Formation of the active Spliceosomal C (B*) complex

Stable Identifier
R-HSA-72139
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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Formation of the active Spliceosomal C (B*) complex
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The active C complex is formed due to a conformational change in the intermediate C complex. After formation of the active C complex, the splicing reactions occur very rapidly.

Literature References
PubMed ID Title Journal Year
11991638 Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

Jurica, MS, Licklider, LJ, Gygi, SR, Grigorieff, N, Moore, MJ

RNA 2002
23345524 Rearrangements within human spliceosomes captured after exon ligation

Ilagan, JO, Chalkley, RJ, Burlingame, AL, Jurica, MS

RNA 2013
12176931 Large-scale proteomic analysis of the human spliceosome.

Rappsilber, J, Ryder, U, Lamond, AI, Mann, M

Genome Res 2002
20423332 Contribution of DEAH-box protein DHX16 in human pre-mRNA splicing

Gencheva, M, Kato, M, Newo, AN, Lin, RJ

Biochem. J. 2010
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
ATPase activity of Spliceosomal Intermediate C (Bact) Complex [nucleoplasm]
Physical Entity
Spliceosomal Intermediate C (Bact) Complex [nucleoplasm]
Activity
ATPase activity (0016887)
Orthologous Events
Formation of the active Spliceosomal C (B*) complex (Caenorhabditis elegans)
Formation of the active Spliceosomal C (B*) complex (Canis familiaris)
Formation of the active Spliceosomal C (B*) complex (Danio rerio)
Formation of the active Spliceosomal C (B*) complex (Dictyostelium discoideum)
Formation of the active Spliceosomal C (B*) complex (Drosophila melanogaster)
Formation of the active Spliceosomal C (B*) complex (Gallus gallus)
Formation of the active Spliceosomal C (B*) complex (Mus musculus)
Formation of the active Spliceosomal C (B*) complex (Rattus norvegicus)
Formation of the active Spliceosomal C (B*) complex (Schizosaccharomyces pombe)
Formation of the active Spliceosomal C (B*) complex (Sus scrofa)
Formation of the active Spliceosomal C (B*) complex (Xenopus tropicalis)
Created
Krainer, AR  (2003-06-05)