Reactome | EIF3H [cytosol]

EIF3H [cytosol]

Stable Identifier

R-HSA-72544

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

eIF3-gamma, eIF-3 gamma, eIF3h, eIF3 p40, eukaryotic translation initiation factor 3 subunit 3, Eukaryotic translation initiation factor 3 subunit 3, eIF3 p40 subunit

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O15372 EIF3H

Gene Names

EIF3H, EIF3S3

Chain

chain:1-352

Reference Genes

BioGPS Gene:8667 EIF3H

COSMIC (genes):EIF3H EIF3H

CTD Gene:8667 EIF3H

dbSNP Gene:8667 EIF3H

ENSEMBL:ENSG00000147677 EIF3H

HGNC:3273 EIF3H

KEGG:hsa:8667 EIF3H

Monarch:8667 EIF3H

NCBI Gene:8667 EIF3H

OMIM:603912 EIF3H

UCSC:O15372 EIF3H

Reference Transcript

RefSeq:NM_003756.2 EIF3H

Other Identifiers

11744143_a_at

11744144_at

11746130_a_at

11760274_at

17080387

201592_PM_at

201592_at

230570_PM_at

230570_at

3149764

3149765

3149766

3149767

3149768

3149769

3149770

3149772

3149773

3149777

3149778

3149779

3149780

3149781

3149782

3149783

3149785

3149788

3149795

3149797

3149798

3149799

3149804

3149805

3149806

3149825

35327_at

63611_r_at

8152465

8667

A_23_P9061

A_24_P501698

GE565787

GE61175

GO:0001732

GO:0002183

GO:0003723

GO:0003743

GO:0003824

GO:0005515

GO:0005737

GO:0005829

GO:0005852

GO:0006412

GO:0006413

GO:0006446

GO:0008233

GO:0008237

GO:0016020

GO:0016282

GO:0016787

GO:0032435

GO:0033290

GO:0043226

GO:0045182

GO:0065003

GO:0070062

GO:0071541

GO:0140096

GO:0140492

HMNXSV003012807

Hs.23606.0.A1_3p_at

ILMN_1683660

PH_hs_0022397

g4503514_3p_at

Participates

as a component of

eIF3 subunits complex [cytosol] (Homo sapiens)

Inferred To

eif3hb [cytosol] (Danio rerio)

eif3h [cytosol] (Schizosaccharomyces pombe)

eif3h [cytosol] (Xenopus tropicalis)

EIF3H [cytosol] (Bos taurus)

EIF3H [cytosol] (Canis familiaris)

EIF3H [cytosol] (Gallus gallus)

EIF3H [cytosol] (Sus scrofa)

Eif3h [cytosol] (Mus musculus)

Eif3h [cytosol] (Rattus norvegicus)

eIF3h [cytosol] (Drosophila melanogaster)

Ghost homologue of EIF3H [cytosol] (Plasmodium falciparum)

Ghost homologue of EIF3H [cytosol] (Saccharomyces cerevisiae)

eif-3.H [cytosol] (Caenorhabditis elegans)

eif3H [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_003747.1

ENSEMBL

ENST00000521861, ENSP00000429931

OpenTargets

ENSG00000147677

HPA

ENSG00000147677-EIF3H

PRO

O15372

Pharos - Targets

O15372

GlyGen

O15372

PDB

8PPL, 8XXN, 6ZVJ, 6YBD, 8OZ0, 6ZMW, 7A09, 3J8C, 7QP6, 6ZP4, 7QP7, 6ZON, 3J8B

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.556	6
UniProt:O00232 PSMD12	5	PSMD12 [cytosol] (R-HSA-68792) PSMD12 [nucleoplasm] (R-HSA-174339) PSMD12 [secretory granule lumen] (R-HSA-6800934) PSMD12 [extracellular region] (R-HSA-6806480) PSMD12 [ficolin-1-rich granule lumen] (R-HSA-6800416)	0.527	2
UniProt:P06730 EIF4E	1	EIF4E [cytosol] (R-HSA-72578)	0.527	2
UniProt:P61221 ABCE1	2	ABCE1 [cytosol] (R-HSA-8985209) ABCE1 [mitochondrial matrix] (R-HSA-5216010)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	11