Reactome | EIF4G1 [cytosol]

EIF4G1 [cytosol]

Stable Identifier

R-HSA-72584

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

eIF4G, eIF-4-gamma, eIF-4G, eukaryotic translation initiation factor 4 gamma, P220, Eukaryotic translation initiation factor 4 gamma, p220

Icon

Locations in the PathwayBrowser for interactor UniProt:O00571 DDX3X

Expand all

External Reference Information

External Reference

UniProt:Q04637 EIF4G1

Gene Names

EIF4G1, EIF4F, EIF4G, EIF4GI

Chain

initiator methionine:, chain:1-1599

Reference Genes

BioGPS Gene:1981 EIF4G1

COSMIC (genes):EIF4G1 EIF4G1

CTD Gene:1981 EIF4G1

dbSNP Gene:1981 EIF4G1

ENSEMBL:ENSG00000114867 EIF4G1

HGNC:3296 EIF4G1

KEGG:hsa:1981 EIF4G1

Monarch:1981 EIF4G1

NCBI Gene:1981 EIF4G1

OMIM:600495 EIF4G1

UCSC:Q04637 EIF4G1

Reference Transcript

Participates

as a component of

as an input of

as an output of

as a member of

EIF4G [cytosol] (Homo sapiens)

Other forms of this molecule

p-S1108,S1148,S1192-EIF4G1 [cytosol]

Inferred To

TIF4631 [cytosol] (Saccharomyces cerevisiae)

Eif4g1 [cytosol] (Mus musculus)

Eif4g1 [cytosol] (Rattus norvegicus)

eIF4G1 [cytosol] (Drosophila melanogaster)

Homologues of EIF4G1 [cytosol] (Drosophila melanogaster)

Homologues of EIF4G1 [cytosol] (Plasmodium falciparum)

Ghost homologue of EIF4G1 [cytosol] (Danio rerio)

ifg-1 [cytosol] (Caenorhabditis elegans)

eif4g1 [cytosol] (Xenopus tropicalis)

tif471 [cytosol] (Schizosaccharomyces pombe)

eIF4G2 [cytosol] (Drosophila melanogaster)

eif4g [cytosol] (Dictyostelium discoideum)

EIF4G1 [cytosol] (Bos taurus)

EIF4G1 [cytosol] (Canis familiaris)

EIF4G1 [cytosol] (Gallus gallus)

EIF4G1 [cytosol] (Plasmodium falciparum)

EIF4G1 [cytosol] (Sus scrofa)

Cross References

OpenTargets

ENSG00000114867

ENSEMBL

ENSP00000343450, ENSP00000411826, ENST00000342981, ENSP00000416255, ENST00000424196, ENSP00000376320, ENST00000352767, ENSP00000338020, ENST00000392537, ENSG00000114867, ENSP00000317600, ENSP00000316879, ENST00000382330, ENST00000434061, ENST00000350481, ENST00000346169, ENSP00000371767, ENSP00000391935, ENST00000414031

GeneCards

EIF4G1

HPA

ENSG00000114867-EIF4G1

PRO

Q04637

Pharos - Targets

Q04637

GlyGen

Q04637

Orphanet

EIF4G1

PDB

8OZ0, 1LJ2, 5T46, 6ZMW, 2W97, 1UG3, 5EHC, 5ZK5, 8HUJ, 5EIR, 4F02, 8J7R, 4AZA, 5EI3

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P60842 EIF4A1	1	EIF4A1 [cytosol] (R-HSA-72573)	0.964	17
UniProt:P06730 EIF4E	1	EIF4E [cytosol] (R-HSA-72578)	0.924	13
UniProt:P11940 PABPC1	1	PABPC1 [cytosol] (R-HSA-156803)	0.835	6
UniProt:Q14240 EIF4A2	1	EIF4A2 [cytosol] (R-HSA-72575)	0.656	4
UniProt:Q9BWF3-1 RBM4			0.591	4
UniProt:Q9UGR2 Z3H7B			0.567	3
UniProt:P23116	1	Eif3a [cytosol] (R-MMU-72546)	0.564	2
UniProt:P55884 EIF3B	1	EIF3B [cytosol] (R-HSA-72542)	0.564	2
UniProt:Q9BUB5 MKNK1	1	p-T250,T255,T385,S437-MKNK1 [cytosol] (R-HSA-947860)	0.564	3
UniProt:O00571 DDX3X	3	DDX3X [ficolin-1-rich granule lumen] (R-HSA-6801273) DDX3X [extracellular region] (R-HSA-6806507) DDX3X [secretory granule lumen] (R-HSA-6801275)	0.557	3
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.528	3
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	4
UniProt:Q13112 CAF1B			0.527	2
UniProt:Q06787 FMR1			0.527	2
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.527	3
UniProt:O75822 EIF3J	1	EIF3J [cytosol] (R-HSA-72534)	0.524	2
UniProt:Q14103-4 HNRNPD	2	HNRNPD-4 [cytosol] (R-HSA-450442) Ub-HNRNPD-4 [cytosol] (R-HSA-451232)	0.499	3
UniProt:Q9J0X9 Q9J0X9			0.499	3
UniProt:Q13283 G3BP1	1	G3BP1 [cytosol] (R-HSA-9729517)	0.491	2
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.483	2
UniProt:P51116 FXR2			0.483	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	7
UniProt:P62280 RPS11	2	RPS11 [cytosol] (R-HSA-72327) RPS11 [nucleoplasm] (R-HSA-6791212)	0.483	2
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.483	2
UniProt:Q00721 NSP3			0.482	2
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.462	2

Cite Us!