Reactome | RPSA [cytosol]

RPSA [cytosol]

Stable Identifier

R-HSA-72389

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

40S small ribosomal protein P4, P08865, 40S ribosomal protein SA, P40, 34/67 kDa laminin receptor, Colon carcinoma laminin-binding protein, NEM/1CHD4, Multidrug resistance- associated protein MGr1-Ag

Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to starvation (Homo sapiens)
    - Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
      - EIF2AK4 (GCN2) binds tRNA (Homo sapiens)
        
        EIF2AK4:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPSA [cytosol] (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPSA [cytosol] (Homo sapiens)
      - EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPSA [cytosol] (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPSA [cytosol] (Homo sapiens)
      - IMPACT binds GCN1 (Homo sapiens)
        
        GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPSA [cytosol] (Homo sapiens)
        
        IMPACT:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPSA [cytosol] (Homo sapiens)
      - p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPSA [cytosol] (Homo sapiens)

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Signaling by ROBO receptors (Homo sapiens)
      - Regulation of expression of SLITs and ROBOs (Homo sapiens)
        
        Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPSA [cytosol] (Homo sapiens)
        
        Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPSA [cytosol] (Homo sapiens)
        
        Translation of ROBO3.2 mRNA is negatively regulated by NMD (Homo sapiens)
        
        Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPSA [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPSA [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPSA [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPSA [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPSA [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPSA [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPSA [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPSA [cytosol] (Homo sapiens)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPSA [cytosol] (Homo sapiens)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPSA [cytosol] (Homo sapiens)
- rRNA processing (Homo sapiens)
  - rRNA processing in the nucleus and cytosol (Homo sapiens)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
      - 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPSA [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P08865 RPSA

Gene Names

RPSA, LAMBR, LAMR1

Chain

initiator methionine:, chain:2-295

Reference Genes

BioGPS Gene:3921 RPSA

COSMIC (genes):RPSA RPSA

CTD Gene:3921 RPSA

dbSNP Gene:3921 RPSA

ENSEMBL:ENSG00000168028 RPSA

ENSEMBL_homo_sapiens_GENE:ENSG00000168028.15 RPSA

HGNC:6502 RPSA

KEGG Gene (Homo sapiens):3921 RPSA

Monarch:3921 RPSA

NCBI Gene:3921 RPSA

OMIM:150370 RPSA

UCSC:P08865 RPSA

Reference Transcript

Other Identifiers

11757305_x_at

213801_PM_x_at

213801_x_at

2425627

2425629

2425631

2425633

2425635

2425637

2425641

2425643

2425645

2436651

2436653

2440102

2440114

2440116

2484817

2484822

2484823

256_s_at

2615859

2618292

2618294

2618298

2618306

2618312

2618314

2618316

2618326

2618328

2618330

2618334

2618336

2618338

2688367

2713125

2733277

2745643

2970250

3064526

3104760

3175476

3175481

3175487

3175491

3178398

3461268

3480591

3480593

3480594

3480599

3516848

3549854

3827228

3827230

3827231

3827233

3827234

3827235

3827236

3827237

3921

3975436

3975438

3981817

4014396

4014397

4014399

4014402

4014403

59681_at

7918050

8078905

A_21_P0010639

A_23_P254415

GE80131

GO:0000028

GO:0001618

GO:0002181

GO:0003723

GO:0003735

GO:0005055

GO:0005198

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005840

GO:0005886

GO:0006412

GO:0007155

GO:0015935

GO:0016020

GO:0022626

GO:0022627

GO:0042254

GO:0043022

GO:0043226

GO:0043236

GO:0046718

GO:0065003

GO:0070062

GO:0098631

GO:1990904

HMNXSV003035555

Hs.181357.2.A1_3p_x_at

ILMN_1664910

ILMN_2411723

M14199_s_at

PH_hs_0029924

PH_hs_0035860

TC01005671.hg

U43901_rna1_s_at

Participates

as a component of

40S ribosomal complex [cytosol] (Homo sapiens)

Other forms of this molecule

RPSA [nucleoplasm]

Inferred To

rps-0 [cytosol] (Caenorhabditis elegans)

RPS0A [cytosol] (Saccharomyces cerevisiae)

rps001 [cytosol] (Schizosaccharomyces pombe)

rpsa [cytosol] (Danio rerio)

rpsa [cytosol] (Xenopus tropicalis)

rpsA [cytosol] (Dictyostelium discoideum)

RPSA [cytosol] (Bos taurus)

RPSA [cytosol] (Canis familiaris)

RPSA [cytosol] (Gallus gallus)

RPSA [cytosol] (Plasmodium falciparum)

RPSA [cytosol] (Sus scrofa)

sta [cytosol] (Drosophila melanogaster)

Rpsa [cytosol] (Mus musculus)

Rpsa [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_002286.2, NP_001291217.1

