Start codon recognition

Stable Identifier
R-HSA-72697
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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Start codon recognition
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The AUG initiation codon in the mRNA is recognized by base pairing with the anticodon of the Met-tRNAi. This reaction requires eIF1, eIF1A, eIF2 and eIF5.

Literature References
PubMed ID Title Journal Year
9732867 Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons.

Pestova, TV, Borukhov, SI, Hellen, CU

Nature 1999
  Translational Control of Gene Expression

Sonenberg, N, Hershey, JW, Mathews, MB

  2001
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
translation initiation factor activity of eIF1 [cytosol]
Physical Entity
eIF1 [cytosol]
Activity
translation initiation factor activity (0003743)
Orthologous Events
Start codon recognition (Caenorhabditis elegans)
Start codon recognition (Canis familiaris)
Start codon recognition (Dictyostelium discoideum)
Start codon recognition (Drosophila melanogaster)
Start codon recognition (Mus musculus)
Start codon recognition (Plasmodium falciparum)
Start codon recognition (Rattus norvegicus)
Start codon recognition (Saccharomyces cerevisiae)
Start codon recognition (Schizosaccharomyces pombe)
Cross References
Target Pathogen
Created
Merrick, WC  (2002-12-16)
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