000447260, ENST00000550482

ZINC - Substances

ROA1_HUMAN

ZINC - Biogenic

ROA1_HUMAN

ZINC target

P09651

PRO

P09651

GlyGen

P09651

PDB

4YOE, 9F54, 7ZJ2, 6J60, 9F51, 9F1S, 8IK7, 9F5G, 9F4G, 2UP1, 8IKP, 6DCL, 5ZGD, 2LYV, 1PGZ, 9F4L, 9F4N, 9F55, 6BXX, 2H4M, 1U1L, 9GEA, 1UP1, 9F52, 7BX7, 9GPJ, 1U1R, 9F53, 9F4Z, 9F4X, 9F50, 9F4P, 9F7F, 9F4U, 9F4V, 5MPG, 9F4S, 5MPL, 1U1M, 5ZGL, 9F4T, 9F4M, 9F4K, 9F5F, 9F5D, 9HQJ, 9F5E, 8IKS, 9F4H, 9F4J, 9F4D, 1L3K, 1U1K, 8RZV, 1PO6, 9F5K, 9F4W, 9F4Y, 9HQL, 9F4R, 9F4O, 8IKB, 9F5C, 1HA1, 1U1O, 1U1P, 1U1N, 1U1Q, 9F7H, 9F4Q

GeneCards

HNRNPA1

HPA

ENSG00000135486-HNRNPA1

Pharos - Targets

P09651

Orphanet

HNRNPA1

Interactors (78)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q07666 KHDRBS1	3	KHDRBS1 [nucleoplasm] (R-HSA-8848941) p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm] (R-HSA-8848970) p-Y435,Y440,Y443-KHDRBS1 [cytosol] (R-HSA-8848995)	0.875	10
UniProt:P07910 HNRNPC	3	HNRNPC [nucleoplasm] (R-HSA-71933) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [cytosol] (R-HSA-9715136)	0.792	5
UniProt:Q8IUH3 RBM45			0.744	7
UniProt:Q9NZB2 F120A			0.706	4
UniProt:P31943 HNRNPH1	1	HNRNPH1 [nucleoplasm] (R-HSA-71941)	0.706	4
UniProt:P38159 RBMX	2	RBMX [cytosol] (R-HSA-9715135) RBMX [nucleoplasm] (R-HSA-71939)	0.706	4
UniProt:P35637 FUS	1	FUS [nucleoplasm] (R-HSA-72040)	0.671	5
UniProt:P22626 HNRNPA2B1	2	HNRNPA2B1 [nucleoplasm] (R-HSA-71929) HNRNPA2B1 [extracellular exosome] (R-HSA-8950304)	0.669	3
UniProt:P31942 HNRH3			0.659	3
UniProt:P38919 EIF4A3	2	EIF4A3 [cytosol] (R-HSA-927868) EIF4A3 [nucleoplasm] (R-HSA-8849149)	0.643	3
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.643	4
UniProt:O75319 DUS11			0.643	3
UniProt:Q96PK6 RBM14	1	RBM14 [nucleoplasm] (R-HSA-8938345)	0.615	3
UniProt:P23246 SFPQ	3	SFPQ [nucleoplasm] (R-HSA-3900138) p-Y-SFPQ [nucleoplasm] (R-HSA-8849461) SFPQ [cytosol] (R-HSA-9635505)	0.615	3
UniProt:P78332 RBM6			0.615	3
UniProt:P14866 HNRNPL	1	HNRNPL [nucleoplasm] (R-HSA-71947)	0.615	3
UniProt:P59595 N	9	N [cytosol] (R-COV-9683625) p-S177-N [cytosol] (R-COV-9683754) ADPr-p-S177-N [cytosol] (R-COV-9686058) SUMO1-K62-ADPr-p-S177-N [cytosol] (R-COV-9682916) SUMO1-K62-ADPr-p-S177-N [viral capsid] (R-COV-9685478) SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9683641) N [plasma membrane] (R-COV-9683611) SUMO1-K62-ADPr-p-S177-N [nucleolus] (R-COV-9683730) SUMO1-K62-ADPr-p-S177-N [plasma membrane] (R-COV-9686063)	0.602	3
UniProt:P27958-PRO_0000037577			0.599	4
UniProt:P11387 TOP1	2	TOP1 [nucleoplasm] (R-HSA-4641363) monoSUMO1-K117-TOP1 [nucleoplasm] (R-HSA-4641364)	0.597	4
UniProt:Q5BKZ1 ZN326			0.597	4
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.564	2
