Reactome | HNRNPH1 [nucleoplasm]

HNRNPH1 [nucleoplasm]

Stable Identifier

R-HSA-71941

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

hnRNP H, ROH1_HUMAN, Heterogeneous nuclear ribonucleoprotein H

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Homo sapiens)

- Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
  - Formation of pre-mRNPs (Homo sapiens)
    - Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
      - shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH1 [nucleoplasm] (Homo sapiens)
    - capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
      - Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH1 [nucleoplasm] (Homo sapiens)
  - mRNA Splicing (Homo sapiens)
    - mRNA Splicing - Major Pathway (Homo sapiens)
      - Formation of the Spliceosomal A complex (Homo sapiens)
        
        Spliceosomal A complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH1 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal E complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH1 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal B complex (Homo sapiens)
        
        Spliceosomal B complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH1 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH1 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal B* complex (Homo sapiens)
        
        Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH1 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH1 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal Bact complex (Homo sapiens)
        
        Spliceosomal B complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH1 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH1 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal C complex containing intron lariat (Homo sapiens)
        
        Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH1 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal C complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH1 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal C* complex (Homo sapiens)
        
        Spliceosomal C complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH1 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH1 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal E complex (Homo sapiens)
        
        Spliceosomal E complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH1 [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH1 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal P complex and exon ligation (Homo sapiens)
        
        Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH1 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal P complex [nucleoplasm] (Homo sapiens)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH1 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal Pre-B complex (Homo sapiens)
        
        Spliceosomal A complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH1 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH1 [nucleoplasm] (Homo sapiens)
      - Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)
        
        Spliceosomal P complex [nucleoplasm] (Homo sapiens)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH1 [nucleoplasm] (Homo sapiens)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P31943 HNRNPH1

Gene Names

HNRNPH1, HNRPH, HNRPH1

Chain

chain:1-449, initiator methionine:, chain:2-449

Reference Genes

BioGPS Gene:3187 HNRNPH1

COSMIC (genes):HNRNPH1 HNRNPH1

CTD Gene:3187 HNRNPH1

dbSNP Gene:3187 HNRNPH1

ENSEMBL:ENSG00000169045 HNRNPH1

HGNC:5041 HNRNPH1

KEGG:hsa:3187 HNRNPH1

Monarch:3187 HNRNPH1

NCBI Gene:3187 HNRNPH1

OMIM:601035 HNRNPH1

UCSC:P31943 HNRNPH1

Reference Transcript

Other Identifiers

11743099_a_at

17003682

201031_PM_s_at

201031_s_at

213470_3p_s_at

213470_PM_s_at

213470_s_at

213472_3p_at

213472_PM_at

213472_at

2379158

2844183

2844185

2857385

2857393

2890150

2890151

2890152

2890153

2890154

2890155

2890156

2890157

2890158

2890159

2890160

2890161

2890162

2890163

2890164

2890165

2890166

2890167

2890168

2890169

2890170

2890171

2890172

2890173

2890174

2890175

2890176

2890177

2890178

2890179

2890180

2890181

2890182

2890183

2890184

2890186

2890188

3187

3249757

41292_at

55231_at

79883_at

8116297

A_21_P0004082

A_21_P0004344

A_24_P320254

A_24_P337380

GE84820

GE885837

GO:0000398

GO:0003676

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005681

GO:0005829

GO:0006396

GO:0006397

GO:0008266

GO:0008380

GO:0016020

GO:0016071

GO:0042802

GO:0043226

GO:0043484

GO:0071013

GO:1990904

HMNXSV003016247

HMNXSV003039617

HMNXSV003049353

Hs.245710.2.S1_3p_a_at

Hs.245710.2.S1_3p_at

Hs.245710.2.S1_3p_x_at

Hs.245710.2.S2_3p_a_at

Hs.245710.2.S2_3p_at

Hs.245710.2.S2_3p_x_at

ILMN_2101920

ILMN_2101928

L22009_at

PH_hs_0023001

TC05002778.hg

g5031752_3p_at

p14053

p23128

p27607

Participates

as a component of

as a member of

shuttling HNRNPs [nucleoplasm] (Homo sapiens)

