11014198 |
The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans
Reed, R,
Luo, MJ,
Katahira, J,
Hurt, E,
Straesser, K,
Zhou, Z
|
Nature |
2000 |
20980672 |
Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis
Sander, B,
Will, CL,
Lührmann, R,
Anokhina, M,
Golas, MM,
Krasauskas, A,
Bessonov, S,
Stark, H,
Urlaub, H
|
RNA |
2010 |
10882114 |
Functional association of U2 snRNP with the ATP-independent spliceosomal complex E
Reed, R,
Das, R,
Zhou, Z
|
Mol Cell |
2000 |
12411573 |
Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome
Makarova, OV,
Will, CL,
Gentzel, M,
Lührmann, R,
Wilm, M,
Makarov, EM,
Urlaub, H
|
Science |
2002 |
29361316 |
Structure and Conformational Dynamics of the Human Spliceosomal Bact Complex
Komarov, I,
Lührmann, R,
Graf, B,
Dybkov, O,
Agafonov, DE,
Haselbach, D,
Stark, H,
Urlaub, H,
Kastner, B,
Hartmuth, K
|
Cell |
2018 |
18322460 |
Isolation of an active step I spliceosome and composition of its RNP core
Will, CL,
Lührmann, R,
Anokhina, M,
Bessonov, S,
Urlaub, H
|
Nature |
2008 |
30765414 |
Structural Insights into Nuclear pre-mRNA Splicing in Higher Eukaryotes
Will, CL,
Lührmann, R,
Stark, H,
Kastner, B
|
Cold Spring Harb Perspect Biol |
2019 |
32494006 |
Molecular architecture of the human 17S U2 snRNP
Bertram, K,
Will, CL,
Lührmann, R,
Dybkov, O,
Agafonov, DE,
Stark, H,
Urlaub, H,
Kastner, B,
Zhang, Z,
Hofele, R,
Hartmuth, K
|
Nature |
2020 |
29360106 |
Structure of the human activated spliceosome in three conformational states
Shi, Y,
Li, L,
Yan, C,
Zhang, X,
Lei, J,
Zhan, X
|
Cell Res |
2018 |
23345524 |
Rearrangements within human spliceosomes captured after exon ligation
Ilagan, JO,
Chalkley, RJ,
Jurica, MS,
Burlingame, AL
|
RNA |
2013 |
21536652 |
Semiquantitative proteomic analysis of the human spliceosome via a novel two-dimensional gel electrophoresis method
Will, CL,
Lührmann, R,
Deckert, J,
Odenwälder, P,
Agafonov, DE,
Bessonov, S,
Urlaub, H,
Wolf, E
|
Mol Cell Biol |
2011 |
14625303 |
A simple whole cell lysate system for in vitro splicing reveals a stepwise assembly of the exon-exon junction complex
Kataoka, N,
Dreyfuss, G
|
J Biol Chem |
2004 |
17095540 |
Protein composition of human mRNPs spliced in vitro and differential requirements for mRNP protein recruitment
Will, CL,
Lührmann, R,
Urlaub, H,
Merz, C
|
RNA |
2007 |
17332742 |
Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes
Sander, B,
Will, CL,
Lührmann, R,
Deckert, J,
Golas, MM,
Dube, P,
Stark, H,
Urlaub, H,
Behzadnia, N,
Kastner, B,
Hartmuth, K
|
EMBO J. |
2007 |
16809785 |
Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions
Will, CL,
Lührmann, R,
Deckert, J,
Boehringer, D,
Urlaub, H,
Stark, H,
Behzadnia, N,
Kastner, B,
Hartmuth, K
|
Mol. Cell. Biol. |
2006 |
26420826 |
Mammalian splicing factor SF1 interacts with SURP domains of U2 snRNP-associated proteins
Bagdiul, I,
Raabe, M,
Rain, JC,
Urlaub, H,
Raleff, F,
Krämer, A,
Crisci, A
|
Nucleic Acids Res. |
2015 |
23222130 |
Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA
Chang, X,
Shi, M,
Wu, G,
Chi, B,
Wang, L,
Tan, M,
Wang, Q,
Cheng, H
|
Nucleic Acids Res. |
2013 |
14713954 |
Prp5 bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA
Kameoka, S,
Xu, YZ,
Huang, T,
Query, CC,
Newnham, CM,
Konarska, MM
|
EMBO J |
2004 |
25555158 |
Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition
