Reactome | RPS7 [cytosol]

RPS7 [cytosol]

Stable Identifier

R-HSA-72383

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

40S small ribosomal protein 7, P23821, 40S ribosomal protein S7, S8

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to starvation (Homo sapiens)
    - Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
      - EIF2AK4 (GCN2) binds tRNA (Homo sapiens)
        
        EIF2AK4:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS7 [cytosol] (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS7 [cytosol] (Homo sapiens)
      - EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS7 [cytosol] (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS7 [cytosol] (Homo sapiens)
      - IMPACT binds GCN1 (Homo sapiens)
        
        GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS7 [cytosol] (Homo sapiens)
        
        IMPACT:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS7 [cytosol] (Homo sapiens)
      - p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS7 [cytosol] (Homo sapiens)

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Signaling by ROBO receptors (Homo sapiens)
      - Regulation of expression of SLITs and ROBOs (Homo sapiens)
        
        Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS7 [cytosol] (Homo sapiens)
        
        Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS7 [cytosol] (Homo sapiens)
        
        Translation of ROBO3.2 mRNA is negatively regulated by NMD (Homo sapiens)
        
        Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS7 [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS7 [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS7 [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS7 [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS7 [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS7 [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS7 [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS7 [cytosol] (Homo sapiens)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS7 [cytosol] (Homo sapiens)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS7 [cytosol] (Homo sapiens)
- rRNA processing (Homo sapiens)
  - rRNA processing in the nucleus and cytosol (Homo sapiens)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
      - 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS7 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62081 RPS7

Gene Names

RPS7

Chain

chain:1-194

Reference Genes

BioGPS Gene:6201 RPS7

COSMIC (genes):RPS7 RPS7

CTD Gene:6201 RPS7

dbSNP Gene:6201 RPS7

ENSEMBL:ENSG00000171863 RPS7

ENSEMBL_homo_sapiens_GENE:ENSG00000171863.15 RPS7

HGNC:10440 RPS7

KEGG Gene (Homo sapiens):6201 RPS7

Monarch:6201 RPS7

NCBI Gene:6201 RPS7

OMIM:603658 RPS7

UCSC:P62081 RPS7

Reference Transcript

RefSeq:NM_001011.3 RPS7

Other Identifiers

11717235_s_at

11717236_x_at

18670223

18670224

18670225

18670227

200082_PM_s_at

200082_s_at

213941_PM_x_at

213941_x_at

2467184

2467185

2467186

2467187

2467188

2467189

2467191

2467192

2467196

2467200

2467201

2467205

34646_at

3715611

3715612

3715613

3760488

6201

7892643

7894978

7895808

7896137

8040036

A_23_P141549

GE79310

GO:0001843

GO:0002181

GO:0003723

GO:0003730

GO:0003735

GO:0005198

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005783

GO:0005813

GO:0005815

GO:0005829

GO:0005840

GO:0005856

GO:0005925

GO:0006364

GO:0006412

GO:0010628

GO:0012501

GO:0014033

GO:0016020

GO:0019901

GO:0022626

GO:0022627

GO:0023052

GO:0030154

GO:0030163

GO:0032040

GO:0032991

GO:0036211

GO:0042254

GO:0042274

GO:0043226

GO:0045202

GO:0048027

GO:0048856

GO:0050821

GO:0098772

GO:1902255

GO:1904667

GO:1990904

GO:1990948

GO:2000059

HMNXSV003015427

Hs.301547.2.S1_3p_x_at

Hs.301547.3.A1_3p_a_at

ILMN_1750722

ILMN_2070072

Z25749_rna1_at

Participates

as a component of

40S ribosomal complex [cytosol] (Homo sapiens)

Other forms of this molecule

RPS7 [nucleoplasm]

Inferred To

RPS7A [cytosol] (Saccharomyces cerevisiae)

Rps7 [cytosol] (Mus musculus)

Rps7 [cytosol] (Rattus norvegicus)

RPS7 [cytosol] (Bos taurus)

RPS7 [cytosol] (Canis familiaris)

RPS7 [cytosol] (Gallus gallus)

RPS7 [cytosol] (Plasmodium falciparum)

RPS7 [cytosol] (Sus scrofa)

rps7 [cytosol] (Danio rerio)

rps7 [cytosol] (Dictyostelium discoideum)

rps7 [cytosol] (Schizosaccharomyces pombe)

rps-7 [cytosol] (Caenorhabditis elegans)

Homologues of RPS7 [cytosol] (Rattus norvegicus)

Ghost homologue of RPS7 [cytosol] (Xenopus tropicalis)

RpS7 [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_001002.1

OpenTargets

ENSG00000171863

HPA

ENSG00000171863-RPS7

GeneCards

P62081

Ensembl

ENSP00000385018, ENST00000646909, ENST00000645674, ENST00000403564, ENST00000462576, ENSP00000495273, ENSP00000496757, ENST00000406376, ENSG00000171863, ENSP00000496654, ENSP00000385286

PRO

P62081

Pharos - Targets

P62081

Orphanet

17891

PDB

4UG0, 8T4S, 7WU0, 5AJ0, 7MQA, 6YBW, 6OLG, 6FEC, 7WTW, 7WTV, 8G5Z, 5A2Q, 6OM7, 7MQ8, 7TQL, 6ZXH, 7R4X, 6Y2L, 6ZXD, 5FLX, 7QP6, 6ZON, 6ZXF, 8IFE, 4V6X, 6ZMW, 8G6J, 6ZOJ, 8PPL, 6G4W, 6ZOK, 8IFD, 6IP8, 6XA1, 6Z6N, 6G5H, 5OA3, 7K5I, 8PPK, 6G18, 6Z6M, 5T2C, 6ZMT, 5LKS, 6G4S, 7WTZ, 8JDM, 6ZLW, 6G5I, 7WTX, 6OLF, 6ZMO, 8JDL, 6OLE, 6Y57, 8G61, 6ZV6, 6Z6L, 8JDK, 7MQ9, 8G60, 6ZMI, 6G53, 8G5Y, 8JDJ, 6ZP4, 6OLZ, 6ZUO, 7WTU, 6ZXE, 6ZME, 6ZXG, 7QP7, 5VYC, 6ZVH, 7WTT, 8OZ0, 6ZVJ, 8Y0X, 7XNY, 6QZP, 7WTS, 6ZN5, 6G51, 8Y0W, 6YBD, 6Y0G, 7XNX, 6OM0, 7A09, 6IP5, 6OLI, 6ZM7, 8GLP, 6IP6

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q00987 MDM2	11	PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.817	17
UniProt:O43829 ZBT14			0.666	4
UniProt:P46777 RPL5	1	RPL5 [cytosol] (R-HSA-72482)	0.643	3
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.638	3
UniProt:P13693 TCTP			0.527	2
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.527	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	6
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739) NEDD8(77-81) [cytosol] (R-HSA-6782654) NEDD8(1-81) [cytosol] (R-HSA-5690794) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8 [cytosol] (R-HSA-416969) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895)	0.499	2

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