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What is Reactome ?
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Digital Preservation
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Table of Contents
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RPL22 [cytosol]
Stable Identifier
R-HSA-72428
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
60S ribosomal protein L22, Epstein-Barr virus small RNA associated protein, EBER associated protein, EAP, Heparin binding protein HBp15
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to starvation (Homo sapiens)
Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
EIF2AK4 (GCN2) binds tRNA (Homo sapiens)
EIF2AK4:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)
tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
IMPACT binds GCN1 (Homo sapiens)
GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
IMPACT:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
Regulation of expression of SLITs and ROBOs (Homo sapiens)
Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
Translation of ROBO3.2 mRNA is negatively regulated by NMD (Homo sapiens)
Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Influenza Infection (Homo sapiens)
Influenza Viral RNA Transcription and Replication (Homo sapiens)
Viral mRNA Translation (Homo sapiens)
Synthesis of PB1-F2 (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
Viral Protein Synthesis (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Selenoamino acid metabolism (Homo sapiens)
Selenocysteine synthesis (Homo sapiens)
80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC (Homo sapiens)
80S:Met-tRNAi:mRNA:SECISBP2:Sec [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
Sec-tRNA(Sec):EEFSEC:GTP binds to 80S Ribosome (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Nonsense-Mediated Decay (NMD) (Homo sapiens)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
rRNA processing (Homo sapiens)
rRNA processing in the nucleus and cytosol (Homo sapiens)
Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Elongation (Homo sapiens)
Peptide chain elongation (Homo sapiens)
Aminoacyl-tRNA binds to the ribosome at the A-site (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
80S:aminoacyl tRNA:mRNA:eEF1A:GTP [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
Hydrolysis of eEF1A:GTP (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA:aminoacyl-tRNA [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
80S:aminoacyl tRNA:mRNA:eEF1A:GTP [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
Peptide transfer from P-site tRNA to the A-site tRNA (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA:aminoacyl-tRNA [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
Elongation complex with growing peptide chain [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
Translocation of ribosome by 3 bases in the 3' direction (Homo sapiens)
80S Ribosome:mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
Elongation complex with growing peptide chain [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
Formation of a pool of free 40S subunits (Homo sapiens)
Release of 40S and 60S subunits from the 80S ribosome (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
GTP hydrolysis and joining of the 60S ribosomal subunit (Homo sapiens)
The 60S subunit joins the translation initiation complex (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
eIF5B:GTP is hydrolyzed and released (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
L13a-mediated translational silencing of Ceruloplasmin expression (Homo sapiens)
Dissociation of L13a from the 60s ribosomal subunit (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
60s ribosomal complex lacking L13a subunit [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
Eukaryotic Translation Termination (Homo sapiens)
GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex (Homo sapiens)
Me-Q185-ETF1 dimer:eRF3:GDP:80S Ribosome:mRNA:peptidyl-tRNA Complex [cytosol] (Homo sapiens)
80S Ribosome:mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
Me-Q185-ETF1 dimer:eRF3:GTP:80S Ribosome:mRNA:peptidyl-tRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex (Homo sapiens)
80S Ribosome:mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
Me-Q185-ETF1 dimer:eRF3:GTP:80S Ribosome:mRNA:peptidyl-tRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex (Homo sapiens)
Me-Q185-ETF1 dimer:eRF3:GDP:80S Ribosome:mRNA:peptidyl-tRNA Complex [cytosol] (Homo sapiens)
80S Ribosome:mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
Me-Q185-ETF1 dimer:eRF3:GDP:80S Ribosome:mRNA:tRNA Complex [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
SRP-dependent cotranslational protein targeting to membrane (Homo sapiens)
Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Homo sapiens)
SRP:polypeptide+signal:ribosome [cytosol] (Homo sapiens)
ribosome:mRNA:polypeptide+signal [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
ribosome:mRNA:polypeptide+signal [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein (Homo sapiens)
cleaved polypeptide:Translocon [endoplasmic reticulum membrane] (Homo sapiens)
membrane-bound ribosome:mRNA:cleaved polypeptide [endoplasmic reticulum membrane] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
polypeptide+signal:Translocon [endoplasmic reticulum membrane] (Homo sapiens)
membrane-bound ribosome:mRNA:polypeptide+signal [endoplasmic reticulum membrane] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
Signal-containing nascent peptide translocates to endoplasmic reticulum (Homo sapiens)
SRP receptor:SRP:ribosome:polypeptide+signal [endoplasmic reticulum membrane] (Homo sapiens)
SRP:polypeptide+signal:ribosome [cytosol] (Homo sapiens)
ribosome:mRNA:polypeptide+signal [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
polypeptide+signal:Translocon [endoplasmic reticulum membrane] (Homo sapiens)
membrane-bound ribosome:mRNA:polypeptide+signal [endoplasmic reticulum membrane] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
Synthesis of nascent polypeptide containing signal sequence (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
ribosome:mRNA:polypeptide+signal [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
The SRP receptor binds the SRP:nascent peptide:ribosome complex (Homo sapiens)
SRP receptor:SRP:ribosome:polypeptide+signal [endoplasmic reticulum membrane] (Homo sapiens)
SRP:polypeptide+signal:ribosome [cytosol] (Homo sapiens)
ribosome:mRNA:polypeptide+signal [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
SRP:polypeptide+signal:ribosome [cytosol] (Homo sapiens)
ribosome:mRNA:polypeptide+signal [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
60S ribosomal complex [cytosol] (Homo sapiens)
RPL22,RPL22L1 [cytosol] (Homo sapiens)
RPL22 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35268 RPL22
Gene Names
RPL22
Chain
initiator methionine:, chain:2-128
Reference Genes
BioGPS Gene:6146 RPL22
COSMIC (genes):RPL22 RPL22
CTD Gene:6146 RPL22
dbSNP Gene:6146 RPL22
ENSEMBL:ENSG00000116251 RPL22
HGNC:10315 RPL22
KEGG:hsa:6146 RPL22
Monarch:6146 RPL22
NCBI Gene:6146 RPL22
OMIM:180474 RPL22
UCSC:P35268 RPL22
Reference Transcript
RefSeq:NM_000983.3 RPL22
Other Identifiers
1151_at
11728658_s_at
11757489_x_at
11757784_s_at
208768_3p_x_at
208768_PM_x_at
208768_x_at
214042_3p_s_at
214042_PM_s_at
214042_s_at
220960_3p_x_at
220960_PM_x_at
220960_x_at
221726_PM_at
221726_at
221775_3p_x_at
221775_PM_x_at
221775_x_at
2394560
2394561
2394562
2394563
2394564
2394565
2394566
2394567
2394568
2394569
2394570
2394571
2394572
2394573
2394574
2394575
2394576
2394577
2498357
2500117
2704549
2704550
2704551
2704552
2704553
2704554
3036536
33451_s_at
3572827
4003352
6146
