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EIF3F [cytosol]
Stable Identifier
R-HSA-72540
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
eIF3-epsilon, eIF-3 epsilon, eIF3f, eIF3 p47, eukaryotic translation initiation factor 3 subunit 5, Eukaryotic translation initiation factor 3 subunit 5, eIF3 p47 subunit
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Homo sapiens)
Translation initiation complex formation (Homo sapiens)
Formation of translation initiation complexes containing mRNA that does not circularize (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3F [cytosol] (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3F [cytosol] (Homo sapiens)
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3F [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3F [cytosol] (Homo sapiens)
Formation of a pool of free 40S subunits (Homo sapiens)
eIF3 and eIF1A bind to the 40S subunit (Homo sapiens)
40S:eIF3:eIF1A [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3F [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3F [cytosol] (Homo sapiens)
Formation of the ternary complex, and subsequently, the 43S complex (Homo sapiens)
Formation of the 43S pre-initiation complex (Homo sapiens)
40S:eIF3:eIF1A [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3F [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3F [cytosol] (Homo sapiens)
GTP hydrolysis and joining of the 60S ribosomal subunit (Homo sapiens)
eIF2:GTP is hydrolyzed, eIFs are released (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3F [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3F [cytosol] (Homo sapiens)
Ribosomal scanning and start codon recognition (Homo sapiens)
Ribosomal scanning (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3F [cytosol] (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3F [cytosol] (Homo sapiens)
Start codon recognition (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3F [cytosol] (Homo sapiens)
L13a-mediated translational silencing of Ceruloplasmin expression (Homo sapiens)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3F [cytosol] (Homo sapiens)
phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3F [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00303 EIF3F
Gene Names
EIF3F, EIF3S5
Chain
initiator methionine:, chain:2-357
Reference Genes
BioGPS Gene:8665 EIF3F
COSMIC (genes):EIF3F EIF3F
CTD Gene:8665 EIF3F
dbSNP Gene:8665 EIF3F
ENSEMBL:ENSG00000175390 EIF3F
HGNC:3275 EIF3F
KEGG:hsa:8665 EIF3F
Monarch:8665 EIF3F
NCBI Gene:8665 EIF3F
OMIM:603914 EIF3F
UCSC:O00303 EIF3F
Reference Transcript
RefSeq:NM_003754.2 EIF3F
Other Identifiers
11743101_a_at
11757296_s_at
11759437_at
11759438_x_at
16654271
16654273
16654275
16654277
16654279
16654281
16654283
16654285
16654287
16654289
16654291
16654293
16654295
16721659
18670782
18670783
18670784
18670785
18670786
18670787
18670788
18670789
18670790
18670791
18670792
18670793
18670794
18670795
18670796
18670797
18670798
18670799
18670800
18670801
200023_PM_s_at
200023_s_at
200865_3p_at
200865_PM_at
200865_at
230479_PM_at
230479_at
2483547
2483548
2483551
2483552
2483553
2483554
32576_at
3319289
3319290
3319292
3319293
3319294
3319295
3319296
3319297
3319298
3319299
3319300
3319301
3319302
3319303
3319304
3319305
3319306
3319307
3319308
3319309
3319310
3319311
3319312
3319313
3319314
3319315
3319317
3319319
3319321
3319323
3319325
3319327
3319329
3319331
3319333
3319335
3319337
3319339
3319341
3319343
3319345
3319347
3319349
3319351
3925014
4038539
4038542
49991_at
7892628
7892637
7892706
7892741
7892776
7893299
7893307
7893496
7893618
7893979
7894180
7894469
7894739
7894769
7894943
7895018
7895045
7895389
7895623
7895626
7895655
7895897
7896082
7896091
7896392
7896478
7896544
7896602
7938263
8180410
82376_r_at
8665
A_14_P102297
A_23_P142776
A_24_P395042
A_24_P940944
A_32_P196918
GE81318
GO:0001732
GO:0002183
GO:0003743
GO:0003824
GO:0004843
GO:0005515
GO:0005737
GO:0005829
GO:0005852
GO:0006412
GO:0006413
GO:0006508
GO:0008233
GO:0008234
GO:0008237
GO:0016020
GO:0016282
GO:0016787
GO:0031369
GO:0033290
GO:0042802
GO:0045182
GO:0045202
GO:0065003
GO:0071541
GO:0075522
GO:0140096
GO:0140492
HMNXSV003044922
Hs.107052.0.A1_3p_at
Hs.7811.0.S1_3p_a_at
ILMN_1694398
ILMN_1826447
PH_hs_0021683
PH_hs_0035878
PH_hs_0039525
TC11000154.hg
U94855_at
g4503518_3p_at
g4503518_3p_s_at
Participates
as a component of
eIF3 subunits complex [cytosol] (Homo sapiens)
Inferred To
EIF3F [cytosol]
(Bos taurus)
EIF3F [cytosol]
(Canis familiaris)
EIF3F [cytosol]
(Gallus gallus)
EIF3F [cytosol]
(Plasmodium falciparum)
EIF3F [cytosol]
(Sus scrofa)
Eif3f [cytosol]
(Mus musculus)
Eif3f [cytosol]
(Rattus norvegicus)
eIF3f1 [cytosol]
(Drosophila melanogaster)
eif3f [cytosol]
(Dictyostelium discoideum)
eif3f [cytosol]
(Schizosaccharomyces pombe)
eif-3.F [cytosol]
(Caenorhabditis elegans)
