Reactome | SF3B1 [nucleoplasm]

SF3B1 [nucleoplasm]

Stable Identifier

R-HSA-71968

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SAP155, Splicing factor 3B subunit 1 (Spliceosome associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA splicing factor SF3b 155 kDa subunit), Splicing factor 3B subunit 1, Spliceosome associated protein 155, SAP 155, SF3b155, Pre-mRNA splicing factor SF3b 155 kDa subunit

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Locations in the PathwayBrowser for interactor UniProt:Q15029 EFTUD2

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External Reference Information

External Reference

UniProt:O75533 SF3B1

Gene Names

SF3B1, SAP155

Chain

chain:1-1304

Reference Genes

BioGPS Gene:23451 SF3B1

COSMIC (genes):SF3B1 SF3B1

CTD Gene:23451 SF3B1

dbSNP Gene:23451 SF3B1

ENSEMBL:ENSG00000115524 SF3B1

ENSEMBL_homo_sapiens_GENE:ENSG00000115524.17 SF3B1

HGNC:10768 SF3B1

KEGG Gene (Homo sapiens):23451 SF3B1

Monarch:23451 SF3B1

NCBI Gene:23451 SF3B1

OMIM:605590 SF3B1

UCSC:O75533 SF3B1

Reference Transcript

RefSeq:NM_012433.3 SF3B1

Other Identifiers

11716084_at

11716085_at

11745835_a_at

16906921

201070_PM_x_at

201070_x_at

201071_PM_x_at

201071_x_at

211185_PM_s_at

211185_s_at

214305_PM_s_at

214305_s_at

229303_PM_at

229303_at

23451

2593669

2593671

2593672

2593673

2593674

2593675

2593678

2593681

2593682

2593683

2593684

2593685

2593689

2593690

2593691

2593692

2593693

2593694

2593695

2593696

2593697

2593698

2593699

2593700

2593701

2593704

2593705

2593708

2593712

2593714

2593715

2593716

2593717

2593719

2593720

2593721

2593723

2593724

2593725

39444_at

51004_at

8058024

85475_at

A_32_P31633

GE61387

GE81798

GO:0000245

GO:0000375

GO:0000398

GO:0003723

GO:0003729

GO:0005515

GO:0005634

GO:0005654

GO:0005681

GO:0005684

GO:0005686

GO:0005689

GO:0005694

GO:0005730

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0006397

GO:0008380

GO:0016071

GO:0016607

GO:0034693

GO:0035066

GO:0036211

GO:0043226

GO:0045943

GO:0045944

GO:0045945

GO:0065003

GO:0071004

GO:0071005

GO:0071013

GO:0110016

GO:1903241

GO:1990935

HMNXSV003045547

Hs.13453.3.A1_3p_a_at

Hs.41136.0.A1_3p_at

ILMN_1674780

ILMN_1677165

ILMN_1706075

PH_hs_0016480

PH_hs_0032718

TC02002647.hg

g6912653_3p_a_at

Participates

as an input of

B-WICH complex binds rDNA promoter (Homo sapiens)

as a component of

Inferred To

Sf3b1 [nucleoplasm] (Drosophila melanogaster)

Sf3b1 [nucleoplasm] (Mus musculus)

Sf3b1 [nucleoplasm] (Rattus norvegicus)

Ghost homologue of SF3B1 [nucleoplasm] (Danio rerio)

prp10 [nucleoplasm] (Schizosaccharomyces pombe)

sftb-1 [nucleoplasm] (Caenorhabditis elegans)

SF3B1 [nucleoplasm] (Bos taurus)

SF3B1 [nucleoplasm] (Canis familiaris)

SF3B1 [nucleoplasm] (Gallus gallus)

SF3B1 [nucleoplasm] (Plasmodium falciparum)

SF3B1 [nucleoplasm] (Sus scrofa)

sf3b1 [nucleoplasm] (Dictyostelium discoideum)

sf3b1 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_036565.2

OpenTargets

ENSG00000115524

GeneCards

O75533

HPA

ENSG00000115524-SF3B1

Ensembl

ENST00000414963, ENSP00000428820, ENST00000409915, ENSP00000335321, ENSP00000402997, ENST00000335508, ENSG00000115524

PRO

O75533

Pharos - Targets

O75533

Orphanet

23049

PDB

5Z57, 5O9Z, 7B91, 6EN4, 2FHO, 7DVQ, 6Y50, 7OMF, 7SN6, 5ZYA, 7EVN, 7B92, 5Z56, 6N3E, 8CH6, 7OPI, 7Q3L, 5Z58, 7VPX, 7B0I, 7ABG, 6AHD, 6Y53, 6FF7, 7ONB, 8Y7E, 7B9C, 7Q4P, 2F9D, 8QO9, 6FF4, 3LQV, 7ABH, 6QX9, 6Y5Q, 4OZ1, 7QTT, 7EVO, 2PEH, 5IFE, 6AH0, 8HK1, 2F9J, 7ABI, 7Q4O