64330_s_at
65984_at
74718_at
7911989
A_23_P115460
A_24_P849801
GE86039
GO:0002181
GO:0002376
GO:0003723
GO:0003735
GO:0005198
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0005840
GO:0005925
GO:0006412
GO:0008201
GO:0022625
GO:0022626
GO:0030154
GO:0042802
GO:0043226
GO:0045202
GO:0046632
GO:0070062
GO:0098793
GO:0098978
GO:0140236
GO:1990904
HMNXSV003039849
Hs.326249.0.A1_3p_s_at
Hs.326249.1.A2_3p_at
Hs.99914.2.S1_3p_s_at
ILMN_1732328
ILMN_2079386
PH_hs_0029744
PH_hs_0032674
g400340_3p_s_at
g400340_3p_x_at
g409069_3p_s_at
g4506612_3p_s_at
Participates
as a member of
RPL22,RPL22L1 [cytosol] (Homo sapiens)
Inferred To
RPL22 [cytosol]
(Bos taurus)
RPL22 [cytosol]
(Canis familiaris)
RPL22 [cytosol]
(Gallus gallus)
RPL22 [cytosol]
(Plasmodium falciparum)
RPL22 [cytosol]
(Sus scrofa)
Homologues of RPL22 [cytosol]
(Drosophila melanogaster)
Rpl22 [cytosol]
(Mus musculus)
Rpl22 [cytosol]
(Rattus norvegicus)
RpL22 [cytosol]
(Drosophila melanogaster)
rpl22 [cytosol]
(Danio rerio)
rpl22 [cytosol]
(Xenopus tropicalis)
RpL22-like [cytosol]
(Drosophila melanogaster)
rpl-22 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_000974.1
OpenTargets
ENSG00000116251
ENSEMBL
ENSP00000346088
,
ENST00000234875
HPA
ENSG00000116251-RPL22
PRO
P35268
Pharos - Targets
P35268
GlyGen
P35268
HMDB Protein
HMDBP10729
PDB
8IDT
,
6IP5
,
8IR1
,
6ZM7
,
6IP8
,
8FL7
,
8FL4
,
6ZME
,
8FL2
,
6Y57
,
8OJ0
,
5T2C
,
6LU8
,
4UG0
,
8IPX
,
8OHD
,
6OM7
,
8IE3
,
8INE
,
6OLF
,
7XNX
,
8OJ5
,
6OLE
,
8JDJ
,
8JDL
,
8QOI
,
8G60
,
8A3D
,
8Y0X
,
8FLA
,
6Y0G
,
7QVP
,
6OM0
,
6Y6X
,
8QFD
,
6OLI
,
6Z6N
,
8IFD
,
6ZMO
,
8FLE
,
8OJ8
,
8IDY
,
6IP6
,
8FL9
,
8IR3
,
8FL6
,
7F5S
,
6LQM
,
6Y2L
,
6W6L
,
8FKZ
,
8FL3
,
8IPD
,
4V6X
,
6QZP
,
8IPY
,
8GLP
,
5AJ0
,
8G6J
,
5LKS
,
6OLZ
,
8IFE
,
8G5Y
,
8G61
,
8FLF
,
6ZMI
,
8Y0W
,
7BHP
,
8INF
,
8JDK
,
8JDM
,
6OLG
,
6Z6M
,
8G5Z
,
6LSR
,
6Z6L
,
6LSS
,
7XNY
,
8FLD
,
8INK
,
8FLB
,
8FLC
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O00560 SDCBP
3
SDCBP [cytosol]
(R-HSA-373639)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [extracellular region]
(R-HSA-6806206)
0.696
5
UniProt:P63244 RACK1
1
GNB2L1 [cytosol]
(R-HSA-5626956)
0.638
3
UniProt:Q96CW1 AP2M1
6
AP2M1 [plasma membrane]
(R-HSA-167585)
AP2M1 [lysosomal membrane]
(R-HSA-196144)
AP2M1 [cytosol]
(R-HSA-182227)
AP2M1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130423)
AP2M1 [endolysosome membrane]
(R-HSA-6784828)
p-T156 AP2M1 [cytosol]
(R-HSA-8856805)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:P60953 CDC42
3
CDC42 [cytosol]
(R-HSA-442630)
CDC42 [plasma membrane]
(R-HSA-449545)
CDC42 [endoplasmic reticulum membrane]
(R-HSA-5672086)
0.547
2
UniProt:P06748 NPM1
11
NPM1 [cytosol]
(R-HSA-3008211)
p-S4-NPM1 [cytosol]
(R-HSA-6801679)
NPM1 [nucleoplasm]
(R-HSA-606320)
NPM1 [granular component]
(R-HSA-9017702)
NPM1(1-117)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699834)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699861)
NPM1(1-117)-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730697)
NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730703)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm]
(R-HSA-9725010)
polySUMO2,3-K263-NPM1 [nucleoplasm]
(R-HSA-4086056)
monoSUMO1-K263-NPM1 [nucleoplasm]
(R-HSA-4086039)
0.527
2
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-8S-N [cytosol]
(R-COV-9729335)
p-S188,206-N [cytosol]
(R-COV-9729324)
N [cytosol]
(R-COV-9694300)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
0.527
2
UniProt:O95429 BAG4
3
BAG4 [cytosol]
(R-HSA-5212670)
BAG4(1-126)-p-8Y-FGFR1(208-822) fusion [plasma membrane]
(R-HSA-8853156)
BAG4(1-126)-FGFR1(208-822) fusion [plasma membrane]
(R-HSA-8853157)
0.488
2
UniProt:P03372 ESR1
10
ESR1 [cytosol]
(R-HSA-9020968)
ESR1 [nucleoplasm]
(R-HSA-446168)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
0.462
2
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