Reactome | RPS21 [cytosol]

RPS21 [cytosol]

Stable Identifier

R-HSA-72351

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

40S small ribosomal protein 21, P35265, 40S ribosomal protein S21

Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to starvation (Homo sapiens)
    - Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
      - EIF2AK4 (GCN2) binds tRNA (Homo sapiens)
        
        EIF2AK4:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS21 [cytosol] (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS21 [cytosol] (Homo sapiens)
      - EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS21 [cytosol] (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS21 [cytosol] (Homo sapiens)
      - IMPACT binds GCN1 (Homo sapiens)
        
        GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS21 [cytosol] (Homo sapiens)
        
        IMPACT:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS21 [cytosol] (Homo sapiens)
      - p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS21 [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS21 [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS21 [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS21 [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS21 [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS21 [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS21 [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS21 [cytosol] (Homo sapiens)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS21 [cytosol] (Homo sapiens)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS21 [cytosol] (Homo sapiens)
- rRNA processing (Homo sapiens)
  - rRNA processing in the nucleus and cytosol (Homo sapiens)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
      - 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS21 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P63220 RPS21

Gene Names

RPS21

Chain

chain:1-83

Reference Genes

BioGPS Gene:6227 RPS21

COSMIC (genes):RPS21 RPS21

CTD Gene:6227 RPS21

dbSNP Gene:6227 RPS21

ENSEMBL:ENSG00000171858 RPS21

HGNC:10409 RPS21

KEGG:hsa:6227 RPS21

Monarch:6227 RPS21

NCBI Gene:6227 RPS21

OMIM:180477 RPS21

UCSC:P63220 RPS21

Reference Transcript

RefSeq:NM_001024.3 RPS21

Other Identifiers

11715357_s_at

16915676

200834_PM_s_at

200834_s_at

214097_PM_at

214097_at

32744_at

3892665

3892667

3892668

3892669

3892670

3892671

3892672

3892673

3892674

3892675

3892676

3892677

3892679

59703_s_at

6227

8063903

A_14_P122003

A_23_P120660

A_24_P280803

A_33_P3239569

GO:0000447

GO:0000461

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005654

GO:0005737

GO:0005783

GO:0005791

GO:0005829

GO:0005840

GO:0006412

GO:0015935

GO:0022626

GO:0022627

GO:0043226

GO:0045202

GO:1990904

HMNXSV003020102

HMNXSV003038175

HMNXSV003047880

ILMN_1800573

L04483_s_at

TC20000489.hg

g4506698_3p_a_at

Participates

as a component of

40S ribosomal complex [cytosol] (Homo sapiens)

Other forms of this molecule

RPS21 [nucleoplasm]

Inferred To

rps-21 [cytosol] (Caenorhabditis elegans)

rps21 [cytosol] (Danio rerio)

rps21 [cytosol] (Dictyostelium discoideum)

rps21 [cytosol] (Schizosaccharomyces pombe)

rps21 [cytosol] (Xenopus tropicalis)

RPS21 [cytosol] (Bos taurus)

RPS21 [cytosol] (Canis familiaris)

RPS21 [cytosol] (Gallus gallus)

RPS21 [cytosol] (Plasmodium falciparum)

RPS21 [cytosol] (Sus scrofa)

RPS21B [cytosol] (Saccharomyces cerevisiae)

RpS21 [cytosol] (Drosophila melanogaster)

Rps21 [cytosol] (Mus musculus)

Rps21 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001015.1

OpenTargets

ENSG00000171858

ENSEMBL

ENST00000343986, ENSP00000345957

HPA

ENSG00000171858-RPS21

PRO

P63220

Pharos - Targets

P63220

GlyGen

P63220

PDB

6YBD, 6ZM7, 6XA1, 6Y2L, 7TQL, 7JQC, 6ZUO, 7WTZ, 7XNY, 7WTX, 6Z6N, 8G6J, 6ZVH, 7QVP, 7WTW, 6Y0G, 6G53, 8XXL, 6ZMT, 7WTV, 8XXN, 5A2Q, 8G5Z, 6OM0, 6G4S, 8G61, 8QOI, 8JDJ, 7K5I, 8PPK, 6OM7, 8IFE, 7R4X, 6ZVJ, 6ZXH, 5AJ0, 5OA3, 5FLX, 6Y57, 5T2C, 6QZP, 6ZON, 6IP5, 7QP7, 6ZLW, 8OZ0, 7A09, 7WU0, 7JQB, 6ZME, 8GLP, 6ZMO, 6ZMW, 6ZOJ, 8IFD, 6ZV6, 4V6X, 8XXM, 6OLI, 6Z6L, 6Z6M, 6ZN5, 8G60, 8PPL, 6OLG, 6ZMI, 5VYC, 6G51, 7XNX, 6G18, 6OLZ, 8Y0W, 8JDM, 8JDK, 6OLE, 8T4S, 8Y0X, 4UG0, 6OLF, 8JDL, 5LKS, 8G5Y, 6ZXF, 6ZXG, 6ZXD, 6G5H, 6G5I, 6ZXE, 6IP8, 6ZP4, 6YBW, 6IP6, 6ZOK, 7QP6

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.638	3
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.527	2

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