eIF5B:GTP is hydrolyzed and released

Stable Identifier
Reaction [dissociation]
Homo sapiens
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Once the 60S subunit joins the translation initiation complex, eIF5B hydrolyzes its GTP and is released from the now 80S monosome. The fully assembled 80s ribosome is now ready to start elongation of the polypeptide chain.

Literature References
PubMed ID Title Journal Year
10659855 The joining of ribosomal subunits in eukaryotes requires eIF5B.

Pestova, TV, Lomakin, IB, Lee, JH, Choi, SK, Dever, TE, Hellen, CU

Nature 2000
1095581 Purification and characterization of homogeneous initiation factor M2A from rabbit reticulocytes.

Merrick, WC, Kemper, WM, Anderson, WF

J Biol Chem 1975
Participant Of
Orthologous Events
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