Reactome | CSTF2 [nucleoplasm]

CSTF2 [nucleoplasm]

Stable Identifier

R-HSA-72003

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

CSTF 64 kDa subunit, CST2_HUMAN, Cleavage stimulation factor, 64 kDa subunit, CF-1 64 kDa subunit

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Dengue Virus Infection (Homo sapiens)
      - Dengue Virus-Host Interactions (Homo sapiens)
        
        NS5 interacts with Spliceosome (Homo sapiens)
        
        NS5:Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
        
        Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
        
        CSTF hexamer [nucleoplasm] (Homo sapiens)
        
        CSTF heterotrimer [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
        
        Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
        
        CSTF hexamer [nucleoplasm] (Homo sapiens)
        
        CSTF heterotrimer [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
  - mRNA 3'-end processing (Homo sapiens)
    - TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Homo sapiens)
      - Spliced mRNP [nucleoplasm] (Homo sapiens)
        
        Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
        
        CSTF hexamer [nucleoplasm] (Homo sapiens)
        
        CSTF heterotrimer [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
    - mRNA Polyadenylation (Homo sapiens)
      - CPA complex components dissociate from polyadenylated pre-mRNA (distal 3'UTR PAS) (Homo sapiens)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA complex [nucleoplasm] (Homo sapiens)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Homo sapiens)
        
        CSTF hexamer [nucleoplasm] (Homo sapiens)
        
        CSTF heterotrimer [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Homo sapiens)
        
        CSTF hexamer [nucleoplasm] (Homo sapiens)
        
        CSTF heterotrimer [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
      - CPA complex components dissociate from polyadenylated pre-mRNA (intronic PAS) (Homo sapiens)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA complex [nucleoplasm] (Homo sapiens)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Homo sapiens)
        
        CSTF hexamer [nucleoplasm] (Homo sapiens)
        
        CSTF heterotrimer [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Homo sapiens)
        
        CSTF hexamer [nucleoplasm] (Homo sapiens)
        
        CSTF heterotrimer [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
      - CPA complex components dissociate from polyadenylated pre-mRNA (proximal 3'UTR PAS) (Homo sapiens)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA complex [nucleoplasm] (Homo sapiens)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Homo sapiens)
        
        CSTF hexamer [nucleoplasm] (Homo sapiens)
        
        CSTF heterotrimer [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Homo sapiens)
        
        CSTF hexamer [nucleoplasm] (Homo sapiens)
        
        CSTF heterotrimer [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
      - CPSF3 cleaves pre-mRNA at distal 3'UTR PAS (Homo sapiens)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA complex [nucleoplasm] (Homo sapiens)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Homo sapiens)
        
        CSTF hexamer [nucleoplasm] (Homo sapiens)
        
        CSTF heterotrimer [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA complex [nucleoplasm] (Homo sapiens)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Homo sapiens)
        
        CSTF hexamer [nucleoplasm] (Homo sapiens)
        
        CSTF heterotrimer [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
      - CPSF3 cleaves pre-mRNA at proximal 3'UTR PAS (Homo sapiens)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA complex [nucleoplasm] (Homo sapiens)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Homo sapiens)
        
        CSTF hexamer [nucleoplasm] (Homo sapiens)
        
        CSTF heterotrimer [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA complex [nucleoplasm] (Homo sapiens)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Homo sapiens)
        
        CSTF hexamer [nucleoplasm] (Homo sapiens)
        
        CSTF heterotrimer [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
      - Core CPA complex binds capped pre-mRNA (Homo sapiens)
        
        Core CPA complex [nucleoplasm] (Homo sapiens)
        
        CSTF hexamer [nucleoplasm] (Homo sapiens)
        
        CSTF heterotrimer [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Homo sapiens)
        
        Core CPA complex [nucleoplasm] (Homo sapiens)
        
        CSTF hexamer [nucleoplasm] (Homo sapiens)
        
        CSTF heterotrimer [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
      - Formation of the CSTF complex (Homo sapiens)
        
        CSTF hexamer [nucleoplasm] (Homo sapiens)
        
        CSTF heterotrimer [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
      - Formation of the core cleavage and polyadenylation complex (Homo sapiens)
        
        CSTF hexamer [nucleoplasm] (Homo sapiens)
        
        CSTF heterotrimer [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
        
        Core CPA complex [nucleoplasm] (Homo sapiens)
        
        CSTF hexamer [nucleoplasm] (Homo sapiens)
        
        CSTF heterotrimer [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at distal 3'UTR PAS (Homo sapiens)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA complex [nucleoplasm] (Homo sapiens)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Homo sapiens)
        
