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Formation of eIF2:GDP:eIF2B intermediate
Stable Identifier
R-HSA-72670
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
Recycling of eIF2:GDP (Homo sapiens)
Formation of eIF2:GDP:eIF2B intermediate (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Inactive eIF2:GDP binds eIF2B to form an eIF2:GDP:eIF2B intermediate.
Literature References
PubMed ID
Title
Journal
Year
2491852
Mechanism of the nucleotide exchange reaction in eukaryotic polypeptide chain initiation. Characterization of the guanine nucleotide exchange factor as a GTP-binding protein.
Dholakia, JN
,
Wahba, AJ
J Biol Chem
1989
3356695
The catalytic mechanism of guanine nucleotide exchange factor action and competitive inhibition by phosphorylated eukaryotic initiation factor 2.
Henshaw, EC
,
Rowlands, AG
,
Panniers, R
J Biol Chem
1988
Participants
Input
eIF2:GDP [cytosol]
(Homo sapiens)
eIF2B subunits complex [cytosol]
(Homo sapiens)
Output
eIF2:GDP: eIF2B [cytosol]
(Homo sapiens)
Participates
as an event of
Recycling of eIF2:GDP (Homo sapiens)
Orthologous Events
Formation of eIF2:GDP:eIF2B intermediate (Bos taurus)
Formation of eIF2:GDP:eIF2B intermediate (Caenorhabditis elegans)
Formation of eIF2:GDP:eIF2B intermediate (Canis familiaris)
Formation of eIF2:GDP:eIF2B intermediate (Danio rerio)
Formation of eIF2:GDP:eIF2B intermediate (Dictyostelium discoideum)
Formation of eIF2:GDP:eIF2B intermediate (Drosophila melanogaster)
Formation of eIF2:GDP:eIF2B intermediate (Gallus gallus)
Formation of eIF2:GDP:eIF2B intermediate (Mus musculus)
Formation of eIF2:GDP:eIF2B intermediate (Plasmodium falciparum)
Formation of eIF2:GDP:eIF2B intermediate (Rattus norvegicus)
Formation of eIF2:GDP:eIF2B intermediate (Saccharomyces cerevisiae)
Formation of eIF2:GDP:eIF2B intermediate (Schizosaccharomyces pombe)
Formation of eIF2:GDP:eIF2B intermediate (Sus scrofa)
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