Reactome | RPS3 [cytosol]

RPS3 [cytosol]

Stable Identifier

R-HSA-72369

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

40S small ribosomal protein 3, P23396, 40S ribosomal protein S3

Locations in the PathwayBrowser

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Cellular responses to external stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
    - EIF2AK4 (GCN2) binds tRNA (Homo sapiens)
      - EIF2AK4:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS3 [cytosol] (Homo sapiens)
      - tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS3 [cytosol] (Homo sapiens)
    - EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)
      - tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS3 [cytosol] (Homo sapiens)
      - tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS3 [cytosol] (Homo sapiens)
    - IMPACT binds GCN1 (Homo sapiens)
      - GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS3 [cytosol] (Homo sapiens)
      - IMPACT:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS3 [cytosol] (Homo sapiens)
    - p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
      - tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS3 [cytosol] (Homo sapiens)

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Signaling by ROBO receptors (Homo sapiens)
      - Regulation of expression of SLITs and ROBOs (Homo sapiens)
        
        Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS3 [cytosol] (Homo sapiens)
        
        Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS3 [cytosol] (Homo sapiens)
        
        Translation of ROBO3.2 mRNA is negatively regulated by NMD (Homo sapiens)
        
        Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS3 [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS3 [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS3 [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS3 [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS3 [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS3 [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS3 [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS3 [cytosol] (Homo sapiens)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS3 [cytosol] (Homo sapiens)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS3 [cytosol] (Homo sapiens)
- rRNA processing (Homo sapiens)
  - rRNA processing in the nucleus and cytosol (Homo sapiens)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
      - 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P23396 RPS3

Gene Names

RPS3, OK/SW-cl.26

Chain

initiator methionine:1, chain:2-243

Reference Genes

BioGPS Gene:6188 RPS3

COSMIC (genes):RPS3 RPS3

CTD Gene:6188 RPS3

dbSNP Gene:6188 RPS3

ENSEMBL:ENSG00000149273 RPS3

HGNC:10420 RPS3

KEGG Gene (Homo sapiens):6188 RPS3

Monarch:6188 RPS3

NCBI Gene:6188 RPS3

OMIM:600454 RPS3

UCSC:P23396 RPS3

Reference Transcript

Other Identifiers

0000840066

11757264_s_at

16729103

208692_at

214208_at

2940643

2940649

3340547

3340552

3340553

3340554

3340555

3340557

3340558

3340559

3340560

3340561

3340562

3340565

3340566

3340567

3340568

3340569

3340570

3340571

3340572

3340577

34645_at

6188

63493_at

7942586

A_14_P112056

A_23_P139376

A_24_P218765

GE79155

GE84158

GO:0000184

GO:0000977

GO:0002376

GO:0003674

GO:0003677

GO:0003684

GO:0003723

GO:0003729

GO:0003735

GO:0003906

GO:0004518

GO:0004520

GO:0005198

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005739

GO:0005743

GO:0005759

GO:0005783

GO:0005819

GO:0005829

GO:0005840

GO:0005844

GO:0005856

GO:0005886

GO:0005925

GO:0006259

GO:0006281

GO:0006412

GO:0006413

GO:0006417

GO:0006464

GO:0006605

GO:0006614

GO:0006810

GO:0006915

GO:0006950

GO:0006974

GO:0007010

GO:0007049

GO:0007059

GO:0007155

GO:0007165

GO:0008017

GO:0008092

GO:0008134

GO:0008150

GO:0008219

GO:0008283

GO:0009056

GO:0009058

GO:0010628

GO:0014069

GO:0015031

GO:0015631

GO:0015935

GO:0016020

GO:0016829

GO:0017148

GO:0019083

GO:0019843

GO:0019899

GO:0019900

GO:0019901

GO:0022607

GO:0022627

GO:0030544

GO:0031116

GO:0031334

GO:0031397

GO:0032079

GO:0032357

GO:0032358

GO:0032587

GO:0032743

GO:0032991

GO:0034614

GO:0034641

GO:0034655

GO:0042104

GO:0042769

GO:0042981

GO:0043226

GO:0043507

GO:0044390

GO:0044403

GO:0044877

GO:0045202

GO:0045738

GO:0045739

GO:0050862

GO:0051018

GO:0051092

GO:0051225

GO:0051301

GO:0051536

GO:0051879

GO:0061481

GO:0065003

GO:0070062

GO:0070181

GO:0070301

GO:0071159

GO:0071356

GO:0072686

GO:0097100

GO:0140078

GO:1901224

GO:1902231

GO:1902546

GO:1905053

GO:1990904

GO:2001235

GO:2001272

Hs.59728.0.A1_3p_at

TC11000806.hg

X55715_at

g555940_3p_at

Participant Of

hasComponent

40S ribosomal complex [cytosol]

