Reactome | EIF2B3 [cytosol]

EIF2B3 [cytosol]

Stable Identifier

R-HSA-72525

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

eIF2B-gamma, translation initiation factor 2B gamma subunit , eIF-2B GDP-GTP exchange factor, gamma subunit, Translation initiation factor eIF-2B gamma subunit, eIF-2B GDP-GTP exchange factor

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9NR50 EIF2B3

Gene Names

EIF2B3

Chain

chain:1-452

Reference Genes

BioGPS Gene:8891 EIF2B3

COSMIC (genes):EIF2B3 EIF2B3

CTD Gene:8891 EIF2B3

dbSNP Gene:8891 EIF2B3

ENSEMBL:ENSG00000070785 EIF2B3

HGNC:3259 EIF2B3

KEGG:hsa:8891 EIF2B3

Monarch:8891 EIF2B3

NCBI Gene:8891 EIF2B3

OMIM:606273 EIF2B3

UCSC:Q9NR50 EIF2B3

Reference Transcript

Other Identifiers

11722040_a_at

16686324

218488_PM_at

218488_at

2409905

2409906

2409907

2409908

2409913

2409914

2409915

2409916

2409917

2409920

2409922

2409925

2409926

2409927

2409930

2409931

2409932

2409933

2409934

2409938

2409939

2409941

3215253

54927_at

54929_g_at

64934_at

7915640

8891

A_33_P3296372

A_33_P3305482

GE62183

GO:0002183

GO:0002376

GO:0003743

GO:0005085

GO:0005515

GO:0005737

GO:0005829

GO:0005851

GO:0006412

GO:0006413

GO:0008135

GO:0009058

GO:0009408

GO:0009749

GO:0014003

GO:0032045

GO:0043434

GO:0045182

GO:0048856

GO:0050852

GO:0098772

HMNXSV003026433

HMNXSV003056744

PH_hs_0014654

TC01002603.hg

g9966778_3p_at

Participates

as a component of

eIF2B subunits complex [cytosol] (Homo sapiens)

Inferred To

eIF2Bgamma [cytosol] (Drosophila melanogaster)

tif223 [cytosol] (Schizosaccharomyces pombe)

GCD1 [cytosol] (Saccharomyces cerevisiae)

Ghost homologue of EIF2B3 [cytosol] (Plasmodium falciparum)

Ghost homologue of EIF2B3 [cytosol] (Xenopus tropicalis)

eif2b3 [cytosol] (Danio rerio)

eif2b3 [cytosol] (Dictyostelium discoideum)

Eif2b3 [cytosol] (Mus musculus)

Eif2b3 [cytosol] (Rattus norvegicus)

eif-2Bgamma [cytosol] (Caenorhabditis elegans)

EIF2B3 [cytosol] (Bos taurus)

EIF2B3 [cytosol] (Canis familiaris)

EIF2B3 [cytosol] (Gallus gallus)

EIF2B3 [cytosol] (Sus scrofa)

Cross References

OpenTargets

ENSG00000070785

ENSEMBL

ENST00000360403, ENSP00000353575, ENST00000620860, ENSP00000361257, ENSG00000070785, ENSP00000483996, ENST00000372183

HPA

ENSG00000070785-EIF2B3

GeneCards

EIF2B3

PRO

Q9NR50

Pharos - Targets

Q9NR50

Orphanet

EIF2B3

GlyGen

Q9NR50

HMDB Protein

HMDBP08378

PDB

7VLK, 7RLO, 6O85, 7KMF, 7TRJ, 7F64, 6K71, 7D44, 7F66, 6CAJ, 8TQZ, 7D43, 7D46, 8TQO, 6O9Z, 7L7G, 7L70, 6O81, 7D45, 6EZO, 6K72, 7F67

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P32249 GPR183	1	GPR183 [plasma membrane] (R-HSA-8851676)	0.527	4
UniProt:P21709 EPHA1	2	p-Y599,Y605-EPHA1 [plasma membrane] (R-HSA-3928336) EPHA1 [plasma membrane] (R-HSA-211415)	0.527	2
UniProt:P16150 SPN	1	SPN [plasma membrane] (R-HSA-204438)	0.527	2
UniProt:P43115 PTGER3	1	PTGER3 [plasma membrane] (R-HSA-391828)	0.527	2
UniProt:P21579 SYT1	7	SYT1 [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-372508) SYT1 [plasma membrane] (R-HSA-168786) SYT1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-917741) SYT1 [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-372514) SYT1 [clathrin-sculpted acetylcholine transport vesicle membrane] (R-HSA-210536) SYT1 [synaptic vesicle membrane] (R-HSA-194789) SYT1 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869113)	0.527	2

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