Reactome: A Curated Pathway Database

Formation of the Spliceosomal A Complex

Stable Identifier
R-HSA-72124
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The A complex is the first ATP-dependent complex in spliceosome assembly. U2AF recruits the U2 snRNP to bind to the branch site in the E complex in an ATP-dependent fashion, to form the A complex. The U2 snRNA base-pairs with the branch site, causing the branch-site adenosine to bulge out, which later positions it for nucleophilic attack at the 5' splice site. The A complex serves as a substrate for formation of the B complex.

Literature References
Participants
Participant Of
Orthologous Events