Reactome | CSTF2 [nucleoplasm]

CSTF2 [nucleoplasm]

Stable Identifier

R-HSA-72003

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

CSTF 64 kDa subunit, CST2_HUMAN, Cleavage stimulation factor, 64 kDa subunit, CF-1 64 kDa subunit

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA Polymerase II Transcription Termination (Homo sapiens)
    - Cleavage of Intronless Pre-mRNA at 3'-end (Homo sapiens)
      - CstF [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
      - intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
        
        CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        CstF [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
    - Cleavage of mRNA at the 3'-end (Homo sapiens)
      - CstF [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
        
        Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
        
        CstF [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P33240 CSTF2

Gene Names

CSTF2

Chain

chain:1-577

Reference Genes

BioGPS Gene:1478 CSTF2

COSMIC (genes):CSTF2 CSTF2

CTD Gene:1478 CSTF2

dbSNP Gene:1478 CSTF2

ENSEMBL:ENSG00000101811 CSTF2

HGNC:2484 CSTF2

KEGG:hsa:1478 CSTF2

Monarch:1478 CSTF2

NCBI Gene:1478 CSTF2

OMIM:300907 CSTF2

UCSC:P33240 CSTF2

Reference Transcript

Other Identifiers

11722402_a_at

11759641_at

1478

17105347

204459_PM_at

204459_at

238821_PM_at

238821_at

3984540

3984541

3984542

3984543

3984544

3984545

3984547

3984548

3984549

3984552

3984553

3984554

3984555

3984556

3984557

3984560

3984561

3984562

3984563

3984564

3984565

3984567

3984569

3984572

3984573

3984574

40334_at

74305_at

8168762

A_23_P148372

GE62616

GO:0003676

GO:0003723

GO:0003729

GO:0005515

GO:0005634

GO:0005654

GO:0005847

GO:0006397

GO:0016071

GO:0016604

GO:0031124

GO:0043226

GO:0071920

GO:1990090

HMNXSV003009323

HMNXSV003047998

Hs.128578.0.A1_3p_at

ILMN_1653129

M85085_at

PH_hs_0025238

TC0X000470.hg

g4557492_3p_at

Participates

as a component of

TSEN complex [nucleoplasm] (Homo sapiens)

as a member of

CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)

Inferred To

CSTF2 [nucleoplasm] (Bos taurus)

CSTF2 [nucleoplasm] (Canis familiaris)

CSTF2 [nucleoplasm] (Gallus gallus)

CSTF2 [nucleoplasm] (Sus scrofa)

cstf2 [nucleoplasm] (Dictyostelium discoideum)

Cstf2 [nucleoplasm] (Mus musculus)

Cstf2 [nucleoplasm] (Rattus norvegicus)

cpf-2 [nucleoplasm] (Caenorhabditis elegans)

RNA15 [nucleoplasm] (Saccharomyces cerevisiae)

ctf1 [nucleoplasm] (Schizosaccharomyces pombe)

CstF64 [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_001316.1, NP_001293138.1

ENSEMBL

ENSP00000362063, ENST00000372972

OpenTargets

ENSG00000101811

HPA

ENSG00000101811-CSTF2

PRO

P33240

Pharos - Targets

P33240

GlyGen

P33240

PDB

1P1T, 6Q2I, 6TZE, 2J8P

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14964 HGS	2	HGS [cytosol] (R-HSA-182954) HGS [phagocytic vesicle lumen] (R-HSA-9635660)	0.718	6
UniProt:Q99728 BARD1	13	K6PolyUb,p-T714,T734-BARD1 [nucleoplasm] (R-HSA-9707286) p-T714,T734-BARD1 [nucleoplasm] (R-HSA-5659846) BARD1 [nucleoplasm] (R-HSA-5659775) K6PolyUb-BARD1 [nucleoplasm] (R-HSA-9701024) BARD1 C83G [nucleoplasm] (R-HSA-9699139) BARD1 C50G [nucleoplasm] (R-HSA-9699137) BARD1 L44R [nucleoplasm] (R-HSA-9699126) BARD1 H68Y [nucleoplasm] (R-HSA-9699151) BARD1 W34R [nucleoplasm] (R-HSA-9699166) BARD1 G623W [nucleoplasm] (R-HSA-9699148) BARD1 C53W [nucleoplasm] (R-HSA-9700807) BARD1 C71Y [nucleoplasm] (R-HSA-9700808) BARD1 G623E [nucleoplasm] (R-HSA-9699135)	0.702	8
UniProt:Q6P1J9 CDC73	1	CDC73 [nucleoplasm] (R-HSA-3322360)	0.576	5
UniProt:Q9ULX6 AKAP8L	1	AKAP8L [nucleoplasm] (R-HSA-9821364)	0.556	3
UniProt:O95453 PARN	1	PARN [cytosol] (R-HSA-430009)	0.499	5