Reactome | RPS2 [cytosol]

RPS2 [cytosol]

Stable Identifier

R-HSA-72347

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

40S small ribosomal protein 2, P15880, 40S ribosomal protein S2, S4, LLREP3 protein

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Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to starvation (Homo sapiens)
    - Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
      - EIF2AK4 (GCN2) binds tRNA (Homo sapiens)
        
        EIF2AK4:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS2 [cytosol] (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS2 [cytosol] (Homo sapiens)
      - EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS2 [cytosol] (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS2 [cytosol] (Homo sapiens)
      - IMPACT binds GCN1 (Homo sapiens)
        
        GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS2 [cytosol] (Homo sapiens)
        
        IMPACT:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS2 [cytosol] (Homo sapiens)
      - p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS2 [cytosol] (Homo sapiens)

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Signaling by ROBO receptors (Homo sapiens)
      - Regulation of expression of SLITs and ROBOs (Homo sapiens)
        
        Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS2 [cytosol] (Homo sapiens)
        
        Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS2 [cytosol] (Homo sapiens)
        
        Translation of ROBO3.2 mRNA is negatively regulated by NMD (Homo sapiens)
        
        Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P15880 RPS2

Gene Names

RPS2, RPS4

Chain

initiator methionine:, chain:2-293

Reference Genes

BioGPS Gene:6187 RPS2

COSMIC (genes):RPS2 RPS2

CTD Gene:6187 RPS2

dbSNP Gene:6187 RPS2

ENSEMBL:ENSG00000140988 RPS2

HGNC:10404 RPS2

KEGG:hsa:6187 RPS2

Monarch:6187 RPS2

NCBI Gene:6187 RPS2

OMIM:603624 RPS2

UCSC:P15880 RPS2

Reference Transcript

RefSeq:NM_002952.3 RPS2

Other Identifiers

11756061_x_at

11757117_at

16822889

16822892

16822904

16822913

16822917

16822919

203107_3p_x_at

203107_PM_x_at

203107_x_at

212433_PM_x_at

212433_x_at

217466_PM_x_at

217466_x_at

221798_3p_x_at

221798_PM_x_at

221798_x_at

2331692

2331695

2335812

2363662

2373983

2414433

2475662

2475664

2491307

2785960

2785961

2787747

2907930

2954754

2954763

31527_at

3322248

3433833

3433834

3433835

3433836

3433837

3433838

3433839

3571878

3581198

3606530

3676301

3676302

3676303

3676304

3676305

3676306

3676307

3676308

3676309

3676310

3676311

3676312

3676313

3676314

3676315

3676316

3676317

3676318

3676319

3676320

3676321

3676322

3676323

3676324

3676325

3748826

3748828

3748829

3748830

3748831

3748832

3748833

3748834

3748836

3763019

3882787

3907385

3907388

4005753

4005754

6187

72997_f_at

7998655

7998664

7998666

8013348

8041204

8172154

89980_s_at

A_21_P0000236

A_21_P0000237

A_24_P919460

A_33_P3563369

GO:0002181

GO:0003723

GO:0003729

GO:0003735

GO:0005198

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005840

GO:0005925

GO:0006412

GO:0015935

GO:0016020

GO:0017134

GO:0019899

GO:0022626

GO:0022627

GO:0043226

GO:0044391

GO:0045296

GO:0051443

GO:0070062

GO:1990904

HMNXSV003002122

HMNXSV003009087

HMNXSV003024132

HMNXSV003056869

Hs.182426.2.S1_3p_x_at

Hs.182426.3.A1_3p_a_at

Hs.182426.4.A1_3p_a_at

Hs.182426.4.A1_3p_at

Hs.182426.4.A1_3p_x_at

ILMN_1688749

ILMN_1709604

ILMN_1737074

ILMN_2133360

ILMN_2189842

ILMN_2218277

PH_hs_0030566

PH_hs_0039080

RNA33480|snoRNA_scaRNA_76_134

RNA33498|snoRNA_scaRNA_94_133

TC02000198.hg

TC16000768.hg

TC16000769.hg

TC17002540.hg

X17206_at

g4506718_3p_a_at

g4506718_3p_x_at

Participates

as an input of

PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Homo sapiens)

as a component of

40S ribosomal complex [cytosol] (Homo sapiens)

