Formation of the active Spliceosomal C (B*) complex

Stable Identifier
R-HSA-72139
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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The active C complex is formed due to a conformational change in the intermediate C complex. After formation of the active C complex, the splicing reactions occur very rapidly.

Literature References
PubMed ID Title Journal Year
11991638 Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

Jurica, MS, Licklider, LJ, Gygi, SR, Grigorieff, N, Moore, MJ

RNA 2002
23345524 Rearrangements within human spliceosomes captured after exon ligation

Ilagan, JO, Chalkley, RJ, Burlingame, AL, Jurica, MS

RNA 2013
12176931 Large-scale proteomic analysis of the human spliceosome.

Rappsilber, J, Ryder, U, Lamond, AI, Mann, M

Genome Res 2002
20423332 Contribution of DEAH-box protein DHX16 in human pre-mRNA splicing

Gencheva, M, Kato, M, Newo, AN, Lin, RJ

Biochem. J. 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ATPase activity of Spliceosomal Intermediate C (Bact) Complex [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Created