OpenTargets

ENSG00000168028

HPA

ENSG00000168028-RPSA

GeneCards

P08865

Ensembl

ENST00000458478, ENST00000697729, ENSP00000513423, ENSP00000410848, ENSP00000513424, ENSP00000513425, ENSG00000168028, ENST00000697731, ENST00000697730, ENSP00000346067, ENST00000301821

PRO

P08865

Pharos - Targets

P08865

Orphanet

22218

PDB

7TQL, 6ZMW, 8PPL, 6ZOK, 6Z6N, 5A2Q, 7A09, 6Z6L, 8IFD, 6OLF, 8G61, 6ZLW, 6ZVH, 8G5Z, 6OLG, 8OZ0, 6XA1, 5AJ0, 6IP8, 6G5I, 6YBD, 6QZP, 6ZON, 6OLI, 5FLX, 6G5H, 6IP6, 6Y0G, 7R4X, 6OM7, 6FEC, 8JDK, 7QVP, 6ZP4, 8G6J, 8JDL, 8T4S, 6ZMO, 4V6X, 6Y57, 7WTX, 6ZN5, 7QP7, 8Y0X, 6ZM7, 6ZXD, 6ZVJ, 6ZOJ, 7K5I, 7QP6, 7WTW, 4UG0, 6ZMT, 6Z6M, 7WTV, 6ZUO, 6ZXG, 6OM0, 6Y2L, 8GLP, 8JDM, 7WTZ, 6ZXF, 6ZXE, 6IP5, 8PPK, 7WU0, 8Y0W, 7XNY, 5OA3, 6G4S, 6ZV6, 6ZMI, 6ZXH, 7XNX, 3BCH, 6OLZ, 6ZME, 5LKS, 5VYC, 6OLE, 8IFE, 6G53, 8G60, 8G5Y, 6YBW, 6G18, 6G51, 5T2C, 8JDJ

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.666	4
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.638	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P00441 SOD1	5	SOD1 [extracellular region] (R-HSA-350705) 2xHC-SOD1 [mitochondrial intermembrane space] (R-HSA-3777108) SOD1 [mitochondrial intermembrane space] (R-HSA-3777082) 2xHC-SOD1 [cytosol] (R-HSA-3299726) SOD1 [cytosol] (R-HSA-350697)	0.556	3
UniProt:Q9UQC2 GAB2	5	p-Y643-GAB2 [cytosol] (R-HSA-9677149) p-5Y-GAB2 [cytosol] (R-HSA-8855574) p-Y-GAB2 [cytosol] (R-HSA-912529) p-Y452,Y476,Y584-GAB2 [cytosol] (R-HSA-2685615) GAB2 [cytosol] (R-HSA-508239)	0.556	3
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.527	3
UniProt:Q2NL82 TSR1	2	TSR1 [nucleoplasm] (R-HSA-6791574) TSR1 [cytosol] (R-HSA-6791570)	0.527	2
UniProt:Q8TBF4 ZCRB1	2	ZCRB1 [cytosol] (R-HSA-9682010) ZCRB1 [nucleoplasm] (R-HSA-6787853)	0.527	3
UniProt:P62979 RPS27A	20	RPS27A(1-76) [endocytic vesicle membrane] (R-HSA-939208) RPS27A(77-156) [nucleoplasm] (R-HSA-6798734) Ub-33-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783024) Ub-63-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783200) Ub-6-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783040) Ub-11-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783085) Ub-48-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783075) Ub-29-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783146) Ub-27-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783176) N6-glycyl-L-lysine-RPS27A(1-76) [cytosol] (R-HSA-8869045) adenylatedlG76-RPS27A(1-76) [nucleoplasm] (R-HSA-8852078) RPS27A [cytosol] (R-HSA-8853524) adenylatedlG76-RPS27A(1-76) [cytosol] (R-HSA-8852065) Ub-48-RPS27A(1-76) [endoplasmic reticulum membrane] (R-HSA-8943102) Ub-48-RPS27A(1-76) [lysosomal membrane] (R-HSA-9763033) Ub-48-RPS27A(1-76) [endocytic vesicle membrane] (R-HSA-9763012) RPS27A(1-76) [endosome membrane] (R-HSA-939238) RPS27A(1-76) [plasma membrane] (R-HSA-3149457) Ub-29-RPS27A(1-76) [cytosol] (R-HSA-5689223) Ub-6-RPS27A(1-76) [cytosol] (R-HSA-5689098)	0.527	2
UniProt:O60832 DKC1	1	DKC1 [nucleoplasm] (R-HSA-163102)	0.527	2
UniProt:P62249 RPS16	2	RPS16 [nucleoplasm] (R-HSA-6791196) RPS16 [cytosol] (R-HSA-72337)	0.527	2
UniProt:P05455 SSB	1	SSB [nucleoplasm] (R-HSA-58418)	0.527	2
UniProt:P15880 RPS2	3	RPS2 [nucleoplasm] (R-HSA-6790655) Me2aR-RPS2 [cytosol] (R-HSA-8879138) RPS2 [cytosol] (R-HSA-72347)	0.527	3
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.527	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	12

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