UniProt:P51991 HNRNPA3	1	HNRNPA3 [nucleoplasm] (R-HSA-71931)	0.564	2
UniProt:Q8NC51 SERB1			0.548	4
UniProt:P09651 HNRNPA1	2	HNRNPA1 [nucleoplasm] (R-HSA-71927) HNRNPA1 [cytosol] (R-HSA-9727902)	0.536	2
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.536	2
UniProt:Q9Y2Z4 YARS2	1	YARS2 [mitochondrial matrix] (R-HSA-379634)	0.527	2
UniProt:Q9NPE2 NGRN	1	NGRN [mitochondrial matrix] (R-HSA-9936265)	0.527	2
UniProt:Q9BTD8 RBM42	1	RBM42 [nucleoplasm] (R-HSA-9769526)	0.527	2
UniProt:Q9Y5S9 RBM8A	2	RBM8A [cytosol] (R-HSA-162462) RBM8A [nucleoplasm] (R-HSA-156659)	0.527	2
UniProt:O95900 TRUB2	1	TRUB2 [mitochondrial matrix] (R-HSA-9936283)	0.527	2
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.527	3
UniProt:Q08211 DHX9	3	DHX9 [cytosol] (R-HSA-847700) p-DHX9 [cytosol] (R-HSA-9836168) DHX9 [nucleoplasm] (R-HSA-53517)	0.527	2
UniProt:Q12906 ILF3	3	ILF3 [cytosol] (R-HSA-450564) p-T188,T315-ILF3 [cytosol] (R-HSA-9836381) ILF3 [nucleoplasm] (R-HSA-9760401)	0.527	2
UniProt:O75127 PTCD1			0.527	2
UniProt:P43243 MATR3			0.527	2
UniProt:Q9NYY8 FASTKD2	1	FASTKD2 [mitochondrial matrix] (R-HSA-9837146)	0.527	2
UniProt:O95363 FARS2	1	FARS2(1-?) [mitochondrial matrix] (R-HSA-379565)	0.527	2
UniProt:Q96E29 MTERF3	5	MTERF3 [mitochondrial matrix] (R-HSA-9936251) Ub-MTERFD1 [mitochondrial outer membrane] (R-HSA-9843333) K48polyUb-MTERFD1 [mitochondrial outer membrane] (R-HSA-5205630) K63polyUb-MTERFD1 [mitochondrial outer membrane] (R-HSA-9834044) p-S65-Ub:MTERFD1 [mitochondrial outer membrane] (R-HSA-9843337)	0.527	2
UniProt:Q8ND56 LS14A			0.527	2
UniProt:Q9UHD9 UBQLN2	1	UBQLN2 [cytosol] (R-HSA-8866007)	0.524	2
UniProt:Q8IZH2 XRN1	1	XRN1 [cytosol] (R-HSA-429835)	0.519	2
UniProt:Q32P51 RA1L2			0.499	2
UniProt:Q14141 SEPT6			0.499	3
UniProt:Q14151 SAFB2			0.483	2
UniProt:Q15233 NONO			0.483	3
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.483	2
UniProt:Q13151 HNRNPA0	1	HNRNPA0 [nucleoplasm] (R-HSA-71925)	0.483	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	10
UniProt:Q96I24 FUBP3			0.483	2
UniProt:Q7L2J0 MEPCE			0.483	2
UniProt:Q9H0D6 XRN2	2	XRN2 [nucleoplasm] (R-HSA-6791205) XRN2 [cytosol] (R-HSA-391297)	0.483	2
UniProt:Q6UN15 FIP1L1	9	FIP1L1 [nucleoplasm] (R-HSA-6805150) FIP1L1(1-339)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9672499) FIP1L1(1-272)-PDGFRA(567-1089) fusion [cytosol] (R-HSA-9672496) FIP1L1(1-391)insAQCP-PDGFRA(577-1089) fusion [cytosol] (R-HSA-9672502) FIP1L1(1-392)insDCY-PDGFRA(585-1089) fusion [cytosol] (R-HSA-9672506) p-11Y-FIP1L1(1-339)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673872) p-11Y-FIP1L1(1-392)insDCY-PDGFRA(585-1089) fusion [cytosol] (R-HSA-9673621) p-11Y-FIP1L1(1-391)insAQCP-PDGFRA(577-1089) fusion [cytosol] (R-HSA-9673879) p-11Y-FIP1L1(1-272)-PDGFRA(567-1069) fusion [cytosol] (R-HSA-9673867)	0.483	2