Interactors (41)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96I25 RBM17	1	RBM17 [nucleoplasm] (R-HSA-8865891)	0.842	7
UniProt:O75940 SMNDC1	1	SMNDC1 [nucleoplasm] (R-HSA-8865958)	0.731	5
UniProt:P63162 SNRPN	1	Me2-R108,R112-SNRPN [nucleoplasm] (R-HSA-8865931)	0.669	4
UniProt:Q96F63 CCD97			0.643	4
UniProt:Q7RTV0 PHF5A	1	PHF5A [nucleoplasm] (R-HSA-66652)	0.643	4
UniProt:P09661 SNRPA1	1	SNRPA1 [nucleoplasm] (R-HSA-71958)	0.643	5
UniProt:P62304 SNRPE	2	SNRPE [nucleoplasm] (R-HSA-71905) SNRPE [cytosol] (R-HSA-191782)	0.643	5
UniProt:Q8TBF4 ZCRB1	2	ZCRB1 [cytosol] (R-HSA-9682010) ZCRB1 [nucleoplasm] (R-HSA-6787853)	0.643	4
UniProt:Q15696 ZRSR2	1	ZRSR2 [nucleoplasm] (R-HSA-8865914)	0.643	5
UniProt:P62306 SNRPF	2	SNRPF [nucleoplasm] (R-HSA-71907) SNRPF [cytosol] (R-HSA-191852)	0.643	4
UniProt:O43143 DHX15	1	DHX15 [nucleoplasm] (R-HSA-5688097)	0.643	3
UniProt:Q9NY27 PPP4R2	1	PPP4R2 [nucleoplasm] (R-HSA-5687747)	0.569	3
UniProt:Q96DI7 SNRNP40	1	SNRNP40 [nucleoplasm] (R-HSA-71877)	0.564	2
UniProt:Q15428 SF3A2	1	SF3A2 [nucleoplasm] (R-HSA-71964)	0.564	3
UniProt:Q8TAD8 SNIP1	1	SNIP1 [nucleoplasm] (R-HSA-3222315)	0.553	2
UniProt:Q9Y3B4 SF3B6	1	SF3B6 [nucleoplasm] (R-HSA-83808)	0.547	3
UniProt:O43660 PLRG1	1	PLRG1 [nucleoplasm] (R-HSA-5420890)	0.547	2
UniProt:Q99459 CDC5L	1	CDC5L [nucleoplasm] (R-HSA-5420887)	0.527	2
UniProt:P08579 SNRPB2	1	SNRPB2 [nucleoplasm] (R-HSA-71960)	0.527	5
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.527	2
UniProt:Q13435 SF3B2	1	SF3B2 [nucleoplasm] (R-HSA-71971)	0.527	3
UniProt:Q15393 SF3B3	1	SF3B3 [nucleoplasm] (R-HSA-71973)	0.527	3
UniProt:Q15050 RRS1			0.527	2
UniProt:P61326 MAGOH	1	MAGOH [nucleoplasm] (R-HSA-156658)	0.527	2
UniProt:Q9GZS3 SKIC8	2	WDR61 [cytosol] (R-HSA-8931534) WDR61 [nucleoplasm] (R-HSA-8866696)	0.527	2
UniProt:P10412 H1-4	1	HIST1H1E [nucleoplasm] (R-HSA-211251)	0.527	2
UniProt:Q96HE9 PRR11			0.527	2
UniProt:P38919 EIF4A3	2	EIF4A3 [nucleoplasm] (R-HSA-8849149) EIF4A3 [cytosol] (R-HSA-927868)	0.527	2
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.527	3
UniProt:P14678 SNRPB	4	SNRPB [nucleoplasm] (R-HSA-71896) Me2-R108,R112-SNRPB [nucleoplasm] (R-HSA-192213) SNRPB [cytosol] (R-HSA-191798) 2xMe-SNRPB [cytosol] (R-HSA-192218)	0.527	4
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	4
UniProt:P15880 RPS2	3	RPS2 [nucleoplasm] (R-HSA-6790655) Me2aR-RPS2 [cytosol] (R-HSA-8879138) RPS2 [cytosol] (R-HSA-72347)	0.527	3
UniProt:O75937 DNAJC8	1	DNAJC8 [nucleoplasm] (R-HSA-53703)	0.527	3
UniProt:Q13936 CACNA1C	1	CACNA1C [plasma membrane] (R-HSA-265551)	0.499	2
UniProt:Q6ZN17 LN28B			0.483	2
UniProt:Q15427 SF3B4	1	SF3B4 [nucleoplasm] (R-HSA-71975)	0.483	3
UniProt:Q15029 EFTUD2	1	EFTUD2 [nucleoplasm] (R-HSA-71883)	0.483	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	7
UniProt:O75152 ZC3H11A	1	ZC3H11A [nucleoplasm] (R-HSA-8850659)	0.483	2
UniProt:P07910 HNRNPC	3	HNRNPC [cytosol] (R-HSA-9715136) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [nucleoplasm] (R-HSA-71933)	0.483	2
UniProt:Q9UJV9 DDX41	4	DDX41 [nucleoplasm] (R-HSA-9769601) DDX41 [cytosol] (R-HSA-3134807) K48polyUb-DDX41 [cytosol] (R-HSA-3134942) K48polyUb-DDX41 [cytosol] (R-HSA-3134941)	0.462	3

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