Reactome | Formation of the active Spliceosomal C (B*) complex

Formation of the active Spliceosomal C (B*) complex

Stable Identifier

R-HSA-72139

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Formation of the active Spliceosomal C (B*) complex

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The active C complex is formed due to a conformational change in the intermediate C complex. After formation of the active C complex, the splicing reactions occur very rapidly.

Literature References

PubMed ID	Title	Journal	Year
11991638	Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. Jurica, MS, Licklider, LJ, Gygi, SR, Grigorieff, N, Moore, MJ	RNA	2002
23345524	Rearrangements within human spliceosomes captured after exon ligation Ilagan, JO, Chalkley, RJ, Burlingame, AL, Jurica, MS	RNA	2013
12176931	Large-scale proteomic analysis of the human spliceosome. Rappsilber, J, Ryder, U, Lamond, AI, Mann, M	Genome Res	2002
20423332	Contribution of DEAH-box protein DHX16 in human pre-mRNA splicing Gencheva, M, Kato, M, Newo, AN, Lin, RJ	Biochem. J.	2010