Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
HNRNPM [nucleoplasm]
Stable Identifier
R-HSA-71949
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
hnRNP M, ROM_HUMAN, Heterogeneous nuclear ribonucleoprotein M
Locations in the PathwayBrowser for interactor UniProt:P25791 LMO2
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by FGFR (Homo sapiens)
Signaling by FGFR2 (Homo sapiens)
FGFR2 alternative splicing (Homo sapiens)
ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression (Homo sapiens)
HNRNPM [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P52272 HNRNPM
Gene Names
HNRNPM, HNRPM, NAGR1
Chain
initiator methionine:, chain:2-730
Reference Genes
BioGPS Gene:4670 HNRNPM
COSMIC (genes):HNRNPM HNRNPM
CTD Gene:4670 HNRNPM
dbSNP Gene:4670 HNRNPM
ENSEMBL:ENSG00000099783 HNRNPM
HGNC:5046 HNRNPM
KEGG:hsa:4670 HNRNPM
Monarch:4670 HNRNPM
NCBI Gene:4670 HNRNPM
OMIM:160994 HNRNPM
UCSC:P52272 HNRNPM
Reference Transcript
RefSeq:NM_005968.4 HNRNPM
RefSeq:NM_031203.3 HNRNPM
Other Identifiers
11739175_a_at
1555843_PM_at
1555843_at
1555844_PM_s_at
1555844_s_at
16657045
16657047
16657049
16657053
16657057
16657059
16657061
16657063
16657065
16657067
16657069
16657079
16657081
16657083
16657085
16657087
16657101
16657103
16657133
16657135
16657137
16657139
16657141
16657143
16657145
16657147
16657149
16657151
16657153
16657155
16857913
18671197
18671198
18671199
18671200
18671201
18671202
18671203
18671204
18671205
18671206
18671207
18671208
18671209
18671210
18671211
18671212
18671213
200072_PM_s_at
200072_s_at
214918_3p_at
214918_PM_at
214918_at
230392_PM_at
230392_at
233605_PM_x_at
233605_x_at
37717_at
3819544
3819545
3819546
3819550
3819561
3819562
3819566
3819567
3819568
3819569
3819570
3819571
3819572
3819573
3819574
3819577
3819578
3819579
3819582
3819583
3819584
3819585
3819586
3819592
3819593
3819595
3819596
3819597
3819599
3819600
3819601
3819602
3819603
3819604
3819605
3819606
3819607
3819608
3819609
3819653
3819655
3819657
3819659
3819663
3819665
3819667
3819669
3819671
3819673
3819689
3819691
3819707
3819709
3819711
3819713
3819715
3819757
3819771
3819773
3819775
4670
7892524
7892633
7892644
7892772
7893160
7893356
7893436
7893439
7893443
7893966
7894318
7894380
7894419
7894420
7894436
7894449
7894482
7894619
7894628
7894712
7894742
7894819
7894860
7894955
7894964
7894980
7895005
7895034
7895111
7895209
7895288
7895450
7895488
7895545
7895661
7895665
7895797
7895819
7895825
7895900
7895906
7896232
7896250
7896275
7896290
7896580
7896659
8025429
A_14_P131729
A_14_P137898
A_23_P16615
A_33_P3242919
GE81583
GO:0000380
GO:0000398
GO:0003676
GO:0003723
GO:0003729
GO:0005515
GO:0005634
GO:0005654
GO:0005681
GO:0005730
GO:0006397
GO:0008380
GO:0016020
GO:0016071
GO:0016363
GO:0019904
GO:0030312
GO:0031012
GO:0042382
GO:0043226
GO:0045202
GO:0062023
GO:0070062
GO:0071013