        CSTF hexamer [nucleoplasm] (Homo sapiens)
        
        CSTF heterotrimer [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA complex [nucleoplasm] (Homo sapiens)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Homo sapiens)
        
        CSTF hexamer [nucleoplasm] (Homo sapiens)
        
        CSTF heterotrimer [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at intronic PAS (Homo sapiens)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA complex [nucleoplasm] (Homo sapiens)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Homo sapiens)
        
        CSTF hexamer [nucleoplasm] (Homo sapiens)
        
        CSTF heterotrimer [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA complex [nucleoplasm] (Homo sapiens)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Homo sapiens)
        
        CSTF hexamer [nucleoplasm] (Homo sapiens)
        
        CSTF heterotrimer [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at proximal 3'UTR PAS (Homo sapiens)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA complex [nucleoplasm] (Homo sapiens)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Homo sapiens)
        
        CSTF hexamer [nucleoplasm] (Homo sapiens)
        
        CSTF heterotrimer [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA complex [nucleoplasm] (Homo sapiens)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Homo sapiens)
        
        CSTF hexamer [nucleoplasm] (Homo sapiens)
        
        CSTF heterotrimer [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
      - PP1 dephosphorylates RNA Pol II (Homo sapiens)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Homo sapiens)
        
        CPA complex [nucleoplasm] (Homo sapiens)
        
        Core CPA complex [nucleoplasm] (Homo sapiens)
        
        CSTF hexamer [nucleoplasm] (Homo sapiens)
        
        CSTF heterotrimer [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        CPA complex [nucleoplasm] (Homo sapiens)
        
        Core CPA complex [nucleoplasm] (Homo sapiens)
        
        CSTF hexamer [nucleoplasm] (Homo sapiens)
        
        CSTF heterotrimer [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
      - RBBP6 activates CPSF complex (Homo sapiens)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        CPA complex [nucleoplasm] (Homo sapiens)
        
        Core CPA complex [nucleoplasm] (Homo sapiens)
        
        CSTF hexamer [nucleoplasm] (Homo sapiens)
        
        CSTF heterotrimer [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA complex [nucleoplasm] (Homo sapiens)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Homo sapiens)
        
        CSTF hexamer [nucleoplasm] (Homo sapiens)
        
        CSTF heterotrimer [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
      - Recruitment of other CPA components to pre-mRNA-bound CPA core (Homo sapiens)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Homo sapiens)
        
        CPA complex [nucleoplasm] (Homo sapiens)
        
        Core CPA complex [nucleoplasm] (Homo sapiens)
        
        CSTF hexamer [nucleoplasm] (Homo sapiens)
        
        CSTF heterotrimer [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Homo sapiens)
        
        Core CPA complex [nucleoplasm] (Homo sapiens)
        
        CSTF hexamer [nucleoplasm] (Homo sapiens)
        
        CSTF heterotrimer [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
      - U1 snRNP suppresses CPSF3-mediated pre-mRNA cleavage at intronic PAS (Homo sapiens)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA complex [nucleoplasm] (Homo sapiens)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Homo sapiens)
        
        CSTF hexamer [nucleoplasm] (Homo sapiens)
        
        CSTF heterotrimer [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA complex [nucleoplasm] (Homo sapiens)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Homo sapiens)
        
        CSTF hexamer [nucleoplasm] (Homo sapiens)
        
        CSTF heterotrimer [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
- Processing of Capped Intronless Pre-mRNA (Homo sapiens)
  - Processing of Intronless Pre-mRNAs (Homo sapiens)
    - Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Homo sapiens)
      - CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        CSTF heterotrimer [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
      - intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
        
        CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        CSTF heterotrimer [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
    - Cleavage and polyadenylation of Intronless Pre-mRNA (Homo sapiens)
      - CSTF heterotrimer [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
      - intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
        
        CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        CSTF heterotrimer [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
    - Cleavage of Intronless Pre-mRNA at 3'-end (Homo sapiens)
      - CSTF heterotrimer [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
      - intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
        
        CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        CSTF heterotrimer [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
    - Recruitment of CstF to the CPSF Bound Pre-mRNA (Homo sapiens)
      - CSTF heterotrimer [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
      - CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        CSTF heterotrimer [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)
- tRNA processing (Homo sapiens)
  - tRNA processing in the nucleus (Homo sapiens)
    - TSEN complex cleaves the intron from pre-tRNA (Homo sapiens)
      - TSEN complex [nucleoplasm] (Homo sapiens)
        
