Ribosomal scanning

Stable Identifier
R-HSA-72621
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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The mRNA-bound ribosomal complex moves along the 5'-untranslated region (5'-UTR) of the mRNA from its initial site to the initiation codon to form a 48S complex, in which the initiation codon (AUG) is base paired to the anticodon of the Met-tRNAi. It is not known whether eIF4A (or another ATPase, such as DED1) facilitates scanning by melting mRNA secondary structures or by actively propelling the ribosome.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
translation initiation factor activity of eIF1 [cytosol]
Physical Entity
Activity
This event is regulated
Orthologous Events
Created