UniProt:O43823 AKAP8			0.483	2
UniProt:P47756 CAPZB	1	CAPZB [cytosol] (R-HSA-879409)	0.483	2
UniProt:Q8IX01 SUGP2			0.483	2
UniProt:Q9HCK8 CHD8	1	CHD8 [nucleoplasm] (R-HSA-3221598)	0.483	2
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.483	2
UniProt:Q86VM9 ZC3H18	1	ZC3H18 [nucleoplasm] (R-HSA-9930040)	0.483	2
UniProt:Q12905 ILF2	5	ILF2 [ficolin-1-rich granule lumen] (R-HSA-6801001) ILF2 [extracellular region] (R-HSA-6799684) ILF2 [specific granule lumen] (R-HSA-6799611) ILF2 [tertiary granule lumen] (R-HSA-6800995) ILF2 [cytosol] (R-HSA-9836392)	0.483	2
UniProt:P55265 ADAR	2	ADAR [nucleoplasm] (R-HSA-53939) ADAR1 [cytosol] (R-HSA-9835955)	0.483	2
UniProt:P62316 SNRPD2	2	SNRPD2 [cytosol] (R-HSA-191810) SNRPD2 [nucleoplasm] (R-HSA-71901)	0.483	2
UniProt:O95758 PTBP3			0.483	2
UniProt:Q96KR1 ZFR			0.483	2
UniProt:Q96SI9 STRBP			0.483	2
UniProt:P55795 HNRNPH2	1	HNRNPH2 [nucleoplasm] (R-HSA-71943)	0.483	2
UniProt:Q14498 RBM39	1	RBM39 [nucleoplasm] (R-HSA-9770254)	0.483	2
UniProt:Q16630 CPSF6	2	CPSF6(1-490)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1838987) CPSF6(1-490)-FGFR1(429-822) fusion [cytosol] (R-HSA-1614368)	0.483	2
UniProt:Q13285 NR5A1	3	NR5A1 [nucleoplasm] (R-HSA-452955) polySUMO2-K119,K194-NR5A1 [nucleoplasm] (R-HSA-4546383) monoSUMO1-K119,K194-NR5A1 [nucleoplasm] (R-HSA-4546382)	0.483	2
UniProt:Q14966 ZNF638	1	ZNF638 [nucleoplasm] (R-HSA-8939429)	0.483	2
UniProt:Q15717 ELAVL1	6	ELAVL1 [nucleoplasm] (R-HSA-450601) p-S158,S221-ELAVL1 [nucleoplasm] (R-HSA-450576) p-S221,S318-ELAVL1 [nucleoplasm] (R-HSA-450532) ELAVL1 [cytosol] (R-HSA-450582) p-S221,S318-ELAVL1 [cytosol] (R-HSA-450448) p-S158,S221-ELAVL1 [cytosol] (R-HSA-450376)	0.483	2
UniProt:Q15424 SAFB	3	SAFB [nucleoplasm] (R-HSA-4085379) polySUMO2,3-K231,K294-SAFB [nucleoplasm] (R-HSA-4085357) monoSUMO1-K231,K294-SAFB [nucleoplasm] (R-HSA-4085343)	0.483	2
UniProt:P17844 DDX5	4	DDX5 [nucleoplasm] (R-HSA-3900136) DDX5 [cytosol] (R-HSA-9682643) polySUMO2-K53-DDX5 [nucleoplasm] (R-HSA-3900186) monoSUMO1-K53-DDX5 [nucleoplasm] (R-HSA-3900041)	0.483	2
UniProt:Q9BXP5 SRRT	1	SRRT [nucleoplasm] (R-HSA-6814858)	0.483	2
UniProt:Q9UKV3 ACIN1	4	ACIN1 [cytosol] (R-HSA-212519) ACIN1(1094-1341) [cytosol] (R-HSA-212516) ACIN1(1-1093) [cytosol] (R-HSA-212520) ACIN1 [nucleoplasm] (R-HSA-9770238)	0.483	2
UniProt:Q9UKV8 AGO2	2	AGO2 [cytosol] (R-HSA-209723) AGO2 [nucleoplasm] (R-HSA-5578701)	0.483	2
IntAct:EBI-6857440 NS3			0.462	2
UniProt:O60477 BRNP1			0.462	2
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.462	2

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