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What is Reactome ?
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Digital Preservation
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RPS3 [cytosol]
Stable Identifier
R-HSA-72369
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
40S small ribosomal protein 3, P23396, 40S ribosomal protein S3
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to starvation (Homo sapiens)
Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
EIF2AK4 (GCN2) binds tRNA (Homo sapiens)
EIF2AK4:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)
tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
IMPACT binds GCN1 (Homo sapiens)
GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
IMPACT:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
Regulation of expression of SLITs and ROBOs (Homo sapiens)
Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
Translation of ROBO3.2 mRNA is negatively regulated by NMD (Homo sapiens)
Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Influenza Infection (Homo sapiens)
Influenza Viral RNA Transcription and Replication (Homo sapiens)
Viral mRNA Translation (Homo sapiens)
Synthesis of PB1-F2 (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
Viral Protein Synthesis (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
SARS-CoV-1-host interactions (Homo sapiens)
SARS-CoV-1 modulates host translation machinery (Homo sapiens)
SARS-CoV-1 nsp1 binds to 40S ribosomal subunit (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
40S ribosomal complex:nsp1 [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 modulates host translation machinery (Homo sapiens)
SARS-CoV-2 nsp1 binds to 40S ribosomal complex (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
40S ribosomal complex:nsp1 [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Selenoamino acid metabolism (Homo sapiens)
Selenocysteine synthesis (Homo sapiens)
80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC (Homo sapiens)
80S:Met-tRNAi:mRNA:SECISBP2:Sec [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
Sec-tRNA(Sec):EEFSEC:GTP binds to 80S Ribosome (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Nonsense-Mediated Decay (NMD) (Homo sapiens)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
rRNA processing (Homo sapiens)
rRNA processing in the nucleus and cytosol (Homo sapiens)
Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Elongation (Homo sapiens)
Peptide chain elongation (Homo sapiens)
Aminoacyl-tRNA binds to the ribosome at the A-site (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
80S:aminoacyl tRNA:mRNA:eEF1A:GTP [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
Hydrolysis of eEF1A:GTP (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA:aminoacyl-tRNA [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
80S:aminoacyl tRNA:mRNA:eEF1A:GTP [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
Peptide transfer from P-site tRNA to the A-site tRNA (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA:aminoacyl-tRNA [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
Elongation complex with growing peptide chain [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
Translocation of ribosome by 3 bases in the 3' direction (Homo sapiens)
80S Ribosome:mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
Elongation complex with growing peptide chain [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Homo sapiens)
Translation initiation complex formation (Homo sapiens)
Formation of translation initiation complexes containing mRNA that does not circularize (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
Formation of a pool of free 40S subunits (Homo sapiens)
Release of 40S and 60S subunits from the 80S ribosome (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
eIF3 and eIF1A bind to the 40S subunit (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