Other forms of this molecule

RPS3 [nucleoplasm]

Inferred To

Rps3 [cytosol] (Mus musculus)

Rps3 [cytosol] (Rattus norvegicus)

Homologues of RPS3 [cytosol] (Sus scrofa)

RPS3 [cytosol] (Bos taurus)

RPS3 [cytosol] (Canis familiaris)

RPS3 [cytosol] (Gallus gallus)

RPS3 [cytosol] (Plasmodium falciparum)

RPS3 [cytosol] (Saccharomyces cerevisiae)

RPS3 [cytosol] (Sus scrofa)

RpS3 [cytosol] (Drosophila melanogaster)

rps3 [cytosol] (Danio rerio)

rps3 [cytosol] (Dictyostelium discoideum)

rps3 [cytosol] (Schizosaccharomyces pombe)

rps3 [cytosol] (Xenopus tropicalis)

rps-3 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001247436.1, NP_001247435.1, NP_001243731.1, NP_000996.2

Target Pathogen

5b354852be737e166372e901

OpenTargets

ENSG00000149273

GeneCards

P23396

HPA

ENSG00000149273-RPS3

Ensembl

ENSP00000433821, ENST00000527446, ENSG00000149273, ENST00000531188, ENSP00000278572, ENST00000278572, ENSP00000434643, ENSP00000436971, ENST00000524851

PRO

P23396

PDB

1WH9, 6Y0G, 5OA3, 6FEC, 6IP8, 6OM0, 6Y2L, 6G51, 6G5I, 6G5H, 5AJ0, 6OLG, 6IP5, 4UG0, 6IP6, 6OLI, 6OLE, 6ZOL, 6EK0, 5FLX, 5A2Q, 6OLF, 5VYC, 5LKS, 5T2C, 6QZP, 6OLZ, 6G53, 4V6X, 6ZOJ, 6OM7, 6Y57

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q04206 RELA	6	MeK310-RELA [nucleoplasm] (R-HSA-8865233) SUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) RELA [nucleoplasm] (R-HSA-177676) RELA [cytosol] (R-HSA-168172)	0.797	8
UniProt:Q00987 MDM2	11	SUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.696	8
UniProt:P25963 NFKBIA	10	SUMO1-K21-NFKBIA [nucleoplasm] (R-HSA-4656935) PolyUb-NFKBIA [cytosol] (R-HSA-6782960) p-S32,S36-NFKBIA [cytosol] (R-HSA-177677) K48PolyUb-K21,22-p-S32,S36-IkBA [cytosol] (R-HSA-5607659) NFKBIA [cytosol] (R-HSA-168151) Ub-21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-1168581) NFKBIA S32I [cytosol] (R-HSA-5228846) NFKBIA F2_M37del [cytosol] (R-HSA-9630119) NFKBIA M37K [cytosol] (R-HSA-5228805) NFKBIA [nucleoplasm] (R-HSA-4656929)	0.677	6
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.642	4
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.632	4
UniProt:P19838 NFKB1	8	NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-968) [cytosol] (R-HSA-451607) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) 3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619)	0.623	5
UniProt:Q15843 NEDD8	17	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) K1881-CUL9-G76-NEDD8 [cytosol] (R-HSA-8955924) NEDD8 [nucleoplasm] (R-HSA-8955926) K705-CUL4A-G76-NEDD8 [nucleoplasm] (R-HSA-8952528) K859-CUL4B-G76-NEDD8 [nucleoplasm] (R-HSA-8952538) NEDD8(77-88) [cytosol] (R-HSA-6782654) NEDD8(1-88) [cytosol] (R-HSA-5690794) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739) K720-CUL1-G76-NEDD8 [cytosol] (R-HSA-8952534) K712-CUL3-G76-NEDD8 [cytosol] (R-HSA-8952531) K689-CUL2-G76-NEDD8 [cytosol] (R-HSA-8952526) K724-CUL5-G76-NEDD8 [cytosol] (R-HSA-8952018) NEDD8 [cytosol] (R-HSA-416969) K567-TGFBR2-G76-NEDD8 [cytosol] (R-HSA-4419906) K556-TGFBR2-G76-NEDD8 [cytosol] (R-HSA-4419907) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895)	0.623	3
UniProt:O14920 IKBKB	3	p-S177,S181-IKBKB [cytosol] (R-HSA-202506) IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518) IKBKB [cytosol] (R-HSA-168114)	0.602	4
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.564	2
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q96GA3 LTV1	2	LTV1 [nucleoplasm] (R-HSA-6791566) LTV1 [cytosol] (R-HSA-6791520)	0.556	3

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