Reactome | RPS14 [cytosol]

RPS14 [cytosol]

Stable Identifier

R-HSA-72333

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

40S small ribosomal protein 14, P06366, 40S ribosomal protein S14, PRO2640

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to starvation (Homo sapiens)
    - Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
      - EIF2AK4 (GCN2) binds tRNA (Homo sapiens)
        
        EIF2AK4:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS14 [cytosol] (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS14 [cytosol] (Homo sapiens)
      - EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS14 [cytosol] (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS14 [cytosol] (Homo sapiens)
      - IMPACT binds GCN1 (Homo sapiens)
        
        GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS14 [cytosol] (Homo sapiens)
        
        IMPACT:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS14 [cytosol] (Homo sapiens)
      - p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS14 [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS14 [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS14 [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS14 [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS14 [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS14 [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS14 [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS14 [cytosol] (Homo sapiens)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS14 [cytosol] (Homo sapiens)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS14 [cytosol] (Homo sapiens)
- rRNA processing (Homo sapiens)
  - rRNA processing in the nucleus and cytosol (Homo sapiens)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
      - 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS14 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62263 RPS14

Gene Names

RPS14, PRO2640

Chain

initiator methionine:, chain:2-151

Reference Genes

BioGPS Gene:6208 RPS14

COSMIC (genes):RPS14 RPS14

CTD Gene:6208 RPS14

dbSNP Gene:6208 RPS14

ENSEMBL:ENSG00000164587 RPS14

ENSEMBL_homo_sapiens_GENE:ENSG00000164587.13 RPS14

HGNC:10387 RPS14

KEGG Gene (Homo sapiens):6208 RPS14

Monarch:6208 RPS14

NCBI Gene:6208 RPS14

OMIM:130620 RPS14

UCSC:P62263 RPS14

Reference Transcript

Other Identifiers

11715540_s_at

11725714_a_at

11725715_x_at

17001674

208645_3p_s_at

208645_PM_s_at

208645_s_at

208646_PM_at

208646_at

2323749

2881414

2881415

2881416

2881417

2881421

2881423

2881426

2881428

2881429

2881430

2881431

32412_at

6208

8115158

A_23_P81492

A_24_P37939

GE80130

GE86729

GO:0000028

GO:0000122

GO:0002181

GO:0002376

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0005840

GO:0005925

GO:0006351

GO:0006355

GO:0006412

GO:0006417

GO:0014069

GO:0015935

GO:0016020

GO:0022626

GO:0022627

GO:0030154

GO:0030218

GO:0030490

GO:0032040

GO:0042254

GO:0042274

GO:0043226

GO:0045182

GO:0045202

GO:0048027

GO:0048856

GO:0065003

GO:0070062

GO:1990904

HMNXSV003039360

HMNXSV003046014

HMNXSV003053506

Hs.244621.3.S1_3p_at

ILMN_1666635

ILMN_2338785

M13934_cds2_at

TC05001937.hg

TC05003306.hg

g7959918_3p_a_at

g7959918_3p_at

g7959918_3p_x_at

Participates

as a component of

40S ribosomal complex [cytosol] (Homo sapiens)

Other forms of this molecule

RPS14 [nucleoplasm]

Inferred To

Homologues of RPS14 [cytosol] (Schizosaccharomyces pombe)

fa92e08 [cytosol] (Danio rerio)

RPS14 [cytosol] (Bos taurus)

RPS14 [cytosol] (Canis familiaris)

RPS14 [cytosol] (Gallus gallus)

RPS14 [cytosol] (Sus scrofa)

Ghost homologue of RPS14 [cytosol] (Drosophila melanogaster)

Ghost homologue of RPS14 [cytosol] (Plasmodium falciparum)

Ghost homologue of RPS14 [cytosol] (Xenopus tropicalis)

rps-14 [cytosol] (Caenorhabditis elegans)

rps14 [cytosol] (Dictyostelium discoideum)

rps1401 [cytosol] (Schizosaccharomyces pombe)

Rps14 [cytosol] (Mus musculus)

Rps14 [cytosol] (Rattus norvegicus)

RPS14B [cytosol] (Saccharomyces cerevisiae)

rps1402 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_005608.1, NP_001020241.1, NP_001020242.1

OpenTargets

ENSG00000164587

HPA

ENSG00000164587-RPS14

GeneCards

P62263

Ensembl

ENST00000407193, ENST00000521466, ENST00000401695, ENSP00000428509, ENSP00000385425, ENSG00000164587, ENSP00000311028, ENST00000312037, ENSP00000385958

PRO

P62263

Pharos - Targets

P62263

Orphanet

17749

PDB

6QZP, 5AJ0, 6ZXD, 4UG0, 7WTV, 7TQL, 6ZVH, 7QP7, 6Y2L, 6IP5, 5A2Q, 8G5Y, 6G5H, 7K5I, 6IP8, 6ZMI, 7WTS, 5FLX, 7XNY, 6OLG, 6ZP4, 6OLF, 6Z6N, 6ZUO, 6ZM7, 4V6X, 6ZXH, 6G53, 7WTZ, 7MQ9, 6ZLW, 6Z6M, 6ZON, 6G4W, 6ZXG, 5T2C, 7WTX, 6ZMT, 6G4S, 6ZXE, 7R4X, 6OM0, 6FEC, 7WTU, 8G61, 7A09, 7QP6, 6G5I, 6ZMO, 8GLP, 6IP6, 6OLI, 8G60, 7WTT, 6Y0G, 6YBD, 6ZV6, 6ZME, 7XNX, 6XA1, 6OLE, 7MQA, 5LKS, 6Z6L, 8G6J, 5VYC, 5OA3, 6ZOK, 6ZN5, 6ZMW, 6G51, 6G18, 7WU0, 7MQ8, 8T4S, 6OM7, 6ZXF, 6YBW, 6ZOJ, 7WTW, 6Y57, 6OLZ

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13601 KRR1	1	KRR1 [nucleoplasm] (R-HSA-6790611)	0.666	4
UniProt:Q9Y3D8 AK6	1	AK6 [nucleoplasm] (R-HSA-6788786)	0.666	4
UniProt:O00233 PSMD9	2	PSMD9 [nucleoplasm] (R-HSA-174321) PSMD9 [cytosol] (R-HSA-68810)	0.611	3
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.597	3
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.569	6
UniProt:P61247 RPS3A	2	RPS3A [nucleoplasm] (R-HSA-6791182) RPS3A [cytosol] (R-HSA-72373)	0.564	2
UniProt:Q16594 TAF9	1	TAF9 [nucleoplasm] (R-HSA-212452)	0.553	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.495	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	12
UniProt:Q00005 2ABB			0.462	2

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