Kondo, Y,
van Roon, AM,
Nagai, K,
Oubridge, C
|
Elife |
2015 |
3757028 |
A compensatory base change in U1 snRNA suppresses a 5' splice site mutation
Zhuang, Y,
Weiner, AM
|
Cell |
1986 |
18593880 |
Distinct activities of the DExD/H-box splicing factor hUAP56 facilitate stepwise assembly of the spliceosome
Zhang, L,
Shen, J,
Zheng, X,
Shen, H,
Zhao, R,
Green, MR
|
Genes Dev |
2008 |
2558966 |
Mammalian pre-mRNA branch site selection by U2 snRNP involves base pairing
Manley, JL,
Wu, J
|
Genes Dev |
1989 |
30705154 |
A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation
Wilkinson, ME,
Fica, SM,
Nagai, K,
Newman, AJ,
Oubridge, C
|
Science |
2019 |
9016565 |
Association of U2 snRNP with the spliceosomal complex E
Bennett, M,
Hong, W,
Reed, R,
Feld Kramer, R,
Wang, C,
Xiao, Y
|
Nucleic Acids Res |
1997 |
9242493 |
U2AF65 recruits a novel human DEAD box protein required for the U2 snRNP-branchpoint interaction
Valcárcel, J,
Green, MR,
Fleckner, J,
Zhang, M
|
Genes Dev |
1997 |
22365833 |
Dynamic protein-protein interaction wiring of the human spliceosome
Pena, V,
Will, CL,
Lührmann, R,
Weimann, M,
Wowro, S,
Sourlis, C,
Stelzl, U,
Hegele, A,
Grossmann, A,
Kamburov, A
|
Mol. Cell |
2012 |
31409651 |
Structural and functional characterisation of human RNA helicase DHX8 provides insights into the mechanism of RNA-stimulated ADP release
Thomas, JC,
Workman, P,
Felisberto-Rodrigues, C,
Le Bihan, YV,
Burke, R,
McAndrew, C,
van Montfort, RLM
|
Biochem J |
2019 |
9524131 |
Human homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step II of pre-mRNA splicing
Reed, R,
Zhou, Z
|
EMBO J |
1998 |
24448447 |
Mass spectrometry-based relative quantification of proteins in precatalytic and catalytically active spliceosomes by metabolic labeling (SILAC), chemical labeling (iTRAQ), and label-free spectral count
Lührmann, R,
Deckert, J,
Schmidt, C,
Bessonov, S,
Urlaub, H,
Conrad, T,
Grønborg, M
|
RNA |
2014 |
24914973 |
Structural and functional analysis of the human spliceosomal DEAD-box helicase Prp28
Neumann, P,
Möhlmann, S,
Lührmann, R,
Schmitt, A,
Ficner, R,
Mathew, R
|
Acta Crystallogr D Biol Crystallogr |
2014 |
9539711 |
The human U5-200kD DEXH-box protein unwinds U4/U6 RNA duplices in vitro
Achsel, T,
Lührmann, R,
Laggerbauer, B
|
Proc Natl Acad Sci U S A |
1998 |
32717639 |
Cryo-EM snapshots of the human spliceosome reveal structural adaptions for splicing regulation
Fica, SM
|
Curr Opin Struct Biol |
2020 |
8608946 |
A human RNA helicase-like protein, HRH1, facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome
Ohno, M,
Shimura, Y
|
Genes Dev |
1996 |
9701291 |
The mammalian homologue of Prp16p is overexpressed in a cell line tolerant to Leflunomide, a new immunoregulatory drug effective against rheumatoid arthritis
Achsel, T,
Lührmann, R,
Ortlepp, D,
Kirschbaum, B,
Müllner, S,
Laggerbauer, B
|
RNA |
1998 |
11233976 |
The 100-kda U5 snRNP protein (hPrp28p) contacts the 5' splice site through its ATPase site
Sha, M,
Konarska, MM,
Gustafson, EH,
Ismaïli, N
|
RNA |
2001 |
29301961 |
Structure of a human catalytic step I spliceosome
Yan, C,
Shi, Y,
Zhang, X,
Lei, J,
Zhan, X
|
Science |
2018 |
32329775 |
Structural and functional insights into CWC27/CWC22 heterodimer linking the exon junction complex to spliceosomes
Paternina, JA,
