Reactome | RPL4 [cytosol]

RPL4 [cytosol]

Stable Identifier

R-HSA-72474

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

60S ribosomal protein L4, L1

Locations in the PathwayBrowser

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Cellular responses to external stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
    - EIF2AK4 (GCN2) binds tRNA (Homo sapiens)
      - EIF2AK4:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)
      - tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)
    - EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)
      - tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)
      - tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)
    - IMPACT binds GCN1 (Homo sapiens)
      - GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)
      - IMPACT:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)
    - p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
      - tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Signaling by ROBO receptors (Homo sapiens)
      - Regulation of expression of SLITs and ROBOs (Homo sapiens)
        
        Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)
        
        Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)
        
        Translation of ROBO3.2 mRNA is negatively regulated by NMD (Homo sapiens)
        
        Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)
- rRNA processing (Homo sapiens)
  - rRNA processing in the nucleus and cytosol (Homo sapiens)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P36578 RPL4

Gene Names

RPL4, RPL1

Chain

initiator methionine:1, chain:2-427

Reference Genes

BioGPS Gene:6124 RPL4

COSMIC (genes):RPL4 RPL4

CTD Gene:6124 RPL4

dbSNP Gene:6124 RPL4

ENSEMBL:ENSG00000174444 RPL4

HGNC:10353 RPL4

KEGG Gene (Homo sapiens):6124 RPL4

Monarch:6124 RPL4

NCBI Gene:6124 RPL4

OMIM:180479 RPL4

UCSC:P36578 RPL4

Reference Transcript

RefSeq:NM_000968.3 RPL4

Other Identifiers

0002340463

0003940619

11756140_s_at

16810954

18671445

18671446

18671447

18671448

18671449

18671450

18671452

18671453

18671455

18671456

18671458

18671460

18671461

200089_PM_s_at

200089_s_at

201154_x_at

211710_x_at

2708792

2708793

2708795

2708796

2708797

2708800

2708801

2708802

2708804

3198241

33485_at

3630171

3630172

3630173

3630177

3630179

3630181

3630182

3630183

3630184

3630185

3630187

3630188

3630191

3630194

3630195

3630198

3630204

3630206

3630208

3630209

6124

7892536

7892640

7893305

7893386

7893559

7893904

7894051

7896084

7896168

7896397

7896554

80081_at

8180297

A_23_P69431

D23660_at

GE61383

GO:0000184

GO:0003674

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005730

GO:0005737

GO:0005783

GO:0005791

GO:0005829

GO:0005840

GO:0005925

GO:0006412

GO:0006413

GO:0006605

GO:0006614

GO:0006810

GO:0008150

GO:0009056

GO:0009058

GO:0015031

GO:0016020

GO:0019083

GO:0022625

GO:0032991

GO:0034641

GO:0034655

GO:0043226

GO:0044403

GO:0070062

GO:1990904

Hs.286.4.A1_3p_s_at

ILMN_1752285

PH_hs_0029384

PH_hs_0032060

TC15001579.hg

TC15002586.hg

Participant Of

hasComponent

Inferred To

Rpl4 [cytosol] (Mus musculus)

Rpl4 [cytosol] (Rattus norvegicus)

rpl-4 [cytosol] (Caenorhabditis elegans)

RPL4B [cytosol] (Saccharomyces cerevisiae)

LOC100856765 [cytosol] (Canis familiaris)

rpl401 [cytosol] (Schizosaccharomyces pombe)

RPL4A [cytosol] (Saccharomyces cerevisiae)

RpL4 [cytosol] (Drosophila melanogaster)

Ghost homologue of RPL4 [cytosol] (Xenopus tropicalis)

RPL4 [cytosol] (Bos taurus)

RPL4 [cytosol] (Gallus gallus)

RPL4 [cytosol] (Plasmodium falciparum)

RPL4 [cytosol] (Sus scrofa)

rpl402 [cytosol] (Schizosaccharomyces pombe)

Homologues of RPL4 [cytosol] (Saccharomyces cerevisiae)

Homologues of RPL4 [cytosol] (Schizosaccharomyces pombe)

rpl4 [cytosol] (Danio rerio)

rpl4 [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_000959.2

Target Pathogen

5b354852be737e166372e7c0

OpenTargets

ENSG00000174444

GeneCards

P36578

HPA

ENSG00000174444-RPL4

Ensembl

ENSG00000174444, ENSP00000311430, ENST00000307961

PRO

P36578

PDB

6Y6X, 6IP8, 4V6X, 6OLI, 5A8L, 6QZP, 5LKS, 6OLG, 6IP6, 6Y0G, 6OM0, 4UG0, 6OLZ, 5T2C, 5AJ0, 6OM7, 6Y2L, 6OLF, 6IP5, 6OLE, 6EK0, 6Y57

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.675	14
UniProt:Q99558 MAP3K14	5	MAP3K14 [cytosol] (R-HSA-168189) Active NIK [cytosol] (R-HSA-5607646) p-MAP3K14 [cytosol] (R-HSA-168187) K48polyUb-NIK [cytosol] (R-HSA-5668525) p-T559-MAP3K14 [cytosol] (R-HSA-5668531)	0.564	3
UniProt:P62753 RPS6	3	p-5S-RPS6 [cytosol] (R-HSA-165727) RPS6 [nucleoplasm] (R-HSA-6790606) RPS6 [cytosol] (R-HSA-72381)	0.527	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P03372 ESR1	8	SUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2

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