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RNGTT [nucleoplasm]
Stable Identifier
R-HSA-72081
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
mRNA capping enzyme, (HCE) (HCAP1) (Includes: Polynucleotide 5'- triphosphatase (EC 3.1.3.33) (mRNA 5'-triphosphatase) (TPase); mRNA guanylyltransferase (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase)), HCE, HCAP1, Polynucleotide 5'- triphosphatase , mRNA 5'-triphosphatase, TPase, mRNA guanylyltransferase , GTP--RNA guanylyltransferase, GTase
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Late Phase of HIV Life Cycle (Homo sapiens)
Transcription of the HIV genome (Homo sapiens)
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection (Homo sapiens)
Activation of GT (Homo sapiens)
RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Homo sapiens)
RNGTT [nucleoplasm] (Homo sapiens)
RNA Pol II with phosphorylated CTD: CE complex with activated GT [nucleoplasm] (Homo sapiens)
RNGTT [nucleoplasm] (Homo sapiens)
RNA Polymerase II CTD (phosphorylated) binds to CE (Homo sapiens)
RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Homo sapiens)
RNGTT [nucleoplasm] (Homo sapiens)
RNGTT [nucleoplasm] (Homo sapiens)
SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Homo sapiens)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Homo sapiens)
RNGTT [nucleoplasm] (Homo sapiens)
RNA Pol II with phosphorylated CTD: CE complex with activated GT [nucleoplasm] (Homo sapiens)
RNGTT [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA Pol II CTD phosphorylation and interaction with CE (Homo sapiens)
Activation of GT (Homo sapiens)
RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Homo sapiens)
RNGTT [nucleoplasm] (Homo sapiens)
RNA Pol II with phosphorylated CTD: CE complex with activated GT [nucleoplasm] (Homo sapiens)
RNGTT [nucleoplasm] (Homo sapiens)
RNA Polymerase II CTD (phosphorylated) binds to CE (Homo sapiens)
RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Homo sapiens)
RNGTT [nucleoplasm] (Homo sapiens)
RNGTT [nucleoplasm] (Homo sapiens)
SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Homo sapiens)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Homo sapiens)
RNGTT [nucleoplasm] (Homo sapiens)
RNA Pol II with phosphorylated CTD: CE complex with activated GT [nucleoplasm] (Homo sapiens)
RNGTT [nucleoplasm] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
mRNA Capping (Homo sapiens)
Activation of GT (Homo sapiens)
RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Homo sapiens)
RNGTT [nucleoplasm] (Homo sapiens)
RNA Pol II with phosphorylated CTD: CE complex with activated GT [nucleoplasm] (Homo sapiens)
RNGTT [nucleoplasm] (Homo sapiens)
Capping complex formation (Homo sapiens)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Homo sapiens)
RNGTT [nucleoplasm] (Homo sapiens)
Capping complex (initial) [nucleoplasm] (Homo sapiens)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Homo sapiens)
RNGTT [nucleoplasm] (Homo sapiens)
Dissociation of transcript with 5'-GMP from GT (Homo sapiens)
Capping complex (GpppN..) [nucleoplasm] (Homo sapiens)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Homo sapiens)
RNGTT [nucleoplasm] (Homo sapiens)
Capping complex (with freed 5'- GMP) [nucleoplasm] (Homo sapiens)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Homo sapiens)
RNGTT [nucleoplasm] (Homo sapiens)
Formation of the CE:GMP intermediate complex (Homo sapiens)
Capping complex (intermediate) [nucleoplasm] (Homo sapiens)
Covalent CE:GMP intermediate complex [nucleoplasm] (Homo sapiens)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Homo sapiens)
RNGTT [nucleoplasm] (Homo sapiens)
Capping complex (hydrolyzed) [nucleoplasm] (Homo sapiens)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Homo sapiens)
RNGTT [nucleoplasm] (Homo sapiens)
Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Homo sapiens)
Capping complex (hydrolyzed) [nucleoplasm] (Homo sapiens)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Homo sapiens)
RNGTT [nucleoplasm] (Homo sapiens)
Capping complex (initial) [nucleoplasm] (Homo sapiens)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Homo sapiens)
RNGTT [nucleoplasm] (Homo sapiens)
RNGTT [nucleoplasm] (Homo sapiens)
Methylation of GMP-cap by RNA Methyltransferase (Homo sapiens)
Capping complex (with freed 5'- GMP) [nucleoplasm] (Homo sapiens)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Homo sapiens)