40S:eIF3:eIF1A [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
Formation of the ternary complex, and subsequently, the 43S complex (Homo sapiens)
Formation of the 43S pre-initiation complex (Homo sapiens)
40S:eIF3:eIF1A [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
GTP hydrolysis and joining of the 60S ribosomal subunit (Homo sapiens)
The 60S subunit joins the translation initiation complex (Homo sapiens)
40S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
eIF2:GTP is hydrolyzed, eIFs are released (Homo sapiens)
40S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
eIF5B:GTP is hydrolyzed and released (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
Ribosomal scanning and start codon recognition (Homo sapiens)
Ribosomal scanning (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
Start codon recognition (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
L13a-mediated translational silencing of Ceruloplasmin expression (Homo sapiens)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
Eukaryotic Translation Termination (Homo sapiens)
GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex (Homo sapiens)
Me-Q185-ETF1 dimer:eRF3:GDP:80S Ribosome:mRNA:peptidyl-tRNA Complex [cytosol] (Homo sapiens)
80S Ribosome:mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
Me-Q185-ETF1 dimer:eRF3:GTP:80S Ribosome:mRNA:peptidyl-tRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex (Homo sapiens)
80S Ribosome:mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
Me-Q185-ETF1 dimer:eRF3:GTP:80S Ribosome:mRNA:peptidyl-tRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex (Homo sapiens)
Me-Q185-ETF1 dimer:eRF3:GDP:80S Ribosome:mRNA:peptidyl-tRNA Complex [cytosol] (Homo sapiens)
80S Ribosome:mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
Me-Q185-ETF1 dimer:eRF3:GDP:80S Ribosome:mRNA:tRNA Complex [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
SRP-dependent cotranslational protein targeting to membrane (Homo sapiens)
Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Homo sapiens)
SRP:polypeptide+signal:ribosome [cytosol] (Homo sapiens)
ribosome:mRNA:polypeptide+signal [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
ribosome:mRNA:polypeptide+signal [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein (Homo sapiens)
cleaved polypeptide:Translocon [endoplasmic reticulum membrane] (Homo sapiens)
membrane-bound ribosome:mRNA:cleaved polypeptide [endoplasmic reticulum membrane] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
polypeptide+signal:Translocon [endoplasmic reticulum membrane] (Homo sapiens)
membrane-bound ribosome:mRNA:polypeptide+signal [endoplasmic reticulum membrane] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
Signal-containing nascent peptide translocates to endoplasmic reticulum (Homo sapiens)
SRP receptor:SRP:ribosome:polypeptide+signal [endoplasmic reticulum membrane] (Homo sapiens)
SRP:polypeptide+signal:ribosome [cytosol] (Homo sapiens)
ribosome:mRNA:polypeptide+signal [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
polypeptide+signal:Translocon [endoplasmic reticulum membrane] (Homo sapiens)
membrane-bound ribosome:mRNA:polypeptide+signal [endoplasmic reticulum membrane] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
Synthesis of nascent polypeptide containing signal sequence (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
ribosome:mRNA:polypeptide+signal [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
The SRP receptor binds the SRP:nascent peptide:ribosome complex (Homo sapiens)
SRP receptor:SRP:ribosome:polypeptide+signal [endoplasmic reticulum membrane] (Homo sapiens)
SRP:polypeptide+signal:ribosome [cytosol] (Homo sapiens)
ribosome:mRNA:polypeptide+signal [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
SRP:polypeptide+signal:ribosome [cytosol] (Homo sapiens)
ribosome:mRNA:polypeptide+signal [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P23396 RPS3
Gene Names
RPS3, OK/SW-cl.26
