Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
FUS [nucleoplasm]
Stable Identifier
R-HSA-72040
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
FUS - RNA binding protein/TLS, RNA-binding protein FUS, Oncogene FUS, Oncogene TLS, Translocated in liposarcoma protein, POMp75, 75 kDa DNA-pairing protein
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
mRNA Splicing (Homo sapiens)
mRNA Splicing - Major Pathway (Homo sapiens)
Cleavage at the 3'-Splice Site and Exon Ligation (Homo sapiens)
intron-containing complex [nucleoplasm] (Homo sapiens)
FUS [nucleoplasm] (Homo sapiens)
pre-EJC:Spliceosomal C:pre-mRNP:CBC [nucleoplasm] (Homo sapiens)
FUS [nucleoplasm] (Homo sapiens)
Formation of Exon Junction Complex (Homo sapiens)
Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
FUS [nucleoplasm] (Homo sapiens)
pre-EJC:Spliceosomal C:pre-mRNP:CBC [nucleoplasm] (Homo sapiens)
FUS [nucleoplasm] (Homo sapiens)
Formation of an intermediate Spliceosomal C (Bact) complex (Homo sapiens)
Spliceosomal B Complex [nucleoplasm] (Homo sapiens)
FUS [nucleoplasm] (Homo sapiens)
Spliceosomal Intermediate C (Bact) Complex [nucleoplasm] (Homo sapiens)
FUS [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal A Complex (Homo sapiens)
Spliceosomal A Complex [nucleoplasm] (Homo sapiens)
FUS [nucleoplasm] (Homo sapiens)
Spliceosomal E Complex [nucleoplasm] (Homo sapiens)
FUS [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal B Complex (Homo sapiens)
Spliceosomal A Complex [nucleoplasm] (Homo sapiens)
FUS [nucleoplasm] (Homo sapiens)
Spliceosomal B Complex [nucleoplasm] (Homo sapiens)
FUS [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal E complex (Homo sapiens)
FUS [nucleoplasm] (Homo sapiens)
Spliceosomal E Complex [nucleoplasm] (Homo sapiens)
FUS [nucleoplasm] (Homo sapiens)
Formation of the active Spliceosomal C (B*) complex (Homo sapiens)
Spliceosomal Active C (B*) Complex [nucleoplasm] (Homo sapiens)
FUS [nucleoplasm] (Homo sapiens)
Spliceosomal Intermediate C (Bact) Complex [nucleoplasm] (Homo sapiens)
FUS [nucleoplasm] (Homo sapiens)
Lariat Formation and 5'-Splice Site Cleavage (Homo sapiens)
Spliceosomal Active C (B*) Complex [nucleoplasm] (Homo sapiens)
FUS [nucleoplasm] (Homo sapiens)
Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
FUS [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35637 FUS
Gene Names
FUS, TLS
Chain
chain:1-526
Reference Genes
BioGPS Gene:2521 FUS
COSMIC (genes):FUS FUS
CTD Gene:2521 FUS
dbSNP Gene:2521 FUS
ENSEMBL:ENSG00000089280 FUS
HGNC:4010 FUS
KEGG Gene (Homo sapiens):2521 FUS
Monarch:2521 FUS
NCBI Gene:2521 FUS
OMIM:137070 FUS
UCSC:P35637 FUS
Reference Transcript
RefSeq:NM_004960.3 FUS
RefSeq:NM_001170634.1 FUS
Other Identifiers
0001090348
11745190_a_at
1565717_s_at
16818207
200959_3p_at