Bensaude, O,
Hocq, R,
Marquenet, E,
Hennion, M,
Basquin, J,
Le Hir, H,
Conti, E,
Namane, A,
Barbosa, I,
Busetto, V
|
Nucleic Acids Res |
2020 |
27683217 |
Stoichiometries of U2AF35, U2AF65 and U2 snRNP reveal new early spliceosome assembly pathways
Vorechovsky, I,
Hudson, AJ,
Eperon, IC,
Chen, L,
Kralovicova, J,
Weinmeister, R,
Eperon, LP
|
Nucleic Acids Res |
2017 |
21441581 |
Spliceosome structure and function
Will, CL,
Lührmann, R
|
Cold Spring Harb Perspect Biol |
2011 |
32517083 |
A Day in the Life of the Exon Junction Complex
Gehring, NH,
Schlautmann, LP
|
Biomolecules |
2020 |
30602541 |
Molecular Mechanisms of pre-mRNA Splicing through Structural Biology of the Spliceosome
Wan, R,
Yan, C,
Shi, Y
|
Cold Spring Harb Perspect Biol |
2019 |
28502770 |
An Atomic Structure of the Human Spliceosome
Yan, C,
Shi, Y,
Zhang, X,
Finci, LI,
Lei, J,
Hang, J
|
Cell |
2017 |
27377154 |
A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity
Tauchert, MJ,
Will, CL,
Rigo, N,
Anokhina, MM,
Agafonov, DE,
Luhrmann, R,
Urlaub, H,
Boesler, C,
Ficner, R,
Kastner, B
|
Nat Commun |
2016 |
22959432 |
CWC22 connects pre-mRNA splicing and exon junction complex assembly
Gehring, NH,
Steckelberg, AL,
Boehm, V,
Gromadzka, AM
|
Cell Rep |
2012 |
30728453 |
Structures of the human spliceosomes before and after release of the ligated exon
Shi, Y,
Liu, D,
Yan, C,
Zhang, W,
Zhang, X,
Lei, J,
Zhan, X
|
Cell Res |
2019 |
26969736 |
Noncanonical registers and base pairs in human 5' splice-site selection
Roca, X,
Zhong, Z,
Ho, JX,
Chen, G,
Tan, J,
Luo, S
|
Nucleic Acids Res |
2016 |
2176635 |
Evidence for base-pairing between mammalian U2 and U6 small nuclear ribonucleoprotein particles
Giglio, LM,
Hausner, TP,
Weiner, AM
|
Genes Dev |
1990 |
31794245 |
RNA Splicing by the Spliceosome
Charenton, C,
Wilkinson, ME,
Nagai, K
|
Annu Rev Biochem |
2020 |
2963332 |
Spliceosome assembly involves the binding and release of U4 small nuclear ribonucleoprotein
Lamond, AI,
Grabowski, PJ,
Sharp, PA,
Konarska, MM
|
Proc. Natl. Acad. Sci. U.S.A. |
1988 |
31815536 |
How Is Precursor Messenger RNA Spliced by the Spliceosome?
Wan, R,
Shi, Y,
Bai, R,
Zhan, X
|
Annu Rev Biochem |
2020 |
24304693 |
Identification of a novel component C2ORF3 in the lariat-intron complex: lack of C2ORF3 interferes with pre-mRNA splicing via intron turnover pathway
Ohno, M,
Yoshimoto, R,
Yoshida, M,
Kataoka, N,
Okawa, K
|
Genes Cells |
2014 |
19536130 |
Exon, intron and splice site locations in the spliceosomal B complex
Lührmann, R,
Deckert, J,
Stark, H,
Merz, C,
Kastner, B,
Wolf, E
|
EMBO J |
2009 |
9731529 |
Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex
Neubauer, G,
Calvio, C,
Rappsilber, J,
Sleeman, J,
Watson, M,
Lamond, A,
King, A,
Mann, M,
Ajuh, P
|
Nat. Genet. |
1998 |
33243851 |
Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation
Bertram, K,
Will, CL,
Lührmann, R,
Leelaram, MN,
Dybkov, O,
Agafonov, DE,
Stark, H,
Urlaub, H,
Townsend, C,
Kastner, B
|
Science |
2020 |
23236153 |
Human spliceosomal protein CWC22 plays a role in coupling splicing to exon junction complex deposition and nonsense-mediated decay
Shu, MD,
Alexandrov, A,
Colognori, D,
Steitz, JA
|
Proc Natl Acad Sci U S A |
2012 |
12477934 |
Protein composition of human prespliceosomes isolated by a tobramycin affinity-selection method.