HMNXSV003007567
HMNXSV003036194
Hs.288823.0.A1_3p_at
Hs2.356878.1.A1_3p_at
ILMN_1745385
ILMN_1805371
L03532_at
PH_hs_0024371
TC19000151.hg
g3126877_3p_s_at
Participates
as a component of
hnRNP proteins [nucleoplasm] (Homo sapiens)
FGFR2 IIIb-specific splicing complex [nucleoplasm] (Homo sapiens)
as a member of
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
as an input of
ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression (Homo sapiens)
Inferred To
tial1 [nucleoplasm]
(Xenopus tropicalis)
HNRNPM [nucleoplasm]
(Caenorhabditis elegans)
HNRNPM [nucleoplasm]
(Dictyostelium discoideum)
Homologues of HNRNPM [nucleoplasm]
(Xenopus tropicalis)
rbm4b [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_112480.2
,
NP_005959.2
OpenTargets
ENSG00000099783
ENSEMBL
ENST00000325495
,
ENSP00000325732
,
ENSP00000325376
,
ENST00000348943
HPA
ENSG00000099783-HNRNPM
PRO
P52272
Pharos - Targets
P52272
GlyGen
P52272
PDB
2DH9
,
2DGV
,
2OT8
,
2DO0
Interactors (26)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P52597 HNRNPF
2
HNRNPF [nucleoplasm]
(R-HSA-71937)
HNRNPF [plasma membrane]
(R-HSA-8950714)
0.718
6
UniProt:P25791 LMO2
1
LMO2 [nucleoplasm]
(R-HSA-8956513)
0.666
4
UniProt:P31943 HNRNPH1
1
HNRNPH1 [nucleoplasm]
(R-HSA-71941)
0.666
4
UniProt:Q99459 CDC5L
1
CDC5L [nucleoplasm]
(R-HSA-5420887)
0.631
7
UniProt:Q92973 TNPO1
2
TNPO1 [cytosol]
(R-HSA-180743)
TNPO1 [cilium]
(R-HSA-5624896)
0.618
3
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.615
20
UniProt:O43660 PLRG1
1
PLRG1 [nucleoplasm]
(R-HSA-5420890)
0.613
5
UniProt:P22626 HNRNPA2B1
2
HNRNPA2B1 [nucleoplasm]
(R-HSA-71929)
HNRNPA2B1 [extracellular exosome]
(R-HSA-8950304)
0.564
2
UniProt:Q99558 MAP3K14
5
Active NIK [cytosol]
(R-HSA-5607646)
MAP3K14 [cytosol]
(R-HSA-168189)
p-MAP3K14 [cytosol]
(R-HSA-168187)
K48polyUb-NIK [cytosol]
(R-HSA-5668525)
p-T559-MAP3K14 [cytosol]
(R-HSA-5668531)
0.564
3
UniProt:O14964 HGS
2
HGS [cytosol]
(R-HSA-182954)
HGS [phagocytic vesicle lumen]
(R-HSA-9635660)
0.556
3
UniProt:P25800 LMO1
1
LMO1 [nucleoplasm]
(R-HSA-8956514)
0.556
3
IntAct:EBI-10178797 4005
0.556
3
UniProt:Q9BZW7 TSG10
0.556
3
UniProt:Q8WW24 TEKT4
0.556
3
UniProt:Q99996-2 AKAP9
0.556
3
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.556
3
UniProt:P43360 MAGA6
0.556
3
UniProt:P25791-3 LMO2
0.556
3
UniProt:Q8NEA9 GMCL2
0.556
3
UniProt:Q96PV6 LENG8
0.556
3
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.527
4
UniProt:Q96PV0 SYNGAP1
1
SYNGAP1 [cytosol]
(R-HSA-5658217)
0.527
3
UniProt:P35637 FUS
1
FUS [nucleoplasm]
(R-HSA-72040)
0.527
4
UniProt:Q8AZK7 EBNA5
0.499
2
UniProt:P26196 DDX6
1
DDX6 [cytosol]
(R-HSA-430032)
0.483
2
UniProt:P03372 ESR1
10
ESR1 [cytosol]
(R-HSA-9020968)
ESR1 [nucleoplasm]
(R-HSA-446168)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
0.462
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