Ghost homologue of EIF3F [cytosol]
(Danio rerio)
Ghost homologue of EIF3F [cytosol]
(Saccharomyces cerevisiae)
Ghost homologue of EIF3F [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_003745.1
OpenTargets
ENSG00000175390
ENSEMBL
ENSP00000431800
,
ENSP00000499218
,
ENST00000651655
,
ENST00000533626
HPA
ENSG00000175390-EIF3F
PRO
O00303
Pharos - Targets
O00303
GlyGen
O00303
PDB
7QP6
,
7QP7
,
6ZON
,
6ZP4
,
6YBD
,
6ZMW
,
7A09
,
8OZ0
,
8XXN
,
6ZVJ
,
8PPL
,
3J8C
,
3J8B
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P59594 S
12
nascent Spike [endoplasmic reticulum lumen]
(R-COV-9682868)
N-glycan Spike [endoplasmic reticulum lumen]
(R-COV-9683594)
trimmed unfolded N-glycan Spike [endoplasmic reticulum lumen]
(R-COV-9683716)
trimmed N-glycan Spike [endoplasmic reticulum lumen]
(R-COV-9683608)
trimmed N-glycan-PALM-Spike [endoplasmic reticulum lumen]
(R-COV-9683638)
trimmed N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9683657)
complex N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9683617)
complex N-glycan-PALM-Spike [virion membrane]
(R-COV-9685469)
complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane]
(R-COV-9686730)
complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane]
(R-COV-9686693)
complex N-glycan-PALM-Spike S1 Fragment [virion membrane]
(R-COV-9686706)
complex N-glycan-PALM-Spike S2 Fragment [virion membrane]
(R-COV-9686724)
0.645
5
UniProt:Q969P5 FBXO32
1
FBXO32 [cytosol]
(R-HSA-264453)
0.602
7
UniProt:O15457 MSH4
1
MSH4 [nucleoplasm]
(R-HSA-912455)
0.581
6
UniProt:Q53GS7 GLE1
1
GLE1 [nucleoplasm]
(R-HSA-8932905)
0.573
2
UniProt:O14964 HGS
2
HGS [cytosol]
(R-HSA-182954)
HGS [phagocytic vesicle lumen]
(R-HSA-9635660)
0.556
3
UniProt:Q969H8 C19orf10
1
C19orf10 [endoplasmic reticulum lumen]
(R-HSA-535584)
0.556
3
UniProt:P99999 CYCS
6
CYCS [cytosol]
(R-HSA-53259)
CYCS [mitochondrial intermembrane space]
(R-HSA-114244)
Cytochrome c (oxidised) [mitochondrial inner membrane]
(R-HSA-352607)
Cytochrome c (reduced) [mitochondrial inner membrane]
(R-HSA-352609)
apo-CYCS [mitochondrial inner membrane]
(R-HSA-352608)
AcK-CYCS [mitochondrial intermembrane space]
(R-HSA-5688308)
0.556
3
UniProt:P04792 HSBP1
3
HSPB1 [cytosol]
(R-HSA-450563)
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.556
3
UniProt:O43464 HTRA2
1
HTRA2 [mitochondrial intermembrane space]
(R-HSA-56655)
0.556
3
UniProt:Q16512 PKN1
3
p-T774-PKN1 [cytosol]
(R-HSA-5623651)
PKN1 [cytosol]
(R-HSA-5623613)
p-T774-PKN1 [nucleoplasm]
(R-HSA-5625721)
0.556
3
UniProt:Q9Y5J6 TIMM10B
1
4xHC-TIMM10B [mitochondrial inner membrane]
(R-HSA-1252043)
0.556
3
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:P08123 COL1A2
20
GlcGalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen]
(R-HSA-2023602)
3x4Hyp-3Hyp-GalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen]
(R-HSA-2023558)
GalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen]
(R-HSA-2023547)
3x4Hyp-GlcGalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen]
(R-HSA-2023674)
3x4Hyp-GalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen]
(R-HSA-2023580)
3x4Hyp-3Hyp-GlcGalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen]
(R-HSA-2023663)
3x4Hyp-COL1A2(25-1366) [endoplasmic reticulum lumen]
(R-HSA-2022070)
3x4Hyp-3Hyp-COL1A2(25-1366) [endoplasmic reticulum lumen]
(R-HSA-2022501)
3x4Hyp-5Hyl-COL1A2(25-1366) [endoplasmic reticulum lumen]
(R-HSA-2022977)
3x4Hyp-3Hyp-5Hyl-COL1A2(25-1366) [endoplasmic reticulum lumen]
(R-HSA-2022966)
5Hyl-COL1A2(25-1366) [endoplasmic reticulum lumen]
(R-HSA-2022455)
Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-2(I) chain [extracellular region]
(R-HSA-2396490)
Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-2(I) chain [extracellular region]
(R-HSA-2396080)
Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-2(I) chain [extracellular region]
(R-HSA-2396375)
Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-2(I) chain [extracellular region]
(R-HSA-2396493)
Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-2(I) chain [extracellular region]
(R-HSA-2396241)
Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-2(I) chain [extracellular region]
(R-HSA-2396064)
Dehydrolysinonorlysyl 4-Hyp 5-Hyl collagen alpha-2(I) chain [extracellular region]
(R-HSA-2396361)
Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-2(I) chain [extracellular region]
(R-HSA-2396431)
Dehydrolysinonorlysyl 4-Hyp Glu-Gal-Hyl collagen alpha-2(I) chain [extracellular region]
(R-HSA-2396174)
0.556
3
UniProt:P55212 CASP6
5
CASP6(194-293) [cytosol]
(R-HSA-266128)
CASP6(24-179) [cytosol]
(R-HSA-350313)
CASP6(24-179) [nucleoplasm]
(R-HSA-352247)
CASP6(194-293) [nucleoplasm]
(R-HSA-352246)
CASP6 (1-293) [cytosol]
(R-HSA-6798132)
0.556
3
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
10
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