Chain
initiator methionine:, chain:2-243
Reference Genes
BioGPS Gene:6188 RPS3
COSMIC (genes):RPS3 RPS3
CTD Gene:6188 RPS3
dbSNP Gene:6188 RPS3
ENSEMBL:ENSG00000149273 RPS3
ENSEMBL_homo_sapiens_GENE:ENSG00000149273.15 RPS3
HGNC:10420 RPS3
KEGG Gene (Homo sapiens):6188 RPS3
Monarch:6188 RPS3
NCBI Gene:6188 RPS3
OMIM:600454 RPS3
UCSC:P23396 RPS3
Reference Transcript
RefSeq:NM_001256802.1 RPS3
RefSeq:NM_001005.4 RPS3
RefSeq:NM_001260507.1 RPS3
RefSeq:NM_001260506.1 RPS3
Other Identifiers
11757264_s_at
16729103
208692_PM_at
208692_at
214208_at
2940643
2940649
3340547
3340552
3340553
3340554
3340555
3340557
3340558
3340559
3340560
3340561
3340562
3340565
3340566
3340567
3340568
3340569
3340570
3340571
3340572
3340577
34645_at
6188
63493_at
7942586
A_14_P112056
A_23_P139376
A_24_P218765
GE79155
GE84158
GO:0000977
GO:0002181
GO:0002376
GO:0003677
GO:0003684
GO:0003723
GO:0003729
GO:0003735
GO:0003824
GO:0003906
GO:0004520
GO:0005198
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005739
GO:0005743
GO:0005759
GO:0005783
GO:0005819
GO:0005829
GO:0005840
GO:0005856
GO:0005886
GO:0005925
GO:0006281
GO:0006284
GO:0006351
GO:0006355
GO:0006412
GO:0006413
GO:0006417
GO:0006915
GO:0006974
GO:0007010
GO:0007049
GO:0007059
GO:0007155
GO:0008017
GO:0008092
GO:0010628
GO:0012501
GO:0014069
GO:0015631
GO:0015935
GO:0016020
GO:0016787
GO:0016829
GO:0017148
GO:0019899
GO:0019900
GO:0019901
GO:0022626
GO:0022627
GO:0023052
GO:0030544
GO:0031116
GO:0031334
GO:0031397
GO:0032079
GO:0032357
GO:0032358
GO:0032587
GO:0032743
GO:0034614
GO:0036211
GO:0042104
GO:0042981
GO:0043226
GO:0043507
GO:0044390
GO:0044877
GO:0045738
GO:0045739
GO:0050862
GO:0051018
GO:0051092
GO:0051225
GO:0051301
GO:0051536
GO:0051879
GO:0061481
GO:0065003
GO:0070062
GO:0070181
GO:0070301
GO:0071159
GO:0071356
GO:0072686
GO:0097100
GO:0140078
GO:0140097
GO:0140297
GO:1901224
GO:1902231
GO:1905053
GO:1990904
GO:2001235
GO:2001272
HMNXSV003045985
Hs.59728.0.A1_3p_at
TC11000806.hg
X55715_at
g555940_3p_at
Participates
as a component of
40S ribosomal complex [cytosol] (Homo sapiens)
Other forms of this molecule
RPS3 [nucleoplasm]
Inferred To
Rps3 [cytosol]
(Mus musculus)
Rps3 [cytosol]
(Rattus norvegicus)
Homologues of RPS3 [cytosol]
(Sus scrofa)
RPS3 [cytosol]
(Bos taurus)
RPS3 [cytosol]
(Canis familiaris)
RPS3 [cytosol]
(Gallus gallus)
RPS3 [cytosol]
(Plasmodium falciparum)
RPS3 [cytosol]
(Saccharomyces cerevisiae)
RPS3 [cytosol]
(Sus scrofa)
RpS3 [cytosol]
(Drosophila melanogaster)
rps3 [cytosol]
(Danio rerio)
rps3 [cytosol]
(Dictyostelium discoideum)
rps3 [cytosol]
(Schizosaccharomyces pombe)
rps3 [cytosol]
(Xenopus tropicalis)
rps-3 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001243731.1
,
NP_000996.2
,
NP_001247435.1
,
NP_001247436.1
OpenTargets
ENSG00000149273
IntEnz
4.2.99.18
HPA
ENSG00000149273-RPS3
GeneCards
P23396
Ensembl
ENST00000278572
,
ENST00000527446
,
ENSP00000433821
,
ENSG00000149273
,
ENSP00000278572
,
ENSP00000436971
,
ENSP00000434643
,
ENST00000531188
,
ENST00000524851
PRO
P23396
Pharos - Targets
P23396
PDB
6Y0G
,
6OLZ
,
6OM0
,
6QZP
,
5OA3
,
6OM7
,
5A2Q
,
8JDJ
,
5T2C
,
5LKS
,
6Z6L
,
6Y57
,
8JDK
,
8T4S
,
6Z6M
,
8JDL
,
6OLF
,
6G5H
,
8PPL
,
6IP5
,
7A09
,
6Z6N
,
6ZON
,
6ZXE
,
6ZN5
,
6ZVJ
,
7QP7
,
6ZMW
,
6OLG
,
7QP6
,
1WH9
,
8IFD
,
8G6J
,
6ZXF
,
8GLP
,
7XNX
,
6ZP4
,
6FEC
,
4UG0
,
6ZMI
,
6ZV6
,
8G5Y
,
5AJ0
,
6Y2L
,
6ZXH
,
6YBS
,
8G60
,
7QVP
,
6G53
,
8JDM
,
8G5Z
,
8PPK
,
6ZMO
,
5VYC
,
8G61
,
6OLE
,
6ZMT
,
6ZVH
,
4V6X
,
7K5I
,
6ZOJ
,
6ZLW
,
6ZXD
,
8Y0W
,
6ZM7
,
6ZOL
,
6XA1
,
6G5I
,
6ZUO
,
6OLI
,
5FLX
,
8IFE
,
6IP6
,
8Y0X
,
6ZXG
,
7XNY
,
6ZME
,
6IP8
,
7TQL
,
7R4X
,
8OZ0
,
6G51
Interactors (26)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q04206 RELA
7
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
p-S536-RELA [nucleoplasm]
(R-HSA-9861499)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
RELA [cytosol]
(R-HSA-168172)
RELA [nucleoplasm]
(R-HSA-177676)
0.797
8
UniProt:P63244 RACK1
1
GNB2L1 [cytosol]
