Reactome | FUS [nucleoplasm]

FUS [nucleoplasm]

Stable Identifier

R-HSA-72040

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

FUS - RNA binding protein/TLS, RNA-binding protein FUS, Oncogene FUS, Oncogene TLS, Translocated in liposarcoma protein, POMp75, 75 kDa DNA-pairing protein

Locations in the PathwayBrowser for interactor IntAct:EBI-25831191

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External Reference Information

External Reference

UniProt:P35637 FUS

Gene Names

FUS, TLS

Chain

chain:1-526

Reference Genes

BioGPS Gene:2521 FUS

COSMIC (genes):FUS FUS

CTD Gene:2521 FUS

dbSNP Gene:2521 FUS

ENSEMBL:ENSG00000089280 FUS

HGNC:4010 FUS

KEGG Gene (Homo sapiens):2521 FUS

Monarch:2521 FUS

NCBI Gene:2521 FUS

OMIM:137070 FUS

UCSC:P35637 FUS

Reference Transcript

Other Identifiers

0001090348

11745190_a_at

1565717_s_at

16818207

200959_3p_at

200959_at

217370_3p_x_at

217370_x_at

2521

3656910

3656912

3656913

3656916

3656917

3656918

3656919

3656920

3656924

3656926

3656928

3656932

3656933

3656936

3656940

3656941

3656942

3656944

3656945

3656946

3656947

39180_at

7995069

A_23_P106887

GE58786

GE85981

GO:0000398

GO:0003674

GO:0003676

GO:0003677

GO:0003682

GO:0003712

GO:0003713

GO:0003723

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0006259

GO:0006355

GO:0006357

GO:0006397

GO:0006950

GO:0008150

GO:0008380

GO:0009056

GO:0009058

GO:0022607

GO:0034641

GO:0034655

GO:0042802

GO:0043167

GO:0043226

GO:0043484

GO:0045893

GO:0046872

GO:0048255

GO:0051260

GO:0065003

GO:1905168

HMNXSV003036649

Hs.99969.2.S1_3p_a_at

Hs.99969.2.S1_3p_s_at

Hs.99969.2.S1_3p_x_at

Hs.99969.3.S1_3p_at

Hs2.392171.1.S1_3p_s_at

ILMN_2306066

PH_hs_0022279

PH_hs_0031515

TC16000372.hg

TC16001494.hg

X71428_at

g4826733_3p_at

g4826733_3p_s_at

g4826733_3p_x_at

Participates

as an input of

Formation of the Spliceosomal E complex (Homo sapiens)

as a component of

Inferred To

caz [nucleoplasm] (Drosophila melanogaster)

fust-1 [nucleoplasm] (Caenorhabditis elegans)

Fus [nucleoplasm] (Mus musculus)

Fus [nucleoplasm] (Rattus norvegicus)

fus [nucleoplasm] (Danio rerio)

Ghost homologue of FUS [nucleoplasm] (Dictyostelium discoideum)

FUS [nucleoplasm] (Canis familiaris)

FUS [nucleoplasm] (Gallus gallus)

FUS [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_004951.1, NP_001164105.1

OpenTargets

ENSG00000089280

GeneCards

P35637

HPA

ENSG00000089280-FUS

Ensembl

ENSP00000369594, ENST00000254108, ENSP00000254108, ENST00000380244, ENSG00000089280

PRO

P35637

Orphanet

17369

PDB

6GBM, 6BXV, 6SNJ, 6KJ3, 5YVI, 2LCW, 5W3N, 6BZP, 6BWZ, 6G99, 5YVH, 6KJ2, 2LA6, 4FQ3, 5XRR, 5YVG, 6KJ1, 6XFM, 4FDD, 6KJ4, 5XSG

