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Processing of Capped Intron-Containing Pre-mRNA
Stable Identifier
R-HSA-72203
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
,
nuclear envelope
,
cytosol
ReviewStatus
5/5
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Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
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Co-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per gene, which cannot serve as splicing substrates until both 5' and 3' ends of each intron are synthesized. Thus the time that it takes for pol II to synthesize each intron defines a minimal time and distance along the gene in which splicing factors can be recruited. The time that it takes for pol II to reach the end of the gene defines the maximal time in which splicing could occur co-transcriptionally. Thus, the kinetics of transcription can affect the kinetics of splicing.Any covalent change in a primary (nascent) mRNA transcript is mRNA Processing. For successful gene expression, the primary mRNA transcript needs to be converted to a mature mRNA prior to its translation into polypeptide. Eucaryotic mRNAs undergo a series of complex processing reactions; these begin on nascent transcripts as soon as a few ribonucleotides have been synthesized during transcription by RNA Polymerase II, through the export of the mature mRNA to the cytoplasm, and culminate with mRNA turnover in the cytoplasm.
Participants
Events
Internal Methylation of mRNA
(Homo sapiens)
Formation of the Cleavage and Polyadenylation Complex
(Homo sapiens)
Formation of pre-mRNPs
(Homo sapiens)
mRNA Splicing
(Homo sapiens)
mRNA 3'-end processing
(Homo sapiens)
Transport of Mature Transcript to Cytoplasm
(Homo sapiens)
Participates
as an event of
Metabolism of RNA (Homo sapiens)
Orthologous Events
Processing of Capped Intron-Containing Pre-mRNA (Bos taurus)
Processing of Capped Intron-Containing Pre-mRNA (Caenorhabditis elegans)
Processing of Capped Intron-Containing Pre-mRNA (Canis familiaris)
Processing of Capped Intron-Containing Pre-mRNA (Danio rerio)
Processing of Capped Intron-Containing Pre-mRNA (Dictyostelium discoideum)
Processing of Capped Intron-Containing Pre-mRNA (Drosophila melanogaster)
Processing of Capped Intron-Containing Pre-mRNA (Gallus gallus)
Processing of Capped Intron-Containing Pre-mRNA (Mus musculus)
Processing of Capped Intron-Containing Pre-mRNA (Plasmodium falciparum)
Processing of Capped Intron-Containing Pre-mRNA (Rattus norvegicus)
Processing of Capped Intron-Containing Pre-mRNA (Saccharomyces cerevisiae)
Processing of Capped Intron-Containing Pre-mRNA (Schizosaccharomyces pombe)
Processing of Capped Intron-Containing Pre-mRNA (Sus scrofa)
Processing of Capped Intron-Containing Pre-mRNA (Xenopus tropicalis)
Authored
Marzluff, WF (2003-06-05)
Krainer, AR (2003-06-05)
Hastings, ML (2003-06-05)
Wahle, E (2003-06-05)
Hammarskjold, ML (2003-06-05)
Zhang, Z (2003-06-05)
Carmichael, GG (2003-06-05)
Reviewed
Nilsen, TW (2023-11-15)
Created
Krainer, AR (2004-06-23)
Hastings, ML (2004-06-23)
Wahle, E (2004-06-23)
Hammarskjold, ML (2004-06-23)
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