RNGTT [nucleoplasm] (Homo sapiens)
mRNA capping factors [nucleoplasm] (Homo sapiens)
RNGTT [nucleoplasm] (Homo sapiens)
RNA Polymerase II CTD (phosphorylated) binds to CE (Homo sapiens)
RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Homo sapiens)
RNGTT [nucleoplasm] (Homo sapiens)
RNGTT [nucleoplasm] (Homo sapiens)
SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Homo sapiens)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Homo sapiens)
RNGTT [nucleoplasm] (Homo sapiens)
RNA Pol II with phosphorylated CTD: CE complex with activated GT [nucleoplasm] (Homo sapiens)
RNGTT [nucleoplasm] (Homo sapiens)
Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Homo sapiens)
Capping complex (intermediate) [nucleoplasm] (Homo sapiens)
Covalent CE:GMP intermediate complex [nucleoplasm] (Homo sapiens)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Homo sapiens)
RNGTT [nucleoplasm] (Homo sapiens)
Capping complex (GpppN..) [nucleoplasm] (Homo sapiens)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Homo sapiens)
RNGTT [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O60942 RNGTT
Gene Names
RNGTT, CAP1A
Chain
chain:1-597
Reference Genes
BioGPS Gene:8732 RNGTT
COSMIC (genes):RNGTT RNGTT
CTD Gene:8732 RNGTT
dbSNP Gene:8732 RNGTT
ENSEMBL:ENSG00000111880 RNGTT
HGNC:10073 RNGTT
KEGG:hsa:8732 RNGTT
Monarch:8732 RNGTT
NCBI Gene:8732 RNGTT
OMIM:603512 RNGTT
UCSC:O60942 RNGTT
Reference Transcript
RefSeq:NM_001286428.1 RNGTT
RefSeq:NM_003800.4 RNGTT
RefSeq:NM_001286426.1 RNGTT
Other Identifiers
11721328_a_at
11721329_a_at
11721330_s_at
11721331_x_at
11747806_a_at
11747807_x_at
11749551_a_at
11749727_x_at
11758232_s_at
11761123_at
11761124_x_at
17021521
204207_PM_s_at
204207_s_at
204208_PM_at
204208_at
211387_PM_x_at
211387_x_at
211849_PM_s_at
211849_s_at
2963961
2963962
2963963
2963964
2963965
2963966
2963967
2963968
2963975
2963976
2963977
2963989
2963992
2963997
2963998
2963999
2964000
2964002
2964003
2964004
2964005
2964006
2964007
2964008
2964011
2964012
2964014
2964016
2964017
2964018
2964019
2964029
35202_at
8128052
8732
A_23_P325075
A_33_P3212037
GE54199
GO:0003824
GO:0004484
GO:0004651
GO:0004721
GO:0005515
GO:0005524
GO:0005525
GO:0005634
GO:0005654
GO:0006139
GO:0006370
GO:0006396
GO:0006470
GO:0008192
GO:0016071
GO:0016311
GO:0016740
GO:0016779
GO:0016787
GO:0043226
GO:0050355
GO:0140096
GO:0140098
GO:0140818
HMNXSV003004173
HMNXSV003033550
ILMN_1734198
PH_hs_0002428
TC06001934.hg
g2979495_3p_a_at
g2979497_3p_at
g3097309_3p_a_at
g4506562_3p_at
Participates
as an input of
RNA Polymerase II CTD (phosphorylated) binds to CE (Homo sapiens)
RNA Polymerase II CTD (phosphorylated) binds to CE (Homo sapiens)
as a component of
RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Homo sapiens)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Homo sapiens)
RNA Pol II with phosphorylated CTD: CE complex with activated GT [nucleoplasm] (Homo sapiens)
RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Homo sapiens)
RNA Pol II with phosphorylated CTD: CE complex with activated GT [nucleoplasm] (Homo sapiens)
mRNA capping factors [nucleoplasm] (Homo sapiens)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Homo sapiens)
Inferred To
Ghost homologue of RNGTT [nucleoplasm]
(Plasmodium falciparum)
RNGTT [nucleoplasm]
(Bos taurus)
RNGTT [nucleoplasm]
(Caenorhabditis elegans)
RNGTT [nucleoplasm]
(Canis familiaris)
RNGTT [nucleoplasm]
(Danio rerio)
RNGTT [nucleoplasm]
(Dictyostelium discoideum)
RNGTT [nucleoplasm]
(Drosophila melanogaster)
RNGTT [nucleoplasm]
(Gallus gallus)
RNGTT [nucleoplasm]
(Mus musculus)
RNGTT [nucleoplasm]
(Sus scrofa)
RNGTT [nucleoplasm]
(Xenopus tropicalis)
Rngtt [nucleoplasm]
(Rattus norvegicus)
ceg1 [nucleoplasm]
(Schizosaccharomyces pombe)
CEG1 [nucleoplasm]
(Saccharomyces cerevisiae)
Cross References
RefSeq
NP_003791.3
,
NP_001273357.1
,
NP_001273355.1
ENSEMBL
ENSP00000358497
,
ENSP00000358487
,
ENSP00000442609
,
ENST00000369485
,
ENST00000369475
,
ENST00000538899
OpenTargets
ENSG00000111880
IntEnz
3.6.1.74
HPA
ENSG00000111880-RNGTT
PRO
O60942
Pharos - Targets
O60942
GlyGen
O60942
HMDB Protein
HMDBP01080
PDB
8P4B
,
8P4E
,
8W8E
,
2C46
,
8W8F
,
8P4D
,
3S24
,
8P4C
,
8P4A
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q92624 APBP2
0.556
3
UniProt:O15514 POLR2D
1
POLR2D [nucleoplasm]
(R-HSA-63508)
0.527
2
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