(R-HSA-5626956)
0.787
5
UniProt:Q96GA3 LTV1
2
LTV1 [nucleoplasm]
(R-HSA-6791566)
LTV1 [cytosol]
(R-HSA-6791520)
0.737
5
UniProt:Q13895 BYSL
2
BYSL [nucleoplasm]
(R-HSA-6791526)
BYSL [cytosol]
(R-HSA-6791518)
0.706
4
UniProt:Q00987 MDM2
11
PolyUb-MDM2 [nucleoplasm]
(R-HSA-6782472)
monoSUMO1-K182-MDM2 [nucleoplasm]
(R-HSA-3000408)
MDM2 [plasma membrane]
(R-HSA-416843)
MDM2 [endocytic vesicle membrane]
(R-HSA-416849)
p-5S,T-MDM2 [nucleoplasm]
(R-HSA-6804954)
PolyUb,p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6795669)
p-S166,S188,T218-MDM2 [nucleoplasm]
(R-HSA-6792862)
MDM2 [nucleoplasm]
(R-HSA-69486)
MDM2 [cytosol]
(R-HSA-198644)
p-S166,S188-MDM2 [cytosol]
(R-HSA-198638)
p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6793669)
0.686
8
UniProt:P25963 NFKBIA
9
PolyUb-NFKBIA [cytosol]
(R-HSA-6782960)
NFKBIA [cytosol]
(R-HSA-168151)
p-S32,S36-NFKBIA [cytosol]
(R-HSA-177677)
Ub-K21,22-p-S32,S36-NFKBIA [cytosol]
(R-HSA-1168581)
NFKBIA [nucleoplasm]
(R-HSA-4656929)
monoSUMO1-K21-NFKBIA [nucleoplasm]
(R-HSA-4656935)
NFKBIA S32I [cytosol]
(R-HSA-5228846)
NFKBIA F2_M37del [cytosol]
(R-HSA-9630119)
NFKBIA M37K [cytosol]
(R-HSA-5228805)
0.677
6
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.643
6
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.642
4
UniProt:P19838 NFKB1
8
NFKB1(1-968) [specific granule lumen]
(R-HSA-6799557)
NFKB1(1-968) [extracellular region]
(R-HSA-6806304)
NFKB1(1-968) [secretory granule lumen]
(R-HSA-6801004)
NFKB1(1-433) [cytosol]
(R-HSA-168168)
NFKB1(1-433) [nucleoplasm]
(R-HSA-177655)
NFKB1(1-968) [cytosol]
(R-HSA-451607)
p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451611)
3xUb-p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451619)
0.623
5
UniProt:Q15843 NEDD8
8
C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm]
(R-HSA-8952504)
NEDD8 [nucleoplasm]
(R-HSA-8955926)
C116-AcM-UBE2F-G76-NEDD8 [cytosol]
(R-HSA-8951739)
NEDD8(77-81) [cytosol]
(R-HSA-6782654)
NEDD8(1-81) [cytosol]
(R-HSA-5690794)
C237-UBA3-G76-NEDD8 [cytosol]
(R-HSA-8951647)
NEDD8 [cytosol]
(R-HSA-416969)
C111-AcM-UBE2M-G76-NEDD8 [cytosol]
(R-HSA-4419895)
0.623
3
UniProt:O14920 IKBKB
3
IKBKB Q432Pfs*62 [cytosol]
(R-HSA-9628518)
IKBKB [cytosol]
(R-HSA-168114)
p-S177,S181-IKBKB [cytosol]
(R-HSA-202506)
0.602
4
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.59
4
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.564
2
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:Q2NL82 TSR1
2
TSR1 [nucleoplasm]
(R-HSA-6791574)
TSR1 [cytosol]
(R-HSA-6791570)
0.527
2
UniProt:Q01523 DEFA5
5
DEFA5(1-94) [Golgi lumen]
(R-HSA-1467267)
DEFA5(20-94) [Golgi lumen]
(R-HSA-1467208)
DEFA5(20-94) [secretory granule lumen]
(R-HSA-1471358)
DEFA5(20-94) [extracellular region]
(R-HSA-1471344)
DEFA5(?-94) [extracellular region]
(R-HSA-1462017)
0.527
2
UniProt:Q8TBF4 ZCRB1
2
ZCRB1 [cytosol]
(R-HSA-9682010)
ZCRB1 [nucleoplasm]
(R-HSA-6787853)
0.527
2
UniProt:P16104 H2AFX
7
Me2sR4-H2AFX [nucleoplasm]
(R-HSA-5218317)
H2AFX [nucleoplasm]
(R-HSA-56151)
p-Y143-H2AFX [nucleoplasm]
(R-HSA-5683942)
p-S140,Y143-H2AFX [nucleoplasm]
(R-HSA-5683953)
p-S140-H2AFX [nucleoplasm]
(R-HSA-75170)
K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm]
(R-HSA-5682847)
H2AFX [extracellular region]
(R-HSA-977583)
0.527
3
UniProt:P62249 RPS16
2
RPS16 [nucleoplasm]
(R-HSA-6791196)
RPS16 [cytosol]
(R-HSA-72337)
0.527
3
UniProt:P15880 RPS2
3
RPS2 [nucleoplasm]
(R-HSA-6790655)
Me2aR-RPS2 [cytosol]
(R-HSA-8879138)
RPS2 [cytosol]
(R-HSA-72347)
0.527
3
UniProt:Q9NR30 DDX21
1
DDX21 [nucleoplasm]
(R-HSA-5250652)
0.483
2
UniProt:Q00341 HDLBP
1
HDLBP [plasma membrane]
(R-HSA-8858026)
0.483
2
UniProt:Q5VYS8 ZCCHC6
1
TUT7 [cytosol]
(R-HSA-8941313)
0.483
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
12
UniProt:Q9UKV8 AGO2
2
AGO2 [nucleoplasm]
(R-HSA-5578701)
AGO2 [cytosol]
(R-HSA-209723)
0.483
3
UniProt:P47756 CAPZB
1
CAPZB [cytosol]
(R-HSA-879409)
0.483
2
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