Interactors (41)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35637 FUS	1	FUS [nucleoplasm] (R-HSA-72040)	0.829	9
UniProt:Q13148 TADBP			0.683	8
UniProt:O60739 EIF1B			0.675	4
UniProt:O75815 BCAR3			0.675	4
UniProt:O15479 MAGB2			0.675	4
UniProt:Q92804 TAF15	1	TAF15 [nucleoplasm] (R-HSA-9020680)	0.659	7
UniProt:Q99873 PRMT1	2	PRMT1 [cytosol] (R-HSA-9632173) PRMT1 [nucleoplasm] (R-HSA-3215140)	0.657	5
UniProt:P43243 MATR3			0.656	7
UniProt:Q15424 SAFB	3	SUMO2,3-K231,K294-SAFB [nucleoplasm] (R-HSA-4085357) SAFB [nucleoplasm] (R-HSA-4085379) SUMO1-K231,K294-SAFB [nucleoplasm] (R-HSA-4085343)	0.644	7
UniProt:P45481 Crebbp	4	Crebbp [nucleoplasm] (R-MMU-556795) Crebbp [nucleoplasm] (R-MMU-193545) Foxo4-S-S-Crebbp [nucleoplasm] (R-MMU-9617719) Sumo1-K999,K1034,K1057-Crebbp [nucleoplasm] (R-MMU-3927936)	0.602	4
UniProt:Q09472 EP300	5	Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) SUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) EP300 [nucleoplasm] (R-HSA-381325)	0.591	4
UniProt:Q99873-3 PRMT1			0.571	3
UniProt:Q92973-2 TNPO1			0.558	2
UniProt:Q8NHS9 SPT22			0.556	3
UniProt:Q04206-3 RELA			0.556	3
UniProt:P18206-2 VCL			0.556	3
UniProt:Q9BYU1 PBX4			0.556	3
IntAct:EBI-25831191 CCSB			0.556	3
UniProt:P48730-2 CSNK1D			0.556	3
UniProt:Q96FW1 OTUB1	2	OTUB1 [nucleoplasm] (R-HSA-6783242) OTUB1 [cytosol] (R-HSA-933411)	0.556	3
UniProt:Q9BUL9 RPP25	1	RPP25 [nucleoplasm] (R-HSA-5696782)	0.556	3
UniProt:Q13191 CBLB	1	CBLB [cytosol] (R-HSA-976009)	0.556	3
UniProt:Q9UKA9-2 PTBP2			0.556	3
UniProt:P60896 SEM1	2	SHFM1 [cytosol] (R-HSA-8866674) SHFM1 [nucleoplasm] (R-HSA-8866665)	0.556	3
UniProt:P49841-2 GSK3B			0.556	3
UniProt:Q05586 GRIN1	3	GRIN1 [endoplasmic reticulum membrane] (R-HSA-9609763) GRIN1 [transport vesicle membrane] (R-HSA-9610565) GRIN1 [plasma membrane] (R-HSA-419564)	0.556	3
UniProt:P19793 RXRA	4	p-S21-RXRA [nucleoplasm] (R-HSA-5334811) RXRA [cytosol] (R-HSA-9619757) SUMO1-K108-RXRA [nucleoplasm] (R-HSA-4341130) RXRA [nucleoplasm] (R-HSA-381319)	0.556	3
UniProt:P46379-2 BAG6			0.556	3
UniProt:Q8N488 RYBP	1	RYBP [nucleoplasm] (R-HSA-8937975)	0.556	3
UniProt:Q01844 EWS			0.547	5
UniProt:P38159 RBMX	2	RBMX [cytosol] (R-HSA-9715135) RBMX [nucleoplasm] (R-HSA-71939)	0.547	5
UniProt:P97801	2	Smn1 [cytosol] (R-MMU-191839) Smn1 [nucleoplasm] (R-MMU-191892)	0.537	5
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.524	2
UniProt:Q9NRR4 DROSHA	1	DROSHA [nucleoplasm] (R-HSA-1482510)	0.524	2
UniProt:Q9UKM9 RALY			0.518	5
UniProt:Q15149 PLEC	3	PLEC(1-2395) [cytosol] (R-HSA-350638) PLEC(2396-4684) [cytosol] (R-HSA-350618) PLEC [cytosol] (R-HSA-201575)	0.518	4
UniProt:Q08211 DHX9	2	DHX9 [nucleoplasm] (R-HSA-53517) DHX9 [cytosol] (R-HSA-847700)	0.512	8
IntAct:EBI-6932561 FUS			0.512	4
UniProt:P09651 HNRNPA1	1	HNRNPA1 [nucleoplasm] (R-HSA-71927)	0.462	3
UniProt:P03372 ESR1	8	SUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2
UniProt:Q12905 ILF2	4	ILF2 [specific granule lumen] (R-HSA-6799611) ILF2 [tertiary granule lumen] (R-HSA-6800995) ILF2 [extracellular region] (R-HSA-6799684) ILF2 [ficolin-1-rich granule lumen] (R-HSA-6801001)	0.462	7

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