Cleavage at the 3'-Splice Site and Exon Ligation

Stable Identifier
R-HSA-72160
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Second step of mRNA splicing
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Cleavage at the 3'-Splice Site and Exon Ligation
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The second step of the splicing reaction results in cleavage of the transcript at the 3'splice site, and results in ligation of the two exons and excision of the intron.

Literature References
PubMed ID Title Journal Year
15166247 Association of the breast cancer protein MLN51 with the exon junction complex via its speckle localizer and RNA binding module

Degot, S, Le Hir, H, Alpy, F, Kedinger, V, Stoll, I, Wendling, C, Séraphin, B, Rio, MC, Tomasetto, C

J. Biol. Chem. 2004
15024032 In vitro FRAP reveals the ATP-dependent nuclear mobilization of the exon junction complex protein SRm160

Wagner, S, Chiosea, S, Ivshina, M, Nickerson, JA

J. Cell Biol. 2004
19103666 Isolation and characterization of post-splicing lariat-intron complexes

Yoshimoto, R, Kataoka, N, Okawa, K, Ohno, M

Nucleic Acids Res. 2009
23345524 Rearrangements within human spliceosomes captured after exon ligation

Ilagan, JO, Chalkley, RJ, Burlingame, AL, Jurica, MS

RNA 2013
22419818 Perispeckles are major assembly sites for the exon junction core complex

Daguenet, E, Baguet, A, Degot, S, Schmidt, U, Alpy, F, Wendling, C, Spiegelhalter, C, Kessler, P, Rio, MC, Le Hir, H, Bertrand, E, Tomasetto, C

Mol. Biol. Cell 2012
Participants
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Participant Of
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Orthologous Events
Cleavage at the 3'-Splice Site and Exon Ligation (Canis familiaris)
Cleavage at the 3'-Splice Site and Exon Ligation (Mus musculus)
Created
Krainer, AR  (2003-06-05)