Reactome | CPSF1 [nucleoplasm]

CPSF1 [nucleoplasm]

Stable Identifier

R-HSA-71989

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

CPSA_HUMAN, Cleavage and polyadenylation specificity factor, 160 kDa subunit, CPSF 160 kDa subunit

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA Polymerase II Transcription Termination (Homo sapiens)
    - Cleavage of Intronless Pre-mRNA at 3'-end (Homo sapiens)
      - intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
        
        CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        CPSF1 [nucleoplasm] (Homo sapiens)
      - upstream mRNA fragment:CPSF:PAP:PABPN1 complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        CPSF1 [nucleoplasm] (Homo sapiens)
    - Cleavage of mRNA at the 3'-end (Homo sapiens)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        CPSF1 [nucleoplasm] (Homo sapiens)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
        
        Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        CPSF1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q10570 CPSF1

Gene Names

CPSF1, CPSF160

Chain

chain:1-1443

Reference Genes

BioGPS Gene:29894 CPSF1

CTD Gene:29894 CPSF1

dbSNP Gene:29894 CPSF1

ENSEMBL:ENSG00000071894 CPSF1

ENSEMBL:ENSG00000285049 CPSF1

HGNC:2324 CPSF1

KEGG Gene (Homo sapiens):29894 CPSF1

Monarch:29894 CPSF1

NCBI Gene:29894 CPSF1

OMIM:606027 CPSF1

UCSC:Q10570 CPSF1

Reference Transcript

RefSeq:NM_013291.2 CPSF1

Other Identifiers

0001660673

11720093_at

11747849_a_at

11747850_x_at

11755358_a_at

17082604

201638_s_at

201639_s_at

29894

3158517

3158518

3158519

3158520

3158522

3158524

3158526

3158529

3158530

3158531

3158532

3158533

3158534

3158536

3158538

3158539

3158540

3158541

3158542

3158544

3158545

3158546

3158548

3158549

3158550

3158551

3158552

3158554

3158556

3158557

3158559

3158560

3158562

3158563

3158564

3158565

3158566

3158567

3158568

3158574

3158575

3158576

33132_at

3943326

3943329

3943332

8153727

A_23_P169112

GE59110

GO:0000398

GO:0003674

GO:0003676

GO:0003723

GO:0003729

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005847

GO:0006369

GO:0006378

GO:0006388

GO:0006397

GO:0006399

GO:0006406

GO:0006810

GO:0006913

GO:0008150

GO:0009058

GO:0015031

GO:0019899

GO:0031124

GO:0032991

GO:0034641

GO:0035925

GO:0043226

GO:0098789

Hs.83727.0.A1_3p_a_at

Hs.83727.0.A1_3p_s_at

ILMN_1654545

PH_hs_0027719

TC08001748.hg

U37012_at

g9558724_3p_s_at

Participant Of

hasComponent

Inferred To

CFT1 [nucleoplasm] (Saccharomyces cerevisiae)

cft1 [nucleoplasm] (Schizosaccharomyces pombe)

cpsf-1 [nucleoplasm] (Caenorhabditis elegans)

Cpsf1 [nucleoplasm] (Mus musculus)

Cpsf1 [nucleoplasm] (Rattus norvegicus)

Ghost homologue of CPSF1 [nucleoplasm] (Gallus gallus)

Ghost homologue of CPSF1 [nucleoplasm] (Xenopus tropicalis)

CPSF1 [nucleoplasm] (Bos taurus)

CPSF1 [nucleoplasm] (Canis familiaris)

CPSF1 [nucleoplasm] (Dictyostelium discoideum)

CPSF1 [nucleoplasm] (Sus scrofa)

Cpsf160 [nucleoplasm] (Drosophila melanogaster)

cpsf1 [nucleoplasm] (Danio rerio)

Cross References

RefSeq

NP_037423.2

Target Pathogen

5b354852be737e166372ec7a

OpenTargets

ENSG00000071894

GeneCards

Q10570

HPA

ENSG00000071894-CPSF1

Ensembl

ENST00000644539, ENSG00000285049, ENSP00000484669, ENSP00000495020, ENSP00000478145, ENST00000620219, ENST00000616140, ENSG00000071894, ENSP00000495102, ENST00000643746

PRO

Q10570

Orphanet

24436

PDB

6F9N, 6URG, 6FBS, 6BM0, 6FUW, 6BLY, 6DNH, 6URO

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q6P1J9 CDC73	1	CDC73 [nucleoplasm] (R-HSA-3322360)	0.499	4
UniProt:P06748 NPM1	5	p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [cytosol] (R-HSA-3008211) NPM1 [nucleoplasm] (R-HSA-606320) SUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) SUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.499	2

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