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EIF2B5 [cytosol]
Stable Identifier
R-HSA-72523
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
eIF2B-epsilon, translation initiation factor 2B epsilon subunit , eIF-2B GDP-GTP exchange factor, epsilon subunit, Translation initiation factor eIF-2B epsilon subunit, eIF-2B GDP-GTP exchange factor
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
Recycling of eIF2:GDP (Homo sapiens)
Formation of eIF2:GDP:eIF2B intermediate (Homo sapiens)
eIF2:GDP: eIF2B [cytosol] (Homo sapiens)
eIF2B subunits complex [cytosol] (Homo sapiens)
EIF2B5 [cytosol] (Homo sapiens)
eIF2B subunits complex [cytosol] (Homo sapiens)
EIF2B5 [cytosol] (Homo sapiens)
eIF2 activation (Homo sapiens)
eIF2:GDP: eIF2B [cytosol] (Homo sapiens)
eIF2B subunits complex [cytosol] (Homo sapiens)
EIF2B5 [cytosol] (Homo sapiens)
eIF2B subunits complex [cytosol] (Homo sapiens)
EIF2B5 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13144 EIF2B5
Gene Names
EIF2B5, EIF2BE
Chain
initiator methionine:, chain:2-721
Reference Genes
BioGPS Gene:8893 EIF2B5
COSMIC (genes):EIF2B5 EIF2B5
CTD Gene:8893 EIF2B5
dbSNP Gene:8893 EIF2B5
ENSEMBL:ENSG00000145191 EIF2B5
HGNC:3261 EIF2B5
KEGG:hsa:8893 EIF2B5
Monarch:8893 EIF2B5
NCBI Gene:8893 EIF2B5
OMIM:603945 EIF2B5
UCSC:Q13144 EIF2B5
Reference Transcript
RefSeq:NM_003907.2 EIF2B5
Other Identifiers
11744175_a_at
1558050_at
16948675
212351_PM_at
212351_at
2655388
2655389
2655390
2655391
2655392
2655396
2655397
2655398
2655399
2655400
2655401
2655402
2655403
2655404
2655405
2655406
2655407
2655408
2655409
2655410
2655411
2655412
2655413
2655414
2655415
2655417
2655418
2655419
2655420
2655421
2655422
2655423
2655424
2655425
2655426
2655427
2655428
2655429
2655431
34758_at
80651_at
8084303
81013_at
8893
A_14_P100292
A_14_P119620
A_23_P110062
GE59016
GO:0001541
GO:0002183
GO:0002376
GO:0003743
GO:0005085
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0005851
GO:0006412
GO:0006413
GO:0009408
GO:0009749
GO:0014002
GO:0014003
GO:0021766
GO:0030154
GO:0031369
GO:0034976
GO:0042552
GO:0043065
GO:0043226
GO:0043434
GO:0045182
GO:0045727
GO:0045948
GO:0048708
GO:0048856
GO:0050852
GO:0098772
HMNXSV003046956
Hs.2437.0.S1_3p_at
Hs.2437.0.S1_3p_x_at
Hs2.350779.1.S1_3p_at
Hs2.350779.1.S1_3p_x_at
ILMN_1688534
PH_hs_0023464
TC03000992.hg
U23028_at
Participates
as a component of
eIF2B subunits complex [cytosol] (Homo sapiens)
Inferred To
GCD6 [cytosol]
(Saccharomyces cerevisiae)
eIF2Bepsilon [cytosol]
(Drosophila melanogaster)
eif-2bepsilon [cytosol]
(Caenorhabditis elegans)
Eif2b5 [cytosol]
(Mus musculus)
Eif2b5 [cytosol]
(Rattus norvegicus)
tif225 [cytosol]
(Schizosaccharomyces pombe)
eif2b5 [cytosol]
(Danio rerio)
eif2b5 [cytosol]
(Dictyostelium discoideum)
eif2b5 [cytosol]
(Xenopus tropicalis)
EIF2B5 [cytosol]
(Bos taurus)
EIF2B5 [cytosol]
(Canis familiaris)
EIF2B5 [cytosol]
(Gallus gallus)
EIF2B5 [cytosol]
(Plasmodium falciparum)
EIF2B5 [cytosol]
(Sus scrofa)
Cross References
OpenTargets
ENSG00000145191
ENSEMBL
ENSP00000497160
,
ENSG00000145191
,
ENST00000648915
HPA
ENSG00000145191-EIF2B5
GeneCards
EIF2B5
PRO
Q13144
Pharos - Targets
Q13144
Orphanet
EIF2B5
GlyGen
Q13144
PDB
7VLK
,
7RLO
,
6O85
,
7KMF
,
7F64
,
7TRJ
,
3JUI
,
6K71
,
7D44
,
7F66
,
6CAJ
,
8TQZ
,
7D46
,
7D43
,
6O9Z
,
8TQO
,
7L7G
,
7L70
,
6O81
,
7D45
,
6EZO
,
7F67
,
6K72
HMDB Protein
HMDBP08377
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P32249 GPR183
1
GPR183 [plasma membrane]
(R-HSA-8851676)
0.527
4
UniProt:P21709 EPHA1
2
p-Y599,Y605-EPHA1 [plasma membrane]
(R-HSA-3928336)
EPHA1 [plasma membrane]
(R-HSA-211415)
0.527
2
UniProt:P43115 PTGER3
1
PTGER3 [plasma membrane]
(R-HSA-391828)
0.527
2
UniProt:P21579 SYT1
7
SYT1 [clathrin-sculpted monoamine transport vesicle membrane]
(R-HSA-372508)
SYT1 [plasma membrane]
(R-HSA-168786)
SYT1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-917741)
SYT1 [clathrin-sculpted glutamate transport vesicle membrane]
(R-HSA-372514)
SYT1 [clathrin-sculpted acetylcholine transport vesicle membrane]
(R-HSA-210536)
SYT1 [synaptic vesicle membrane]
(R-HSA-194789)
SYT1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869113)
0.527
3
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