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EIF3K [cytosol]
Stable Identifier
R-HSA-72554
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
eIF3k, eIF-3 p25, eukaryotic translation initiation factor 3 subunit 11, Muscle specific gene M9 protein, PTD001, HSPC029, ARG134, Eukaryotic translation initiation factor 3 subunit 11
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Homo sapiens)
Translation initiation complex formation (Homo sapiens)
Formation of translation initiation complexes containing mRNA that does not circularize (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3K [cytosol] (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3K [cytosol] (Homo sapiens)
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3K [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3K [cytosol] (Homo sapiens)
Formation of a pool of free 40S subunits (Homo sapiens)
eIF3 and eIF1A bind to the 40S subunit (Homo sapiens)
40S:eIF3:eIF1A [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3K [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3K [cytosol] (Homo sapiens)
Formation of the ternary complex, and subsequently, the 43S complex (Homo sapiens)
Formation of the 43S pre-initiation complex (Homo sapiens)
40S:eIF3:eIF1A [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3K [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3K [cytosol] (Homo sapiens)
GTP hydrolysis and joining of the 60S ribosomal subunit (Homo sapiens)
eIF2:GTP is hydrolyzed, eIFs are released (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3K [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3K [cytosol] (Homo sapiens)
Ribosomal scanning and start codon recognition (Homo sapiens)
Ribosomal scanning (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3K [cytosol] (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3K [cytosol] (Homo sapiens)
Start codon recognition (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3K [cytosol] (Homo sapiens)
L13a-mediated translational silencing of Ceruloplasmin expression (Homo sapiens)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3K [cytosol] (Homo sapiens)
phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3K [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UBQ5 EIF3K
Gene Names
EIF3K, EIF3S12, ARG134, HSPC029, MSTP001, PTD001
Chain
initiator methionine:, chain:2-218
Reference Genes
BioGPS Gene:27335 EIF3K
COSMIC (genes):EIF3K EIF3K
CTD Gene:27335 EIF3K
dbSNP Gene:27335 EIF3K
ENSEMBL:ENSG00000178982 EIF3K
HGNC:24656 EIF3K
KEGG:hsa:27335 EIF3K
Monarch:27335 EIF3K
NCBI Gene:27335 EIF3K
OMIM:609596 EIF3K
UCSC:Q9UBQ5 EIF3K
Reference Transcript
RefSeq:NM_013234.3 EIF3K
Other Identifiers
11729669_a_at
11757265_x_at
11757613_x_at
11760412_a_at
11762569_at
16861841
210501_PM_x_at
210501_x_at
212716_PM_s_at
212716_s_at
221071_3p_at
221071_PM_at
221071_at
221494_3p_x_at
221494_PM_x_at
221494_x_at
27335
31492_at
3832617
3832618
3832619
3832620
3832621
3832622
3832624
3832625
3832626
3832627
3832629
3832630
3832631
3832632
3832633
3832634
3832635
3832636
3832638
3832639
3832641
3832642
79432_at
8028514
A_14_P105683
A_23_P16394
A_23_P90264
A_24_P330971
GE53512
GE82614
GO:0001732
GO:0002183
GO:0003723
GO:0003743
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0005852
GO:0006412
GO:0006413
GO:0006446
GO:0016020
GO:0016282
GO:0032991
GO:0033290
GO:0043022
GO:0043226
GO:0045182
GO:0065003
HMNXSV003028651
Hs.324925.2.A1_3p_s_at
ILMN_1694057
PH_hs_0022575
TC19000531.hg
g11067366_3p_x_at
g5114050_3p_at
g5114050_3p_s_at
Participates
as a component of
eIF3 subunits complex [cytosol] (Homo sapiens)
Inferred To
EIF3K [cytosol]
(Bos taurus)
EIF3K [cytosol]
(Canis familiaris)
EIF3K [cytosol]
(Gallus gallus)
EIF3K [cytosol]
(Plasmodium falciparum)
EIF3K [cytosol]
(Sus scrofa)
Eif3k [cytosol]
(Mus musculus)
Eif3k [cytosol]
(Rattus norvegicus)
eif3k [cytosol]
(Danio rerio)
eif3k [cytosol]
(Xenopus tropicalis)
eIF3k [cytosol]
(Drosophila melanogaster)
eif-3.K [cytosol]
(Caenorhabditis elegans)
Ghost homologue of EIF3K [cytosol]
(Saccharomyces cerevisiae)
Ghost homologue of EIF3K [cytosol]
(Schizosaccharomyces pombe)
eif3K [cytosol]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_037366.1
ENSEMBL
ENSP00000438145
,
ENSP00000489379
,
ENST00000545173
,
ENST00000635417
,
ENST00000248342
,
ENST00000635567
,
ENSP00000248342
,
ENSP00000489438
OpenTargets
ENSG00000178982
HPA
ENSG00000178982-EIF3K
PRO
Q9UBQ5
Pharos - Targets
Q9UBQ5
GlyGen
Q9UBQ5
PDB
6YBD
,
8OZ0
,
6ZMW
,
6FEC
,
7A09
,
8PPL
,
3J8C
,
8XXN
,
6ZVJ
,
3J8B
,
1RZ4
,
6ZP4
,
7QP6
,
6ZON
,
7QP7
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P30281 CCND3
2
CCND3 [nucleoplasm]
(R-HSA-113835)
CCND3 [cytosol]
(R-HSA-68333)
0.691
4
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.615
11
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