200959_at
217370_3p_x_at
217370_x_at
2521
3656910
3656912
3656913
3656916
3656917
3656918
3656919
3656920
3656924
3656926
3656928
3656932
3656933
3656936
3656940
3656941
3656942
3656944
3656945
3656946
3656947
39180_at
7995069
A_23_P106887
GE58786
GE85981
GO:0000398
GO:0003674
GO:0003676
GO:0003677
GO:0003682
GO:0003712
GO:0003713
GO:0003723
GO:0003729
GO:0003730
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005844
GO:0006259
GO:0006355
GO:0006357
GO:0006397
GO:0006950
GO:0008092
GO:0008134
GO:0008150
GO:0008380
GO:0009056
GO:0009058
GO:0010467
GO:0022607
GO:0030331
GO:0030425
GO:0031489
GO:0032991
GO:0034641
GO:0034655
GO:0035255
GO:0042802
GO:0043025
GO:0043167
GO:0043197
GO:0043204
GO:0043226
GO:0043484
GO:0044327
GO:0046872
GO:0046965
GO:0046966
GO:0048255
GO:0048471
GO:0051260
GO:0065003
GO:0071277
GO:1903508
GO:1905168
Hs.99969.2.S1_3p_a_at
Hs.99969.2.S1_3p_s_at
Hs.99969.2.S1_3p_x_at
Hs.99969.3.S1_3p_at
Hs2.392171.1.S1_3p_s_at
ILMN_2306066
PH_hs_0022279
PH_hs_0031515
TC16000372.hg
TC16001494.hg
X71428_at
g4826733_3p_at
g4826733_3p_s_at
g4826733_3p_x_at
Participant Of
input
Formation of the Spliceosomal E complex
hasComponent
intron-containing complex [nucleoplasm]
pre-EJC:Spliceosomal C:pre-mRNP:CBC [nucleoplasm]
Spliceosomal A Complex [nucleoplasm]
Spliceosomal Active C (B*) Complex [nucleoplasm]
Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex [nucleoplasm]
Spliceosomal B Complex [nucleoplasm]
Spliceosomal E Complex [nucleoplasm]
Spliceosomal Intermediate C (Bact) Complex [nucleoplasm]
Inferred To
caz [nucleoplasm] (Drosophila melanogaster)
fust-1 [nucleoplasm] (Caenorhabditis elegans)
Fus [nucleoplasm] (Mus musculus)
Fus [nucleoplasm] (Rattus norvegicus)
fus [nucleoplasm] (Danio rerio)
fus [nucleoplasm] (Xenopus tropicalis)
Ghost homologue of FUS [nucleoplasm] (Dictyostelium discoideum)
FUS [nucleoplasm] (Canis familiaris)
FUS [nucleoplasm] (Gallus gallus)
FUS [nucleoplasm] (Sus scrofa)
Cross References
RefSeq
NP_004951.1
,
NP_001164105.1
OpenTargets
ENSG00000089280
HPA
ENSG00000089280-FUS
GeneCards
P35637
Ensembl
ENSP00000254108
,
ENST00000380244
,
ENSG00000089280
,
ENST00000254108
,
ENSP00000369594
PRO
P35637
Orphanet
17369
PDB
6KJ1
,
4FDD
,
5XSG
,
6BXV
,
5YVG
,
2LCW
,
2LA6
,
5W3N
,
6BZP
,
6G99
,
5YVH
,
6KJ4
,
6KJ2
,
6GBM
,
4FQ3
,
5YVI
,
5XRR
,
6KJ3
,
6BWZ
Interactors (43)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35637 FUS
1
FUS [nucleoplasm]
(R-HSA-72040)
0.829
9
UniProt:Q13148 TADBP
0.683
8
UniProt:O60739 EIF1B
0.675
4
UniProt:O75815 BCAR3
0.675
4
UniProt:O15479 MAGB2
0.675
4
UniProt:Q92804 TAF15
1
TAF15 [nucleoplasm]
(R-HSA-9020680)
0.659
7
UniProt:Q99873 PRMT1
2
PRMT1 [cytosol]
(R-HSA-9632173)
PRMT1 [nucleoplasm]
(R-HSA-3215140)
0.657
5
UniProt:P43243 MATR3
0.656
7
UniProt:Q15424 SAFB
3
