Reactome | EIF2S2 [cytosol]

EIF2S2 [cytosol]

Stable Identifier

R-HSA-72512

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

eIF2-beta, eIF-2-beta, eukaryotic translation initiation factor 2 beta subunit, eukaryotic translation initiation factor 2, subunit 2, Eukaryotic translation initiation factor 2 subunit 2, Eukaryotic translation initiation factor 2 beta subunit

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External Reference Information

External Reference

UniProt:P20042 EIF2S2

Gene Names

EIF2S2, EIF2B

Chain

initiator methionine:, chain:2-333

Reference Genes

BioGPS Gene:8894 EIF2S2

COSMIC (genes):EIF2S2 EIF2S2

CTD Gene:8894 EIF2S2

dbSNP Gene:8894 EIF2S2

ENSEMBL:ENSG00000125977 EIF2S2

ENSEMBL_homo_sapiens_GENE:ENSG00000125977.7 EIF2S2

HGNC:3266 EIF2S2

KEGG Gene (Homo sapiens):8894 EIF2S2

Monarch:8894 EIF2S2

NCBI Gene:8894 EIF2S2

OMIM:603908 EIF2S2

Reference Transcript

RefSeq:NM_003908.4 EIF2S2

Other Identifiers

11723916_at

11723917_s_at

16918485

208725_PM_at

208725_at

208726_PM_s_at

208726_s_at

2514932

2514933

2514934

2514937

2708752

3300441

3903289

3903290

3903291

3903292

3903294

3903298

3903300

3903302

3903303

3903310

3903314

3903315

3903321

39368_at

8065730

8894

A_24_P48791

A_32_P157965

GE57907

GE61655

GO:0001701

GO:0001731

GO:0001732

GO:0002176

GO:0002181

GO:0003723

GO:0003729

GO:0003743

GO:0005515

GO:0005737

GO:0005829

GO:0005850

GO:0006412

GO:0006413

GO:0008135

GO:0008584

GO:0022414

GO:0031369

GO:0045182

GO:0045202

GO:0046872

GO:0048856

GO:0065003

HMNXSV003024987

Hs.12163.0.A2_3p_at

ILMN_1798014

M29536_at

PH_hs_0030152

TC20000779.hg

g12653382_3p_a_at

Participates

as a component of

Inferred To

EIF2B [cytosol] (Gallus gallus)

Eif2s2 [cytosol] (Mus musculus)

Eif2s2 [cytosol] (Rattus norvegicus)

EIF2S2 [cytosol] (Bos taurus)

EIF2S2 [cytosol] (Canis familiaris)

EIF2S2 [cytosol] (Plasmodium falciparum)

EIF2S2 [cytosol] (Sus scrofa)

eif-2beta [cytosol] (Caenorhabditis elegans)

SUI3 [cytosol] (Saccharomyces cerevisiae)

wu:fu10f07 [cytosol] (Danio rerio)

eif2s2 [cytosol] (Dictyostelium discoideum)

eif2s2 [cytosol] (Xenopus tropicalis)

eIF2beta [cytosol] (Drosophila melanogaster)

tif212 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_003899.2

OpenTargets

ENSG00000125977

HPA

ENSG00000125977-EIF2S2

GeneCards

P20042

Ensembl

ENSG00000125977, ENSP00000364119, ENST00000374980

PRO

P20042

Pharos - Targets

P20042

Orphanet

24503

HMDB Protein

HMDBP08449

PDB

6ZMW, 7D43, 7A09, 6ZP4, 6K72, 6YBV, 6K71, 7QP6

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.666	4
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	12
UniProt:P01138 NGF	7	NGF(19-241) [extracellular region] (R-HSA-187033) NGF [Golgi lumen] (R-HSA-166515) NGF [cytosol] (R-HSA-190059) NGF(1-241) [endoplasmic reticulum lumen] (R-HSA-187026) NGF(19-241) [Golgi lumen] (R-HSA-187036) NGF(19-241) [endoplasmic reticulum lumen] (R-HSA-187047) NGF [extracellular region] (R-HSA-167034)	0.556	3
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	6
UniProt:Q92673 SORL1	2	SORL1 [endosome membrane] (R-HSA-8871475) SORL1 [Golgi membrane] (R-HSA-8871510)	0.556	3
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.556	3
UniProt:P19404 NDUFV2	1	NDUFV2 [mitochondrial inner membrane] (R-HSA-163939)	0.556	3
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	6