This entity regulates

Positively

30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Homo sapiens)

Other forms of this molecule

Me2aR-RPS2 [cytosol]

RPS2 [nucleoplasm]

Inferred To

AABR07029195.1 [cytosol] (Rattus norvegicus)

Rps2 [cytosol] (Mus musculus)

Rps2 [cytosol] (Rattus norvegicus)

LOC608162 [cytosol] (Canis familiaris)

rps-2 [cytosol] (Caenorhabditis elegans)

RPS2 [cytosol] (Bos taurus)

RPS2 [cytosol] (Gallus gallus)

RPS2 [cytosol] (Plasmodium falciparum)

RPS2 [cytosol] (Saccharomyces cerevisiae)

RPS2 [cytosol] (Sus scrofa)

RpS2 [cytosol] (Drosophila melanogaster)

rps2 [cytosol] (Danio rerio)

rps2 [cytosol] (Dictyostelium discoideum)

rps2 [cytosol] (Schizosaccharomyces pombe)

rps2 [cytosol] (Xenopus tropicalis)

Homologues of RPS2 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_002943.2

OpenTargets

ENSG00000140988

ENSEMBL

ENST00000709238, ENSP00000341885, ENSP00000517575

HPA

ENSG00000140988-RPS2

PRO

P15880

Pharos - Targets

P15880

GlyGen

P15880

PDB

6ZM7, 6YBW, 6ZOK, 6IP6, 6YBD, 6ZXE, 6G5I, 6ZP4, 6IP8, 6G5H, 6ZXD, 6XA1, 6ZXF, 6ZUO, 7TQL, 6Y2L, 6ZXG, 7JQC, 8G5Y, 6G4S, 8G61, 6OLF, 8JDL, 6OLZ, 5LKS, 8G6J, 4UG0, 7WTW, 6Y0G, 8G5Z, 8T4S, 8Y0X, 8JDK, 8Y0W, 6OLE, 8JDM, 6G51, 5A2Q, 6ZMT, 7WTV, 6Z6N, 6OLI, 7XNY, 7WTX, 7WTZ, 7QP7, 8OZ0, 6ZLW, 6IP5, 5T2C, 6QZP, 7JQB, 5FLX, 6Y57, 7WU0, 7A09, 6ZON, 6ZXH, 5OA3, 8GLP, 6ZME, 5AJ0, 8IFE, 6ZVJ, 8JDJ, 8PPK, 6OM7, 7R4X, 7K5I, 8PPL, 6Z6M, 7QVP, 6ZN5, 6OM0, 8G60, 6Z6L, 4V6X, 6ZMI, 6G18, 7XNX, 5VYC, 6G53, 6OLG, 6ZMO, 6ZOJ, 6ZMW, 8IFD, 6ZV6, 6ZVH, 7QP6

