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CPSF1 [nucleoplasm]
Stable Identifier
R-HSA-71989
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
CPSA_HUMAN, Cleavage and polyadenylation specificity factor, 160 kDa subunit, CPSF 160 kDa subunit, CPSF160
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA Polymerase II Transcription Termination (Homo sapiens)
Cleavage of Intronless Pre-mRNA at 3'-end (Homo sapiens)
intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF1 [nucleoplasm] (Homo sapiens)
upstream mRNA fragment:CPSF:PAP:PABPN1 complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF1 [nucleoplasm] (Homo sapiens)
Cleavage of mRNA at the 3'-end (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF1 [nucleoplasm] (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF1 [nucleoplasm] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
Formation of the Cleavage and Polyadenylation Complex (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF1 [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF1 [nucleoplasm] (Homo sapiens)
Transport of Mature Transcript to Cytoplasm (Homo sapiens)
Transport of Mature mRNAs Derived from Intronless Transcripts (Homo sapiens)
Transport of Mature mRNA Derived from an Intronless Transcript (Homo sapiens)
Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF1 [nucleoplasm] (Homo sapiens)
Mature intronless derived mRNA complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF1 [nucleoplasm] (Homo sapiens)
mRNA 3'-end processing (Homo sapiens)
Cleavage of mRNA at the 3'-end (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF1 [nucleoplasm] (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF1 [nucleoplasm] (Homo sapiens)
TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF1 [nucleoplasm] (Homo sapiens)
Spliced mRNP [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF1 [nucleoplasm] (Homo sapiens)
mRNA polyadenylation (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF1 [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF1 [nucleoplasm] (Homo sapiens)
Processing of Capped Intronless Pre-mRNA (Homo sapiens)
Processing of Intronless Pre-mRNAs (Homo sapiens)
Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Homo sapiens)
CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF1 [nucleoplasm] (Homo sapiens)
intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF1 [nucleoplasm] (Homo sapiens)
Cleavage and polyadenylation of Intronless Pre-mRNA (Homo sapiens)
Mature intronless derived mRNA complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF1 [nucleoplasm] (Homo sapiens)
intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF1 [nucleoplasm] (Homo sapiens)
Cleavage of Intronless Pre-mRNA at 3'-end (Homo sapiens)
intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF1 [nucleoplasm] (Homo sapiens)
upstream mRNA fragment:CPSF:PAP:PABPN1 complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF1 [nucleoplasm] (Homo sapiens)
Recognition of AAUAAA sequence by CPSF (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF1 [nucleoplasm] (Homo sapiens)
CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF1 [nucleoplasm] (Homo sapiens)
Recruitment of CstF to the CPSF Bound Pre-mRNA (Homo sapiens)
CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF1 [nucleoplasm] (Homo sapiens)
CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF1 [nucleoplasm] (Homo sapiens)
tRNA processing (Homo sapiens)
tRNA processing in the nucleus (Homo sapiens)
TSEN complex cleaves the intron from pre-tRNA (Homo sapiens)
TSEN complex [nucleoplasm] (Homo sapiens)
CPSF1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q10570 CPSF1
Gene Names
CPSF1, CPSF160
Chain
chain:1-1443
Reference Genes
BioGPS Gene:29894 CPSF1
COSMIC (genes):CPSF1 CPSF1
CTD Gene:29894 CPSF1
dbSNP Gene:29894 CPSF1
ENSEMBL:ENSG00000071894 CPSF1
HGNC:2324 CPSF1
KEGG:hsa:29894 CPSF1
Monarch:29894 CPSF1
NCBI Gene:29894 CPSF1
OMIM:606027 CPSF1
UCSC:Q10570 CPSF1
Reference Transcript
RefSeq:NM_013291.2 CPSF1
Other Identifiers
11720093_at
11747849_a_at
11747850_x_at
11755358_a_at
17082604
17082653
17119710
201638_PM_s_at
201638_s_at
201639_PM_s_at
201639_s_at
29894
3158517
3158518
3158519
3158520
3158521
3158522
3158523
3158524
3158525
3158526
3158527
3158528
3158529
3158530
3158531
3158532
3158533
3158534
3158535
3158536
3158537
3158538
3158539
3158540
3158541
3158542
3158544
3158545
3158546
3158547
3158548
3158549
3158550
3158551
3158552
3158553
3158554
3158555
3158556
3158557
3158558
3158559
3158560
3158561
3158562
3158563
3158564
3158565
3158566
3158567
3158568
3158574
3158575
3158576
33132_PM_at
33132_at
3943326
3943329
3943332
8153727
A_23_P169112
GE59110
GO:0003676
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005847
GO:0006397
GO:0016071
GO:0019899
GO:0035925
GO:0043226
GO:0180012
HMNXSV003044075
HMNXSV003044428
HMNXSV003048792
Hs.83727.0.A1_3p_a_at
Hs.83727.0.A1_3p_s_at
ILMN_1654545
PH_hs_0027719
TC08001748.hg
U37012_at
g9558724_3p_s_at
Participates
as a component of
TSEN complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
Inferred To
CFT1 [nucleoplasm]
(Saccharomyces cerevisiae)
cft1 [nucleoplasm]
(Schizosaccharomyces pombe)
cpsf-1 [nucleoplasm]
(Caenorhabditis elegans)
Cpsf1 [nucleoplasm]
(Mus musculus)
Cpsf1 [nucleoplasm]
(Rattus norvegicus)
Ghost homologue of CPSF1 [nucleoplasm]
(Gallus gallus)
Ghost homologue of CPSF1 [nucleoplasm]
(Sus scrofa)
Ghost homologue of CPSF1 [nucleoplasm]
(Xenopus tropicalis)
CPSF1 [nucleoplasm]
(Bos taurus)
CPSF1 [nucleoplasm]
(Canis familiaris)
Cpsf160 [nucleoplasm]
(Drosophila melanogaster)
cpsf1 [nucleoplasm]
(Danio rerio)
cpsf1 [nucleoplasm]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_037423.2
ENSEMBL
ENSP00000495102
,
ENSP00000495020
,
ENSP00000484669
,
ENST00000643746
,
ENST00000644539
,
ENSP00000478145
,
ENST00000620219
,
ENST00000616140
OpenTargets
ENSG00000071894
HPA
ENSG00000071894-CPSF1
PRO
Q10570
Pharos - Targets
Q10570
GlyGen
Q10570
PDB
6BM0
,
8E3I
,
6URO
,
8R8R
,
6URG
,
6F9N
,
8E3Q
,
6DNH
,
6BLY
,
6FUW
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O95639 CPSF4
1
CPSF4 [nucleoplasm]
(R-HSA-169104)
0.564
2
UniProt:P06748 NPM1
11
NPM1 [cytosol]
(R-HSA-3008211)
p-S4-NPM1 [cytosol]
(R-HSA-6801679)
NPM1 [nucleoplasm]
(R-HSA-606320)
NPM1 [granular component]
(R-HSA-9017702)
NPM1(1-117)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699834)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699861)
NPM1(1-117)-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730697)
NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730703)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm]
(R-HSA-9725010)
polySUMO2,3-K263-NPM1 [nucleoplasm]
(R-HSA-4086056)
monoSUMO1-K263-NPM1 [nucleoplasm]
(R-HSA-4086039)
0.499
2
UniProt:Q6P1J9 CDC73
1
CDC73 [nucleoplasm]
(R-HSA-3322360)
0.499
4
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