SUMO2,3-K231,K294-SAFB [nucleoplasm]
(R-HSA-4085357)
SAFB [nucleoplasm]
(R-HSA-4085379)
SUMO1-K231,K294-SAFB [nucleoplasm]
(R-HSA-4085343)
0.644
7
UniProt:P45481 Crebbp
4
Crebbp [nucleoplasm]
(R-MMU-556795)
Crebbp [nucleoplasm]
(R-MMU-193545)
Foxo4-S-S-Crebbp [nucleoplasm]
(R-MMU-9617719)
Sumo1-K999,K1034,K1057-Crebbp [nucleoplasm]
(R-MMU-3927936)
0.602
4
UniProt:Q09472 EP300
5
Foxo4-S-S-EP300 [nucleoplasm]
(R-HSA-9617720)
SUMO1-K1020,1024-EP300 [nucleoplasm]
(R-HSA-3899306)
FOXO4-S-S-EP300 [nucleoplasm]
(R-HSA-9617691)
p-S,T-EP300 [nucleoplasm]
(R-HSA-8878072)
EP300 [nucleoplasm]
(R-HSA-381325)
0.591
4
UniProt:Q99873-3 PRMT1
0.571
3
UniProt:Q92973-2 TNPO1
0.558
2
UniProt:Q8NHS9 SPT22
0.556
3
UniProt:Q04206-3 RELA
0.556
3
UniProt:P18206-2 VCL
0.556
3
UniProt:Q9BYU1 PBX4
0.556
3
IntAct:EBI-25831191 CCSB
0.556
3
UniProt:P48730-2 CSNK1D
0.556
3
UniProt:Q96FW1 OTUB1
2
OTUB1 [nucleoplasm]
(R-HSA-6783242)
OTUB1 [cytosol]
(R-HSA-933411)
0.556
3
UniProt:Q9BUL9 RPP25
1
RPP25 [nucleoplasm]
(R-HSA-5696782)
0.556
3
UniProt:Q13191 CBLB
1
CBLB [cytosol]
(R-HSA-976009)
0.556
3
UniProt:Q9UKA9-2 PTBP2
0.556
3
UniProt:P60896 SEM1
2
SHFM1 [cytosol]
(R-HSA-8866674)
SHFM1 [nucleoplasm]
(R-HSA-8866665)
0.556
3
UniProt:P49841-2 GSK3B
0.556
3
UniProt:P19793 RXRA
4
p-S21-RXRA [nucleoplasm]
(R-HSA-5334811)
RXRA [cytosol]
(R-HSA-9619757)
SUMO1-K108-RXRA [nucleoplasm]
(R-HSA-4341130)
RXRA [nucleoplasm]
(R-HSA-381319)
0.556
3
UniProt:Q9UKM9 RALY
0.556
5
UniProt:P46379-2 BAG6
0.556
3
UniProt:Q8N488 RYBP
1
RYBP [nucleoplasm]
(R-HSA-8937975)
0.556
3
UniProt:Q05586 GRIN1
3
GRIN1 [endoplasmic reticulum membrane]
(R-HSA-9609763)
GRIN1 [transport vesicle membrane]
(R-HSA-9610565)
GRIN1 [plasma membrane]
(R-HSA-419564)
0.556
3
UniProt:Q15149 PLEC
3
PLEC(1-2395) [cytosol]
(R-HSA-350638)
PLEC(2396-4684) [cytosol]
(R-HSA-350618)
PLEC [cytosol]
(R-HSA-201575)
0.556
4
UniProt:P38159 RBMX
1
RBMX [nucleoplasm]
(R-HSA-71939)
0.547
5
UniProt:Q01844 EWS
0.547
5
UniProt:P97801
2
Smn1 [cytosol]
(R-MMU-191839)
Smn1 [nucleoplasm]
(R-MMU-191892)
0.537
5
UniProt:Q92993 KAT5
1
KAT5 [nucleoplasm]
(R-HSA-3321979)
0.524
2
UniProt:Q9NRR4 DROSHA
1
DROSHA [nucleoplasm]
(R-HSA-1482510)
0.524
2
IntAct:EBI-6932561 FUS
0.512
4
UniProt:Q08211 DHX9
2
DHX9 [nucleoplasm]
(R-HSA-53517)
DHX9 [cytosol]
(R-HSA-847700)
0.512
8
UniProt:Q6RFH8 DUX4C
0.463
2
UniProt:Q9UBX2 DUX4
0.463
2
UniProt:P03372 ESR1
8
SUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.462
2
UniProt:Q12905 ILF2
4
ILF2 [specific granule lumen]
(R-HSA-6799611)
ILF2 [ficolin-1-rich granule lumen]
(R-HSA-6801001)
ILF2 [extracellular region]
(R-HSA-6799684)
ILF2 [tertiary granule lumen]
(R-HSA-6800995)
0.462
7
UniProt:P09651 HNRNPA1
1
HNRNPA1 [nucleoplasm]
(R-HSA-71927)
0.462
3
© 2021
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text