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EIF3J [cytosol]
Stable Identifier
R-HSA-72534
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
eIF3-alpha, eIF-3 alpha, eIF3j, eIF3 p35, eukaryotic translation initiation factor 3 subunit 1, Eukaryotic translation initiation factor 3 subunit 1
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Homo sapiens)
Translation initiation complex formation (Homo sapiens)
Formation of translation initiation complexes containing mRNA that does not circularize (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3J [cytosol] (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3J [cytosol] (Homo sapiens)
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3J [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3J [cytosol] (Homo sapiens)
Formation of a pool of free 40S subunits (Homo sapiens)
eIF3 and eIF1A bind to the 40S subunit (Homo sapiens)
40S:eIF3:eIF1A [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3J [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3J [cytosol] (Homo sapiens)
Formation of the ternary complex, and subsequently, the 43S complex (Homo sapiens)
Formation of the 43S pre-initiation complex (Homo sapiens)
40S:eIF3:eIF1A [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3J [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3J [cytosol] (Homo sapiens)
GTP hydrolysis and joining of the 60S ribosomal subunit (Homo sapiens)
eIF2:GTP is hydrolyzed, eIFs are released (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3J [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3J [cytosol] (Homo sapiens)
Ribosomal scanning and start codon recognition (Homo sapiens)
Ribosomal scanning (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3J [cytosol] (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3J [cytosol] (Homo sapiens)
Start codon recognition (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3J [cytosol] (Homo sapiens)
L13a-mediated translational silencing of Ceruloplasmin expression (Homo sapiens)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3J [cytosol] (Homo sapiens)
phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3J [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75822 EIF3J
Gene Names
EIF3J, EIF3S1, PRO0391
Chain
initiator methionine:, chain:2-258
Reference Genes
BioGPS Gene:8669 EIF3J
COSMIC (genes):EIF3J EIF3J
CTD Gene:8669 EIF3J
dbSNP Gene:8669 EIF3J
ENSEMBL:ENSG00000104131 EIF3J
ENSEMBL_homo_sapiens_GENE:ENSG00000104131.13 EIF3J
HGNC:3270 EIF3J
KEGG Gene (Homo sapiens):8669 EIF3J
Monarch:8669 EIF3J
NCBI Gene:8669 EIF3J
OMIM:603910 EIF3J
UCSC:O75822 EIF3J
Reference Transcript
RefSeq:NM_001284336.1 EIF3J
RefSeq:NM_001284335.1 EIF3J
RefSeq:NM_003758.3 EIF3J
Other Identifiers
11725637_a_at
11725638_a_at
16800431
17123206
208264_PM_s_at
208264_s_at
208985_PM_s_at
208985_s_at
238829_PM_at
238829_at
3591964
3591965
3591966
3591970
3591971
3591973
3591976
3591977
3591979
3591981
3591982
3591983
3591984
3591985
3591986
3591987
3591988
3591989
3591990
3591991
40616_at
60448_at
7983350
8669
A_14_P106139
A_14_P139320
A_14_P200391
A_23_P54297
A_33_P3369631
GE513070
GE55981
GO:0001732
GO:0002181
GO:0002183
GO:0003743
GO:0005515
GO:0005737
GO:0005829
GO:0005852
GO:0006412
GO:0006413
GO:0016282
GO:0033290
GO:0042802
GO:0045182
GO:0065003
HMNXSV003011969
Hs.173020.0.A1_3p_at
Hs.247782.0.S1_3p_s_at
ILMN_1815345
PH_hs_0010431
TC15000340.hg
g12803762_3p_a_at
g4503510_3p_a_at
Participates
as a component of
eIF3 subunits complex [cytosol] (Homo sapiens)
Inferred To
Eif3j [cytosol]
(Rattus norvegicus)
EIF3J [cytosol]
(Bos taurus)
EIF3J [cytosol]
(Canis familiaris)
EIF3J [cytosol]
(Gallus gallus)
EIF3J [cytosol]
(Schizosaccharomyces pombe)
EIF3J [cytosol]
(Sus scrofa)
Ghost homologue of EIF3J [cytosol]
(Plasmodium falciparum)
HCR1 [cytosol]
(Saccharomyces cerevisiae)
eIF3j [cytosol]
(Drosophila melanogaster)
eif3ja [cytosol]
(Danio rerio)
eif-3.j [cytosol]
(Caenorhabditis elegans)
Eif3j1 [cytosol]
(Mus musculus)
eif3J [cytosol]
(Dictyostelium discoideum)
eif3j [cytosol]
(Xenopus tropicalis)
Homologues of EIF3J [cytosol]
(Mus musculus)
Eif3j2 [cytosol]
(Mus musculus)
Cross References
RefSeq
NP_001271264.1
,
NP_001271265.1
,
NP_003749.2
OpenTargets
ENSG00000104131
GeneCards
O75822
HPA
ENSG00000104131-EIF3J
Ensembl
ENSP00000261868
,
ENSP00000440221
,
ENST00000424492
,
ENST00000535391
,
ENSG00000104131
,
ENST00000261868
,
ENSP00000414548
PRO
O75822
Pharos - Targets
O75822
PDB
3BPJ
,
2KRB
,
6YBW
,
6ZVJ
,
6ZMW
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61221 ABCE1
2
ABCE1 [cytosol]
(R-HSA-8985209)
ABCE1 [mitochondrial matrix]
(R-HSA-5216010)
0.666
4
UniProt:Q16236 NFE2L2
13
p-S,T,S558-NFE2L2 [nucleoplasm]
(R-HSA-9795736)
p-S40, S344, S347- NFE2L2 [nucleoplasm]
(R-HSA-9762050)
p-S344, S347,T-NFE2L2 [nucleoplasm]
(R-HSA-9762048)
ub-p-S40, S335, S338- NFE2L2 [nucleoplasm]
(R-HSA-9762058)
ub-p-S335, S338,T-NFE2L2 [nucleoplasm]
(R-HSA-9762055)
ub-NFE2L2 [cytosol]
(R-HSA-9758077)
p-S40-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760018)
p-S,T-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760033)
NFE2L2 [cytosol]
(R-HSA-201566)
p-S,T-NFE2L2 [cytosol]
(R-HSA-8932311)
p-S40-NFE2L2 [cytosol]
(R-HSA-8932290)
p-S,T-NFE2L2 [nucleoplasm]
(R-HSA-9715110)
p-S40-NFE2L2 [nucleoplasm]
(R-HSA-9715109)
0.625
5
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.527
6
UniProt:P02675 FGB
5
FGB(31-491) [platelet alpha granule lumen]
(R-HSA-140921)
FGB(31-491) [extracellular region]
(R-HSA-140846)
FGB [plasma membrane]
(R-HSA-140917)
FGB(31-44) [extracellular region]
(R-HSA-140876)
FGB [extracellular region]
(R-HSA-140584)
0.527
2
UniProt:P04798 CYP1A1
1
CYP1A1 [endoplasmic reticulum membrane]
(R-HSA-52623)
0.527
2
UniProt:Q04637 EIF4G1
2
p-S1108,S1148,S1192-EIF4G1 [cytosol]
(R-HSA-165762)
EIF4G1 [cytosol]
(R-HSA-72584)
0.524
2
UniProt:P62280 RPS11
2
RPS11 [nucleoplasm]
(R-HSA-6791212)
RPS11 [cytosol]
(R-HSA-72327)
0.483
2
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