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EIF4B [cytosol]
Stable Identifier
R-HSA-72589
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
eIF4B, eIF-4B, eukaryotic translation initiation factor 4B, Eukaryotic translation initiation factor 4B
Icon
Locations in the PathwayBrowser for interactor UniProt:Q9BSI4 TINF2
Expand all
Metabolism of RNA (Homo sapiens)
Deadenylation-dependent mRNA decay (Homo sapiens)
Deadenylation of mRNA (Homo sapiens)
CCR4-NOT complex deadenylates mRNA (Homo sapiens)
EIF4B [cytosol] (Homo sapiens)
PARN deadenylates mRNA (Homo sapiens)
EIF4B [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Homo sapiens)
Cap-bound mRNA is activated by helicases (Homo sapiens)
EIF4B [cytosol] (Homo sapiens)
GTP hydrolysis and joining of the 60S ribosomal subunit (Homo sapiens)
eIF2:GTP is hydrolyzed, eIFs are released (Homo sapiens)
EIF4B [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MTOR signalling (Homo sapiens)
mTORC1-mediated signalling (Homo sapiens)
Phosphorylation and activation of eIF4B by activated S6K1 (Homo sapiens)
EIF4B [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P23588 EIF4B
Gene Names
EIF4B
Chain
chain:1-611
Reference Genes
BioGPS Gene:1975 EIF4B
COSMIC (genes):EIF4B EIF4B
CTD Gene:1975 EIF4B
dbSNP Gene:1975 EIF4B
ENSEMBL:ENSG00000063046 EIF4B
HGNC:3285 EIF4B
KEGG:hsa:1975 EIF4B
Monarch:1975 EIF4B
NCBI Gene:1975 EIF4B
OMIM:603928 EIF4B
UCSC:P23588 EIF4B
Reference Transcript
RefSeq:NM_001417.6 EIF4B
RefSeq:NM_001330654.1 EIF4B
Other Identifiers
11747066_x_at
11752470_s_at
11752757_s_at
11752758_x_at
11756144_s_at
16751570
1975
211937_PM_at
211937_at
211938_PM_at
211938_at
2639039
2660283
2999321
3017474
3017478
3017482
3017483
3017484
3017486
3017487
3017488
3017489
3017491
3017492
3017493
3017494
3017495
3017496
3180872
3180876
3180877
3180878
3180879
3415618
3415622
3415625
3415626
3415627
3415629
3415630
3415631
3415632
3415633
3415634
3415637
3415639
3415640
3415641
3415642
3415643
3415644
3415645
3415646
3415647
3415648
3415649
3415650
3415651
3415652
3415653
3415654
3415655
3415657
3415658
3415659
3415660
3415661
3415662
39110_at
4018280
4018281
4018282
4018283
4018285
4018286
4018288
4018289
4018291
4018292
4018293
4018294
4018295
4018298
7955646
8135268
87803_s_at
A_23_P162679
A_24_P218970
GE81018
GE84662
GE85788
GO:0003676
GO:0003723
GO:0003743
GO:0005515
GO:0005829
GO:0006412
GO:0006413
GO:0006446
GO:0016281
GO:0045182
HMNXSV003014771
Hs.283330.1.S1_3p_s_at
Hs.93379.0.S1_3p_at
ILMN_1655497
PH_hs_0031414
TC12000425.hg
X55733_at
Participates
as a component of
deadenylated mRNP regulated by BTG4 [cytosol] (Homo sapiens)
mRNP regulated by BTG4 [cytosol] (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
Uridylated partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
Partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
Translatable mRNA Complex [cytosol] (Homo sapiens)
as an output of
eIF2:GTP is hydrolyzed, eIFs are released (Homo sapiens)
PARN deadenylates mRNA (Homo sapiens)
CCR4-NOT complex deadenylates mRNA (Homo sapiens)
as an input of
Cap-bound mRNA is activated by helicases (Homo sapiens)
Phosphorylation and activation of eIF4B by activated S6K1 (Homo sapiens)
Other forms of this molecule
p-S422-EIF4B [cytosol]
Inferred To
NOP13 [cytosol]
(Saccharomyces cerevisiae)
eif4b [cytosol]
(Xenopus tropicalis)
Ghost homologue of EIF4B [cytosol]
(Caenorhabditis elegans)
Ghost homologue of EIF4B [cytosol]
(Danio rerio)
Ghost homologue of EIF4B [cytosol]
(Dictyostelium discoideum)
Ghost homologue of EIF4B [cytosol]
(Drosophila melanogaster)
Ghost homologue of EIF4B [cytosol]
(Rattus norvegicus)
Homologues of EIF4B [cytosol]
(Saccharomyces cerevisiae)
EIF4B [cytosol]
(Bos taurus)
EIF4B [cytosol]
(Canis familiaris)
EIF4B [cytosol]
(Gallus gallus)
EIF4B [cytosol]
(Plasmodium falciparum)
EIF4B [cytosol]
(Sus scrofa)
Eif4b [cytosol]
(Mus musculus)
sce3 [cytosol]
(Schizosaccharomyces pombe)
TIF3 [cytosol]
(Saccharomyces cerevisiae)
Cross References
RefSeq
NP_001408.2
,
NP_001317583.1
ENSEMBL
ENST00000262056
,
ENST00000416762
,
ENSP00000262056
,
ENSP00000412530
OpenTargets
ENSG00000063046
HPA
ENSG00000063046-EIF4B
PRO
P23588
Pharos - Targets
P23588
GlyGen
P23588
PDB
6FEC
,
1WI8
,
2J76
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14152 EIF3A
1
EIF3A [cytosol]
(R-HSA-72546)
0.667
3
UniProt:Q86V38 Q86V38
0.556
3
UniProt:P02489 CRYAA
0.556
3
UniProt:Q92876 KLK6
0.556
3
UniProt:Q9BSI4 TINF2
1
TINF2 [nucleoplasm]
(R-HSA-174883)
0.508
2
IntAct:EBI-1108795 NPM
0.499
2
UniProt:P53350 PLK1
4
PLK1 [cytosol]
(R-HSA-164603)
p-T210-PLK1 [nucleoplasm]
(R-HSA-3002800)
p-T210-PLK1 [cytosol]
(R-HSA-3000318)
PLK1 [nucleoplasm]
(R-HSA-156720)
0.489
3
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.483
2
UniProt:O75821 EIF3G
1
EIF3G [cytosol]
(R-HSA-72538)
0.483
2
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