Reactome | Cleavage at the 3'-Splice Site and Exon Ligation

Cleavage at the 3'-Splice Site and Exon Ligation

Stable Identifier

R-HSA-72160

Type

Reaction [BlackBoxEvent]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Second step of mRNA splicing

Locations in the PathwayBrowser

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Summation

The second step of the splicing reaction results in cleavage of the transcript at the 3'splice site, and results in ligation of the two exons and excision of the intron.

Literature References

PubMed ID	Title	Journal	Year
15166247	Association of the breast cancer protein MLN51 with the exon junction complex via its speckle localizer and RNA binding module	J. Biol. Chem.	2004
15024032	In vitro FRAP reveals the ATP-dependent nuclear mobilization of the exon junction complex protein SRm160	J. Cell Biol.	2004
19103666	Isolation and characterization of post-splicing lariat-intron complexes	Nucleic Acids Res.	2009
23345524	Rearrangements within human spliceosomes captured after exon ligation	RNA	2013
22419818	Perispeckles are major assembly sites for the exon junction core complex	Mol. Biol. Cell	2012

Participants

Input

Output

Participant Of

hasEvent

mRNA Splicing - Major Pathway

Orthologous Events

Cleavage at the 3'-Splice Site and Exon Ligation (Danio rerio)

Cleavage at the 3'-Splice Site and Exon Ligation (Xenopus tropicalis)