Hartmuth, K,
Urlaub, H,
Lührmann, R,
Gentzel, M,
Wilm, M,
Vornlocher, HP,
Will, CL
|
Proc Natl Acad Sci U S A |
2002 |
30315277 |
Structures of the human pre-catalytic spliceosome and its precursor spliceosome
Shi, Y,
Yan, C,
Zhang, X,
Lei, J,
Zhan, X
|
Cell Res |
2018 |
32179686 |
Structural basis for DEAH-helicase activation by G-patch proteins
Weber, ME,
Ivanović, L,
Jonas, S,
Studer, MK,
Marti, S
|
Proc Natl Acad Sci U S A |
2020 |
22961380 |
Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly
Barrandon, C,
Haque, N,
Le Hir, H,
Barbosa, I,
Blanchette, M,
Fiorini, F,
Tomasetto, C
|
Nat Struct Mol Biol |
2012 |
19165350 |
TFIP11 interacts with mDEAH9, an RNA helicase involved in spliceosome disassembly
Paine, ML,
Wen, X,
Tannukit, S
|
Int J Mol Sci |
2008 |
30975767 |
Mechanism of 5' splice site transfer for human spliceosome activation
Charenton, C,
Wilkinson, ME,
Nagai, K
|
Science |
2019 |
28062851 |
Human cactin interacts with DHX8 and SRRM2 to assure efficient pre-mRNA splicing and sister chromatid cohesion
Zanini, IM,
Lorenzi, LE,
Azzalin, CM,
Soneson, C
|
J Cell Sci |
2017 |
20423332 |
Contribution of DEAH-box protein DHX16 in human pre-mRNA splicing
Gencheva, M,
Kato, M,
Newo, AN,
Lin, RJ
|
Biochem. J. |
2010 |
12176931 |
Large-scale proteomic analysis of the human spliceosome.
Lamond, AI,
Mann, M,
Rappsilber, J,
Ryder, U
|
Genome Res |
2002 |
11101529 |
Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry
Lamond, AI,
Kuster, B,
Mann, M,
Zomerdijk, JC,
Panov, K,
Ajuh, P
|
EMBO J. |
2000 |
10454621 |
Intron-exon structures of eukaryotic model organisms
Deutsch, M,
Long, M
|
Nucleic Acids Res |
1999 |
22110043 |
Functional mammalian spliceosomal complex E contains SMN complex proteins in addition to U1 and U2 snRNPs
Makarova, OV,
Makarov, EM,
Bottrill, A,
Owen, N
|
Nucleic Acids Res. |
2012 |
28781166 |
Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation
Bertram, K,
Will, CL,
Lührmann, R,
Leelaram, MN,
Dybkov, O,
Haselbach, D,
Agafonov, DE,
Stark, H,
Urlaub, H,
Kastner, B
|
Cell |
2017 |
11991638 |
Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.
Grigorieff, N,
Moore, MJ,
Licklider, LJ,
Gygi, SR,
Jurica, MS
|
RNA |
2002 |
12414731 |
5' exon interactions within the human spliceosome establish a framework for exon junction complex structure and assembly
Moore, MJ,
Reichert, VL,
Jurica, MS,
Le, Hir H
|
Genes Dev |
2002 |
19103666 |
Isolation and characterization of post-splicing lariat-intron complexes
Ohno, M,
Yoshimoto, R,
Okawa, K,
Kataoka, N
|
Nucleic Acids Res. |
2009 |