Ribosomal scanning and start codon recognition

Stable Identifier
R-HSA-72702
Type
Pathway
Species
Homo sapiens
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The 80S ribosome bound to the mRNA moves along the mRNA molecule from its initial site to the initiation codon and forms a 48S complex, in which the initiation codon is base paired to the anticodon of the Met-tRNAi. Proper recognition of the AUG initiation codon depends on base pairing with the anticodon of the Met-tRNAi and requires eIF1, eIF1A, eIF2 and eIF5.

Literature References
PubMed ID Title Journal Year
641056 The mechanism of action of protein synthesis initiation factors from rabbit reticulocytes.

Benne, R, Hershey, JW

J Biol Chem 1978
592399 Initiation of mammalian protein synthesis. II. The assembly of the initiation complex with purified initiation factors.

Trachsel, H, Erni, B, Schreier, MH, Staehelin, T

J Mol Biol 1978
  Translational Control of Gene Expression

Sonenberg, N, Hershey, JW, Mathews, MB

  2001
7000367 Evaluation of the "scanning model" for initiation of protein synthesis in eucaryotes.

Kozak, M

Cell 1981
9732867 Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons.

Pestova, TV, Borukhov, SI, Hellen, CU

Nature 1999
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