Reactome | NUDT21 [nucleoplasm]

NUDT21 [nucleoplasm]

Stable Identifier

R-HSA-72010

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

CF I - 25 kDa subunit, Cleavage Factor I 25 kDa subunit, CPSF5, CFIm25

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Dengue Virus Infection (Homo sapiens)
      - Dengue Virus-Host Interactions (Homo sapiens)
        
        NS5 interacts with Spliceosome (Homo sapiens)
        
        NS5:Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
        
        Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
        
        CF I [nucleoplasm] (Homo sapiens)
        
        NUDT21 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
        
        Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
        
        CF I [nucleoplasm] (Homo sapiens)
        
        NUDT21 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O43809 NUDT21

Gene Names

NUDT21, CFIM25, CPSF25, CPSF5

Chain

initiator methionine:1, chain:2-227

Reference Genes

BioGPS Gene:11051 NUDT21

COSMIC (genes):NUDT21 NUDT21

CTD Gene:11051 NUDT21

dbSNP Gene:11051 NUDT21

ENSEMBL:ENSG00000167005 NUDT21

HGNC:13870 NUDT21

KEGG:hsa:11051 NUDT21

Monarch:11051 NUDT21

NCBI Gene:11051 NUDT21

OMIM:604978 NUDT21

UCSC:O43809 NUDT21

Reference Transcript

RefSeq:NM_007006.3 NUDT21

Other Identifiers

11051

11718401_a_at

11718402_a_at

11756899_a_at

16826708

202697_PM_at

202697_at

213461_3p_at

213461_PM_at

213461_at

224830_PM_at

224830_at

3692894

3692896

3692897

3692898

3692899

3692900

3692901

3692902

3692903

3692904

3692905

3692908

3692909

3692912

3692913

3692914

3692915

3692916

3692917

3692918

3692919

3692920

39142_at

4048119

64044_at

8001496

80880_at

90992_at

A_23_P129614

A_24_P287756

A_33_P3418942

GE55148

GE86161

GO:0003682

GO:0003723

GO:0003729

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005847

GO:0005849

GO:0006397

GO:0010608

GO:0016071

GO:0016604

GO:0030154

GO:0031124

GO:0034451

GO:0035925

GO:0042382

GO:0042802

GO:0042803

GO:0042826

GO:0051262

GO:0051290

GO:0065003

GO:0110104

GO:0180010

GO:2000738

GO:2000975

HMNXSV003003268

Hs.288061.1.S1_3p_at

Hs.288061.1.S1_3p_s_at

Hs.288061.1.S1_3p_x_at

Hs.301528.1.A1_3p_at

ILMN_1798886

ILMN_2133146

PH_hs_0026091

TC16001133.hg

g5901925_3p_at

Participates

as a component of

as an input of

NUDT21 dimerizes (Homo sapiens)

This entity regulates

Positively

CPSF3 cleaves pre-mRNA at distal 3'UTR PAS (Homo sapiens)

Inferred To

Cpsf5 [nucleoplasm] (Drosophila melanogaster)

cfim-1 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of NUDT21 [nucleoplasm] (Schizosaccharomyces pombe)

NUDT21 [nucleoplasm] (Bos taurus)

NUDT21 [nucleoplasm] (Canis familiaris)

NUDT21 [nucleoplasm] (Gallus gallus)

NUDT21 [nucleoplasm] (Plasmodium falciparum)

NUDT21 [nucleoplasm] (Sus scrofa)

nudt21 [nucleoplasm] (Danio rerio)

nudt21 [nucleoplasm] (Dictyostelium discoideum)

nudt21 [nucleoplasm] (Xenopus tropicalis)

Nudt21 [nucleoplasm] (Mus musculus)

Nudt21 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_008937.1

OpenTargets

ENSG00000167005

ENSEMBL

ENST00000300291, ENSG00000167005, ENSP00000300291

HPA

ENSG00000167005-NUDT21

GeneCards

NUDT21

PRO

O43809

Pharos - Targets

O43809

GlyGen

O43809

PDB

5R4P, 5R4R, 2J8Q, 3P6Y, 3Q2T, 5R67, 3BAP, 3N9U, 3MDI, 5R4U, 3Q2S, 3BHO, 5R65, 2CL3, 5R4T, 5R4S, 3MDG, 5R66, 5R4Q, 5R64, 3P5T

Interactors (31)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16630 CPSF6	2	CPSF6(1-490)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1838987) CPSF6(1-490)-FGFR1(429-822) fusion [cytosol] (R-HSA-1614368)	0.889	10
UniProt:O43809 NUDT21	1	NUDT21 [nucleoplasm] (R-HSA-72010)	0.809	6
UniProt:Q8N684 CPSF7	2	CPSF7 [nucleoplasm] (R-HSA-72012) CPSF7 [cytosol] (R-HSA-9715140)	0.743	5
UniProt:Q16630-2 CPSF6	1	CPSF6-2 [nucleoplasm] (R-HSA-72014)	0.742	7
UniProt:P60660 MYL6	2	p-S20-MYL6 [cytosol] (R-HSA-445778) MYL6 [cytosol] (R-HSA-419186)	0.742	5
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.718	6
UniProt:P54253 ATX1			0.703	8
UniProt:Q16630-1 CPSF6	1	CPSF6-1 [nucleoplasm] (R-HSA-72013)	0.655	4
UniProt:Q15287 RNPS1	2	RNPS1 [nucleoplasm] (R-HSA-156778) RNPS1 [cytosol] (R-HSA-159256)	0.564	2
UniProt:Q9UGI0 ZRANB1	1	ZRANB1 [cytosol] (R-HSA-6781939)	0.556	3
UniProt:Q96HA8 NTAQ1			0.556	5
UniProt:Q8N720 ZNF655	1	ZNF655 [nucleoplasm] (R-HSA-2127575)	0.556	3
UniProt:Q13422-7 IKZF1			0.556	3
UniProt:Q96N21 AP4AT			0.556	3
UniProt:O95678 KRT75	1	KRT75 [cytosol] (R-HSA-6809652)	0.556	3
UniProt:P32502	1	GCD7 [cytosol] (R-SCE-72519)	0.556	3
UniProt:P36406 TRI23			0.556	3
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:Q8N684-3 CPSF7			0.556	3
UniProt:Q86YD7 F90A1			0.556	3
UniProt:Q96BU1 S1PBP			0.556	3
UniProt:Q03262	5	PRM15 [ficolin-1-rich granule lumen] (R-SCE-6801476) PRM15 [extracellular region] (R-SCE-6806446) PRM15 [secretory granule lumen] (R-SCE-6801502) PRM15 [cytosol] (R-SCE-453136) PRM15 [cytosol] (R-SCE-8955671)	0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:Q8WXF1-2 PSPC1			0.556	3
UniProt:Q99932-2 SPAG8			0.556	3
UniProt:Q5RL73 RBM48			0.553	2
UniProt:P05386 RPLP1	1	RPLP1 [cytosol] (R-HSA-72398)	0.553	2
UniProt:Q9P2H0 CE126			0.553	2
UniProt:O75533 SF3B1	1	SF3B1 [nucleoplasm] (R-HSA-71968)	0.547	3
UniProt:Q86X55 CARM1	1	CARM1 [nucleoplasm] (R-HSA-400139)	0.508	2
UniProt:P61978 HNRNPK	2	HNRNPK [nucleoplasm] (R-HSA-71945) polySUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532)	0.462	2

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