Formation of the ternary complex, and subsequently, the 43S complex

Stable Identifier
R-HSA-72695
Type
Pathway
Species
Homo sapiens
Compartment
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Binding of the methionyl-tRNA initiator to the active eIF2:GTP complex results in the formation of the ternary complex. Subsequently, this Met-tRNAi:eIF2:GTP (ternary) complex binds to the complex formed by the 40S subunit, eIF3 and eIF1A, to form the 43S complex.

Literature References
PubMed ID Title Journal Year
641056 The mechanism of action of protein synthesis initiation factors from rabbit reticulocytes.

Benne, R, Hershey, JW

J Biol Chem 1978
592399 Initiation of mammalian protein synthesis. II. The assembly of the initiation complex with purified initiation factors.

Trachsel, H, Erni, B, Schreier, MH, Staehelin, T

J Mol Biol 1978
1104615 Binding of MET-TRNAf and GTP to homogeneous initiation factor MP.

Safer, B, Adams, SL, Anderson, WF, Merrick, WC

J Biol Chem 1976
  Post-Transcriptional Control of Gene Expression

McCarthy, JE, Tuite, M

  1990
429297 Binding and release of radiolabeled eukaryotic initiation factors 2 and 3 during 80 S initiation complex formation.

Peterson, DT, Merrick, WC, Safer, B

J Biol Chem 1979
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