Reactome | Cleavage at the 3'-Splice Site and Exon Ligation

Cleavage at the 3'-Splice Site and Exon Ligation

Stable Identifier

R-HSA-72160

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Second step of mRNA splicing

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Cleavage at the 3'-Splice Site and Exon Ligation

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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The second step of the splicing reaction results in cleavage of the transcript at the 3'splice site, and results in ligation of the two exons and excision of the intron.

Literature References

PubMed ID	Title	Journal	Year
15166247	Association of the breast cancer protein MLN51 with the exon junction complex via its speckle localizer and RNA binding module Degot, S, Le Hir, H, Alpy, F, Kedinger, V, Stoll, I, Wendling, C, Séraphin, B, Rio, MC, Tomasetto, C	J. Biol. Chem.	2004
15024032	In vitro FRAP reveals the ATP-dependent nuclear mobilization of the exon junction complex protein SRm160 Wagner, S, Chiosea, S, Ivshina, M, Nickerson, JA	J. Cell Biol.	2004
19103666	Isolation and characterization of post-splicing lariat-intron complexes Yoshimoto, R, Kataoka, N, Okawa, K, Ohno, M	Nucleic Acids Res.	2009
23345524	Rearrangements within human spliceosomes captured after exon ligation Ilagan, JO, Chalkley, RJ, Burlingame, AL, Jurica, MS	RNA	2013
22419818	Perispeckles are major assembly sites for the exon junction core complex Daguenet, E, Baguet, A, Degot, S, Schmidt, U, Alpy, F, Wendling, C, Spiegelhalter, C, Kessler, P, Rio, MC, Le Hir, H, Bertrand, E, Tomasetto, C	Mol. Biol. Cell	2012