Interactors (71)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60678 PRMT3	1	PRMT3 [cytosol] (R-HSA-8876692)	0.806	8
UniProt:Q9H0A0 NAT10	1	NAT10 [nucleoplasm] (R-HSA-6791008)	0.669	4
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.642	4
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.638	3
UniProt:Q16342 PDCD2			0.623	3
UniProt:Q9NQZ2 UTP3	1	UTP3 [nucleoplasm] (R-HSA-6790637)	0.615	4
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.615	3
UniProt:P46781 RPS9	2	RPS9 [cytosol] (R-HSA-72387) RPS9 [nucleoplasm] (R-HSA-6790663)	0.564	2
UniProt:P60520 GABARAPL2	3	GABARAPL2 [cytosol] (R-HSA-5671758) GABARAPL2(1-117) [cytosol] (R-HSA-5682641) GABARAPL2 [autophagosome membrane] (R-HSA-5683633)	0.547	2
UniProt:P0DTD1-PRO_0000449619 REP			0.528	3
UniProt:Q8NFQ8 TOIP2			0.527	2
UniProt:Q6NSZ9 ZSCAN25	1	ZSCAN25 [nucleoplasm] (R-HSA-1247859)	0.527	3
UniProt:Q96QR8 PURB			0.527	3
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	3
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.527	3
UniProt:Q9BTD8 RBM42	1	RBM42 [nucleoplasm] (R-HSA-9769526)	0.527	2
UniProt:P13693 TCTP			0.527	2
UniProt:P62269 RPS18	2	RPS18 [cytosol] (R-HSA-72341) RPS18 [nucleoplasm] (R-HSA-6798701)	0.527	2
UniProt:Q9NY61 AATF	1	AATF [cytosol] (R-HSA-205071)	0.527	3
UniProt:Q9NRM2 ZN277			0.527	3
UniProt:Q96NT1 NP1L5			0.527	2
UniProt:P84098 RPL19	1	RPL19 [cytosol] (R-HSA-72424)	0.527	3
UniProt:Q86TS9 MRPL52	1	MRPL52 [mitochondrial inner membrane] (R-HSA-5368187)	0.527	2
UniProt:Q07021 C1QBP	3	C1QBP [plasma membrane] (R-HSA-158123) C1QBP [mitochondrial matrix] (R-HSA-9645697) C1QBP [cytosol] (R-HSA-9645690)	0.527	3
UniProt:O14730 RIOK3	1	RIOK3 [cytosol] (R-HSA-6791522)	0.527	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q15050 RRS1			0.527	3
UniProt:P61247 RPS3A	2	RPS3A [cytosol] (R-HSA-72373) RPS3A [nucleoplasm] (R-HSA-6791182)	0.527	3
UniProt:P58557 YBEY			0.527	2
UniProt:Q02539 H1-1	1	HIST1H1A [nucleoplasm] (R-HSA-211245)	0.527	2
UniProt:O00566 MPHOSPH10	1	MPHOSPH10 [nucleoplasm] (R-HSA-6790661)	0.527	3
UniProt:Q1ED39 KNOP1			0.527	2
UniProt:O00567 NOP56	2	NOP56 [nucleoplasm] (R-HSA-6790696) NOP56 [cytosol] (R-HSA-391293)	0.527	2
UniProt:P10412 H1-4	1	HIST1H1E [nucleoplasm] (R-HSA-211251)	0.527	3
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	6
UniProt:P08708 RPS17	2	RPS17 [cytosol] (R-HSA-72339) RPS17 [nucleoplasm] (R-HSA-6798719)	0.527	3
UniProt:P05455 SSB	1	SSB [nucleoplasm] (R-HSA-58418)	0.527	2
UniProt:O75533 SF3B1	1	SF3B1 [nucleoplasm] (R-HSA-71968)	0.527	3
UniProt:Q9ULX3 NOB1	2	NOB1 [nucleoplasm] (R-HSA-6791536) NOB1 [cytosol] (R-HSA-6791524)	0.527	2
UniProt:Q9NQ92 COPRS	1	COPRS [nucleoplasm] (R-HSA-5212681)	0.527	2
UniProt:Q13601 KRR1	1	KRR1 [nucleoplasm] (R-HSA-6790611)	0.527	3
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.527	3
UniProt:Q9Y2T7 YBOX2			0.527	3
UniProt:P54105 CLNS1A	1	CLNS1A [cytosol] (R-HSA-191796)	0.527	2
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.527	2