        CSTF2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P33240 CSTF2

Gene Names

CSTF2

Chain

chain:1-577

Reference Genes

BioGPS Gene:1478 CSTF2

COSMIC (genes):CSTF2 CSTF2

CTD Gene:1478 CSTF2

dbSNP Gene:1478 CSTF2

ENSEMBL:ENSG00000101811 CSTF2

HGNC:2484 CSTF2

KEGG:hsa:1478 CSTF2

Monarch:1478 CSTF2

NCBI Gene:1478 CSTF2

OMIM:300907 CSTF2

UCSC:P33240 CSTF2

Reference Transcript

Other Identifiers

11722402_a_at

11759641_at

1478

17105347

204459_PM_at

204459_at

238821_PM_at

238821_at

3984540

3984541

3984542

3984543

3984544

3984545

3984547

3984548

3984549

3984552

3984553

3984554

3984555

3984556

3984557

3984559

3984560

3984561

3984562

3984563

3984564

3984565

3984567

3984569

3984570

3984571

3984572

3984573

3984574

40334_at

74305_at

8168762

A_23_P148372

GE62616

GO:0003676

GO:0003723

GO:0003729

GO:0005515

GO:0005634

GO:0005654

GO:0005847

GO:0006397

GO:0016071

GO:0016604

GO:0031124

GO:0071920

GO:1990090

HMNXSV003009323

HMNXSV003047998

Hs.128578.0.A1_3p_at

ILMN_1653129

M85085_at

PH_hs_0025238

TC0X000470.hg

g4557492_3p_at

Participates

as a component of

TSEN complex [nucleoplasm] (Homo sapiens)

as a member of

CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)

Inferred To

CSTF2 [nucleoplasm] (Bos taurus)

CSTF2 [nucleoplasm] (Canis familiaris)

CSTF2 [nucleoplasm] (Gallus gallus)

CSTF2 [nucleoplasm] (Plasmodium falciparum)

CSTF2 [nucleoplasm] (Sus scrofa)

cstf2 [nucleoplasm] (Danio rerio)

cstf2 [nucleoplasm] (Dictyostelium discoideum)

Cstf2 [nucleoplasm] (Mus musculus)

Cstf2 [nucleoplasm] (Rattus norvegicus)

cpf-2 [nucleoplasm] (Caenorhabditis elegans)

RNA15 [nucleoplasm] (Saccharomyces cerevisiae)

ctf1 [nucleoplasm] (Schizosaccharomyces pombe)

CstF64 [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_001293138.1, NP_001316.1

ENSEMBL

ENSG00000101811, ENSP00000362063, ENST00000372972

OpenTargets

ENSG00000101811

GeneCards

CSTF2

HPA

ENSG00000101811-CSTF2

PRO

P33240

Pharos - Targets

P33240

GlyGen

P33240

PDB

1P1T, 2J8P, 6Q2I, 6TZE

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14964 HGS	2	HGS [cytosol] (R-HSA-182954) HGS [phagocytic vesicle lumen] (R-HSA-9635660)	0.718	6
UniProt:Q99728 BARD1	13	K6PolyUb,p-T714,T734-BARD1 [nucleoplasm] (R-HSA-9707286) p-T714,T734-BARD1 [nucleoplasm] (R-HSA-5659846) BARD1 [nucleoplasm] (R-HSA-5659775) K6PolyUb-BARD1 [nucleoplasm] (R-HSA-9701024) BARD1 C83G [nucleoplasm] (R-HSA-9699139) BARD1 C50G [nucleoplasm] (R-HSA-9699137) BARD1 L44R [nucleoplasm] (R-HSA-9699126) BARD1 H68Y [nucleoplasm] (R-HSA-9699151) BARD1 W34R [nucleoplasm] (R-HSA-9699166) BARD1 G623W [nucleoplasm] (R-HSA-9699148) BARD1 C53W [nucleoplasm] (R-HSA-9700807) BARD1 C71Y [nucleoplasm] (R-HSA-9700808) BARD1 G623E [nucleoplasm] (R-HSA-9699135)	0.702	8
UniProt:Q6P1J9 CDC73	1	CDC73 [nucleoplasm] (R-HSA-3322360)	0.576	5
UniProt:O75177 SS18L1	1	SS18L1 [nucleoplasm] (R-HSA-9727481)	0.556	3
UniProt:Q9ULX6 AKAP8L	1	AKAP8L [nucleoplasm] (R-HSA-9821364)	0.556	3
UniProt:Q9P2I0 CPSF2	1	CPSF2 [nucleoplasm] (R-HSA-71991)	0.499	2
UniProt:Q92797 SYMPK	1	SYMPK [nucleoplasm] (R-HSA-4615988)	0.499	2
UniProt:O95453 PARN	1	PARN [cytosol] (R-HSA-430009)	0.499	5

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