SLC33A1 transports Ac-CoA from cytosol to Golgi lumen

Stable Identifier
R-HSA-727759
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The human gene SLC33A1 encodes acetyl-CoA transporter AT1 (Kanamori et al. 1997). Acetyl-CoA is transported to the lumen of the Golgi apparatus, where it serves as the substrate of acetyltransferases that O-acetylates sialyl residues of gangliosides and glycoproteins. Defects in SLC33A1 are the cause of spastic paraplegia autosomal dominant type 42 (SPG42) which is a neurodegenerative disorder (Lin et al. 2008).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
acetyl-CoA transporter activity of SLC33A1 [Golgi membrane]
Physical Entity
Activity
Orthologous Events