UniProt:Q9UII4 HERC5	1	HERC5 [cytosol] (R-HSA-936553)	0.527	2
UniProt:Q9BRP1 PDD2L			0.527	4
UniProt:Q5C9Z4 NOM1			0.527	2
UniProt:O95793 STAU1			0.527	2
UniProt:Q8TBF4 ZCRB1	2	ZCRB1 [cytosol] (R-HSA-9682010) ZCRB1 [nucleoplasm] (R-HSA-6787853)	0.527	3
UniProt:Q96GM8 TOE1			0.527	3
UniProt:Q96GA3 LTV1	2	LTV1 [cytosol] (R-HSA-6791520) LTV1 [nucleoplasm] (R-HSA-6791566)	0.527	3
UniProt:Q6P158 DHX57			0.527	3
UniProt:P62750 RPL23A	1	RPL23A [cytosol] (R-HSA-72432)	0.527	3
UniProt:Q8IWX8 CHERP	1	CHERP [nucleoplasm] (R-HSA-8865901)	0.527	3
UniProt:Q5JTH9 RRP12			0.527	2
UniProt:Q9NXF1 TEX10	1	TEX10 [nucleoplasm] (R-HSA-3826589)	0.527	3
UniProt:P23396 RPS3	2	RPS3 [cytosol] (R-HSA-72369) RPS3 [nucleoplasm] (R-HSA-6798714)	0.527	3
UniProt:Q2NL82 TSR1	2	TSR1 [nucleoplasm] (R-HSA-6791574) TSR1 [cytosol] (R-HSA-6791570)	0.527	2
UniProt:Q9BRS2 RIOK1	2	RIOK1 [nucleoplasm] (R-HSA-5226890) RIOK1 [cytosol] (R-HSA-6791525)	0.527	3
UniProt:P62841 RPS15	2	RPS15 [cytosol] (R-HSA-72335) RPS15 [nucleoplasm] (R-HSA-6798706)	0.527	3
UniProt:P62249 RPS16	2	RPS16 [cytosol] (R-HSA-72337) RPS16 [nucleoplasm] (R-HSA-6791196)	0.527	3
UniProt:P16104 H2AFX	7	H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317)	0.527	2
UniProt:Q9UPY3 DICER1	1	DICER1 [cytosol] (R-HSA-203820)	0.527	2
UniProt:P62979 RPS27A	20	RPS27A(1-76) [endocytic vesicle membrane] (R-HSA-939208) RPS27A(77-156) [nucleoplasm] (R-HSA-6798734) Ub-33-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783024) Ub-63-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783200) Ub-6-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783040) Ub-11-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783085) Ub-48-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783075) Ub-29-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783146) Ub-63-RPS27A(1-76) [cytosol] (R-HSA-939248) RPS27A(1-76) [lysosomal lumen] (R-HSA-9660001) RPS27A(1-76) [cytosol] (R-HSA-939205) p-S65-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-9834951) Ub-48-RPS27A(1-76) [cytosol] (R-HSA-939202) RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-9834993) RPS27A(1-76) [late endosome lumen] (R-HSA-9660022) Ub-6-RPS27A(1-76) [nucleoplasm] (R-HSA-6782608) Ub-63-RPS27A(1-76) [nucleoplasm] (R-HSA-6782503) Ub-48-RPS27A(1-76) [nucleoplasm] (R-HSA-5683037) RPS27A(1-76) [nucleoplasm] (R-HSA-939849) Ub-11-RPS27A(1-76) [cytosol] (R-HSA-3095933)	0.527	2
UniProt:P08865 RPSA	2	RPSA [cytosol] (R-HSA-72389) RPSA [nucleoplasm] (R-HSA-6798722)	0.527	3
UniProt:P46782 RPS5	2	RPS5 [cytosol] (R-HSA-72379) RPS5 [nucleoplasm] (R-HSA-6791188)	0.527	3
UniProt:P46783 RPS10	2	RPS10 [cytosol] (R-HSA-72325) RPS10 [nucleoplasm] (R-HSA-6798733)	0.527	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	12
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.483	2
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.462	2

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