Inferred To

HNRNPH1 [nucleoplasm] (Bos taurus)

HNRNPH1 [nucleoplasm] (Canis familiaris)

HNRNPH1 [nucleoplasm] (Gallus gallus)

HNRNPH1 [nucleoplasm] (Sus scrofa)

Homologues of HNRNPH1 [nucleoplasm] (Caenorhabditis elegans)

Homologues of HNRNPH1 [nucleoplasm] (Danio rerio)

hnrnph1l [nucleoplasm] (Danio rerio)

glo [nucleoplasm] (Drosophila melanogaster)

Hnrnph1 [nucleoplasm] (Mus musculus)

Hnrnph1 [nucleoplasm] (Rattus norvegicus)

hrpf-2 [nucleoplasm] (Caenorhabditis elegans)

hnrnph1 [nucleoplasm] (Danio rerio)

hnrnph1 [nucleoplasm] (Xenopus tropicalis)

hrpf-1 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001244222.1, XP_016864905.1, XP_016864904.1, XP_016864906.1, NP_005511.1

OpenTargets

ENSG00000169045

ENSEMBL

ENST00000442819, ENSP00000518319, ENST00000710502, ENSP00000377082, ENSP00000518318, ENST00000710500, ENSP00000518317, ENSP00000425343, ENSP00000349168, ENSP00000397797, ENSP00000429661, ENSP00000518316, ENSP00000426518, ENST00000513225, ENST00000356731, ENST00000710515, ENST00000505811, ENST00000393432, ENST00000638505, ENSP00000518308, ENST00000710513, ENST00000710512, ENSP00000518309, ENST00000710511, ENST00000710510, ENST00000521116, ENSP00000421695, ENSP00000424087, ENSP00000492076, ENST00000515714, ENSP00000518321, ENST00000515158

HPA

ENSG00000169045-HNRNPH1

PRO

P31943

Pharos - Targets

P31943

GlyGen

P31943

Orphanet

HNRNPH1

PDB

7ZUG, 6DHS, 2LXU

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P09651 HNRNPA1	2	HNRNPA1 [nucleoplasm] (R-HSA-71927) HNRNPA1 [cytosol] (R-HSA-9727902)	0.706	4
UniProt:P52597 HNRNPF	2	HNRNPF [nucleoplasm] (R-HSA-71937) HNRNPF [plasma membrane] (R-HSA-8950714)	0.666	4
UniProt:P52272 HNRNPM	1	HNRNPM [nucleoplasm] (R-HSA-71949)	0.666	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	14
UniProt:O15160 POLR1C	2	POLR1C [cytosol] (R-HSA-1964454) POLR1C [nucleoplasm] (R-HSA-63498)	0.601	4
UniProt:Q9Y5V3 MAGED1	1	MAGED1 [cytosol] (R-HSA-196002)	0.556	3
UniProt:Q13227 GPS2	1	GPS2 [nucleoplasm] (R-HSA-351642)	0.556	3
UniProt:Q92841 DDX17	2	monoSUMO1-K50-DDX17 [nucleoplasm] (R-HSA-3900104) DDX17 [nucleoplasm] (R-HSA-3900090)	0.556	3
UniProt:Q8TDS5 OXER1	1	OXER1 [plasma membrane] (R-HSA-416425)	0.556	3
UniProt:P17844 DDX5	4	DDX5 [nucleoplasm] (R-HSA-3900136) DDX5 [cytosol] (R-HSA-9682643) polySUMO2-K53-DDX5 [nucleoplasm] (R-HSA-3900186) monoSUMO1-K53-DDX5 [nucleoplasm] (R-HSA-3900041)	0.547	2
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	5
UniProt:Q9NQ92 COPRS	1	COPRS [nucleoplasm] (R-HSA-5212681)	0.527	2
UniProt:O43464 HTRA2	1	HTRA2 [mitochondrial intermembrane space] (R-HSA-56655)	0.527	2
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.527	2
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.527	4