Start codon recognition

Stable Identifier
R-HSA-72697
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The AUG initiation codon in the mRNA is recognized by base pairing with the anticodon of the Met-tRNAi. This reaction requires eIF1, eIF1A, eIF2 and eIF5.

Literature References
PubMed ID Title Journal Year
9732867 Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons.

Pestova, TV, Borukhov, SI, Hellen, CU

Nature 1999
  Translational Control of Gene Expression

Sonenberg, N, Hershey, JW, Mathews, MB

  2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
translation initiation factor activity of eIF1 [cytosol]
Physical Entity
Activity
Orthologous Events
Created
Cite Us!